Iron as Therapeutic Targets in Human Diseases Volume 1
Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the...
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| Format: | Online |
| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online pristup: | 44742 |
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| author | Gozzelino, Raffaella Poli, Maura Arosio, Paolo |
| author_browse | Arosio, Paolo Gozzelino, Raffaella Poli, Maura |
| author_facet | Gozzelino, Raffaella Poli, Maura Arosio, Paolo |
| author_sort | Gozzelino, Raffaella |
| collection | Directory of Open Access Books |
| description | Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions. |
| format | Online |
| id | doab-20.500.12854ir-50679 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-506792024-04-05T12:32:20Z Iron as Therapeutic Targets in Human Diseases Volume 1 Gozzelino, Raffaella Poli, Maura Arosio, Paolo QH301-705.5 QD415-436 Q1-390 developmental Anemia of chronic disease neurodegeneration supplementation MHC iron chelation therapy osteoblast serum biomarker FeSO4 haptoglobin prevention brain development pituitary trauma hepcidin Alzheimer’s disease chaotropes social behavior Africa macrophage anemia of inflammation Tfr2 chelation cardiomyocyte IV iron therapy Oxidative stress treatment chronic kidney disease iron homeostasis oxygen sensing iron chelators age-related macular degeneration (AMD) pharmaceutical targets non-transferrin-bound iron (NTBI) iron dextran pulmonary arterial hypertension labile iron low and middle income countries ferroportin gut microbiota reducibility non-HFE oxidative stress antitumor compound senescence electron transfer nanotechnology iron deficiency neonatal period heme oxygenase hypoxia Anemia NCOA4 patient blood management microbiome anemia iron mobilization iron release phlebotomy peritoneal dialysis Friedreich Ataxia ferritin CD8+ T cells M cells neurodegenerative disease NaFeEDTA vascular calcification cinnamic acid derivatives oral iron salts lipid acute lung injury Iron-sulfur Interleukin-6 neurodegeneration with brain iron accumulation macrophages erythroblastic islands cystic fibrosis neuroimmune responses flavin nucleotide hemopexin Iron chelators nutrient iron developing countries hereditary hypoferritinemia iron cancer Indonesia n/a Hfe HFE chronic heart failure iron supplementation intestinal inflammation TNF chelators hemolysis children pulmonary arterial smooth muscle cells cytokines didox intravenous iron T lymphocytes colorectal cancer infants liver ferritinophagy hereditary hyperferritinemia SCFA rheumatoid arthritis membrane interactions Sucrosomial® iron lung Kupffer cell iron chelation erythrophagocytosis acute kidney injury neurophysiology iron transporters iron absorption infection ferroptosis fluorescent iron chelator neonatal SNC immunity mycobacteria non-haem iron natural history 3-hydroxy-4-pyridinone haem inflammation bone homeostasis cardiovascular disease heme heme homeostasis protein binding brain iron deficiency anemia Fe2+-chelating activity bioengineering Mek/Erk Bmp/Smad iron delivery genetic hemochromatosis osteoclast histidine rhodamine COPD hemorrhage antibacterial activity bacteria SLC40A1 transferrin receptor drug delivery nanocage soybean seed ferritin pig iron metabolism kidney innate immunity cataracts syndrome erythropoiesis obesity mucosal immunity iron overload fluorophore binding ability inflammatory bowel disease (IBD) osteoporosis biomarker bioavailability adverse event profile metabolism iron-carbohydrate complex kinetics flavonoids iron regulatory proteins lung infection non transferrin bound iron central nurse macrophage iron processing malaria neurodegenerative diseases multifunctional iron chelators retina neuroinflammation anti-hepcidin therapy lung diseases anaemia RRM2 cognition mitochondria therapy NBIA red pulp macrophage efficacy hemochromatosis tolerability oral iron therapy growth venesections thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions. 2021-02-11T16:41:50Z 2021-02-11T16:41:50Z 2020-04-07 23:07:08 2020 book 44742 9783039280827 9783039280834 https://directory.doabooks.org/handle/20.500.12854/50679 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2016 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-083-4 10.3390/books978-3-03928-083-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039280827 9783039280834 472 open access |
| spellingShingle | QH301-705.5 QD415-436 Q1-390 developmental Anemia of chronic disease neurodegeneration supplementation MHC iron chelation therapy osteoblast serum biomarker FeSO4 haptoglobin prevention brain development pituitary trauma hepcidin Alzheimer’s disease chaotropes social behavior Africa macrophage anemia of inflammation Tfr2 chelation cardiomyocyte IV iron therapy Oxidative stress treatment chronic kidney disease iron homeostasis oxygen sensing iron chelators age-related macular degeneration (AMD) pharmaceutical targets non-transferrin-bound iron (NTBI) iron dextran pulmonary arterial hypertension labile iron low and middle income countries ferroportin gut microbiota reducibility non-HFE oxidative stress antitumor compound senescence electron transfer nanotechnology iron deficiency neonatal period heme oxygenase hypoxia Anemia NCOA4 patient blood management microbiome anemia iron mobilization iron release phlebotomy peritoneal dialysis Friedreich Ataxia ferritin CD8+ T cells M cells neurodegenerative disease NaFeEDTA vascular calcification cinnamic acid derivatives oral iron salts lipid acute lung injury Iron-sulfur Interleukin-6 neurodegeneration with brain iron accumulation macrophages erythroblastic islands cystic fibrosis neuroimmune responses flavin nucleotide hemopexin Iron chelators nutrient iron developing countries hereditary hypoferritinemia iron cancer Indonesia n/a Hfe HFE chronic heart failure iron supplementation intestinal inflammation TNF chelators hemolysis children pulmonary arterial smooth muscle cells cytokines didox intravenous iron T lymphocytes colorectal cancer infants liver ferritinophagy hereditary hyperferritinemia SCFA rheumatoid arthritis membrane interactions Sucrosomial® iron lung Kupffer cell iron chelation erythrophagocytosis acute kidney injury neurophysiology iron transporters iron absorption infection ferroptosis fluorescent iron chelator neonatal SNC immunity mycobacteria non-haem iron natural history 3-hydroxy-4-pyridinone haem inflammation bone homeostasis cardiovascular disease heme heme homeostasis protein binding brain iron deficiency anemia Fe2+-chelating activity bioengineering Mek/Erk Bmp/Smad iron delivery genetic hemochromatosis osteoclast histidine rhodamine COPD hemorrhage antibacterial activity bacteria SLC40A1 transferrin receptor drug delivery nanocage soybean seed ferritin pig iron metabolism kidney innate immunity cataracts syndrome erythropoiesis obesity mucosal immunity iron overload fluorophore binding ability inflammatory bowel disease (IBD) osteoporosis biomarker bioavailability adverse event profile metabolism iron-carbohydrate complex kinetics flavonoids iron regulatory proteins lung infection non transferrin bound iron central nurse macrophage iron processing malaria neurodegenerative diseases multifunctional iron chelators retina neuroinflammation anti-hepcidin therapy lung diseases anaemia RRM2 cognition mitochondria therapy NBIA red pulp macrophage efficacy hemochromatosis tolerability oral iron therapy growth venesections thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Gozzelino, Raffaella Poli, Maura Arosio, Paolo Iron as Therapeutic Targets in Human Diseases Volume 1 |
| title | Iron as Therapeutic Targets in Human Diseases Volume 1 |
| title_full | Iron as Therapeutic Targets in Human Diseases Volume 1 |
| title_fullStr | Iron as Therapeutic Targets in Human Diseases Volume 1 |
| title_full_unstemmed | Iron as Therapeutic Targets in Human Diseases Volume 1 |
| title_short | Iron as Therapeutic Targets in Human Diseases Volume 1 |
| title_sort | iron as therapeutic targets in human diseases volume 1 |
| topic | QH301-705.5 QD415-436 Q1-390 developmental Anemia of chronic disease neurodegeneration supplementation MHC iron chelation therapy osteoblast serum biomarker FeSO4 haptoglobin prevention brain development pituitary trauma hepcidin Alzheimer’s disease chaotropes social behavior Africa macrophage anemia of inflammation Tfr2 chelation cardiomyocyte IV iron therapy Oxidative stress treatment chronic kidney disease iron homeostasis oxygen sensing iron chelators age-related macular degeneration (AMD) pharmaceutical targets non-transferrin-bound iron (NTBI) iron dextran pulmonary arterial hypertension labile iron low and middle income countries ferroportin gut microbiota reducibility non-HFE oxidative stress antitumor compound senescence electron transfer nanotechnology iron deficiency neonatal period heme oxygenase hypoxia Anemia NCOA4 patient blood management microbiome anemia iron mobilization iron release phlebotomy peritoneal dialysis Friedreich Ataxia ferritin CD8+ T cells M cells neurodegenerative disease NaFeEDTA vascular calcification cinnamic acid derivatives oral iron salts lipid acute lung injury Iron-sulfur Interleukin-6 neurodegeneration with brain iron accumulation macrophages erythroblastic islands cystic fibrosis neuroimmune responses flavin nucleotide hemopexin Iron chelators nutrient iron developing countries hereditary hypoferritinemia iron cancer Indonesia n/a Hfe HFE chronic heart failure iron supplementation intestinal inflammation TNF chelators hemolysis children pulmonary arterial smooth muscle cells cytokines didox intravenous iron T lymphocytes colorectal cancer infants liver ferritinophagy hereditary hyperferritinemia SCFA rheumatoid arthritis membrane interactions Sucrosomial® iron lung Kupffer cell iron chelation erythrophagocytosis acute kidney injury neurophysiology iron transporters iron absorption infection ferroptosis fluorescent iron chelator neonatal SNC immunity mycobacteria non-haem iron natural history 3-hydroxy-4-pyridinone haem inflammation bone homeostasis cardiovascular disease heme heme homeostasis protein binding brain iron deficiency anemia Fe2+-chelating activity bioengineering Mek/Erk Bmp/Smad iron delivery genetic hemochromatosis osteoclast histidine rhodamine COPD hemorrhage antibacterial activity bacteria SLC40A1 transferrin receptor drug delivery nanocage soybean seed ferritin pig iron metabolism kidney innate immunity cataracts syndrome erythropoiesis obesity mucosal immunity iron overload fluorophore binding ability inflammatory bowel disease (IBD) osteoporosis biomarker bioavailability adverse event profile metabolism iron-carbohydrate complex kinetics flavonoids iron regulatory proteins lung infection non transferrin bound iron central nurse macrophage iron processing malaria neurodegenerative diseases multifunctional iron chelators retina neuroinflammation anti-hepcidin therapy lung diseases anaemia RRM2 cognition mitochondria therapy NBIA red pulp macrophage efficacy hemochromatosis tolerability oral iron therapy growth venesections thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 QD415-436 Q1-390 developmental Anemia of chronic disease neurodegeneration supplementation MHC iron chelation therapy osteoblast serum biomarker FeSO4 haptoglobin prevention brain development pituitary trauma hepcidin Alzheimer’s disease chaotropes social behavior Africa macrophage anemia of inflammation Tfr2 chelation cardiomyocyte IV iron therapy Oxidative stress treatment chronic kidney disease iron homeostasis oxygen sensing iron chelators age-related macular degeneration (AMD) pharmaceutical targets non-transferrin-bound iron (NTBI) iron dextran pulmonary arterial hypertension labile iron low and middle income countries ferroportin gut microbiota reducibility non-HFE oxidative stress antitumor compound senescence electron transfer nanotechnology iron deficiency neonatal period heme oxygenase hypoxia Anemia NCOA4 patient blood management microbiome anemia iron mobilization iron release phlebotomy peritoneal dialysis Friedreich Ataxia ferritin CD8+ T cells M cells neurodegenerative disease NaFeEDTA vascular calcification cinnamic acid derivatives oral iron salts lipid acute lung injury Iron-sulfur Interleukin-6 neurodegeneration with brain iron accumulation macrophages erythroblastic islands cystic fibrosis neuroimmune responses flavin nucleotide hemopexin Iron chelators nutrient iron developing countries hereditary hypoferritinemia iron cancer Indonesia n/a Hfe HFE chronic heart failure iron supplementation intestinal inflammation TNF chelators hemolysis children pulmonary arterial smooth muscle cells cytokines didox intravenous iron T lymphocytes colorectal cancer infants liver ferritinophagy hereditary hyperferritinemia SCFA rheumatoid arthritis membrane interactions Sucrosomial® iron lung Kupffer cell iron chelation erythrophagocytosis acute kidney injury neurophysiology iron transporters iron absorption infection ferroptosis fluorescent iron chelator neonatal SNC immunity mycobacteria non-haem iron natural history 3-hydroxy-4-pyridinone haem inflammation bone homeostasis cardiovascular disease heme heme homeostasis protein binding brain iron deficiency anemia Fe2+-chelating activity bioengineering Mek/Erk Bmp/Smad iron delivery genetic hemochromatosis osteoclast histidine rhodamine COPD hemorrhage antibacterial activity bacteria SLC40A1 transferrin receptor drug delivery nanocage soybean seed ferritin pig iron metabolism kidney innate immunity cataracts syndrome erythropoiesis obesity mucosal immunity iron overload fluorophore binding ability inflammatory bowel disease (IBD) osteoporosis biomarker bioavailability adverse event profile metabolism iron-carbohydrate complex kinetics flavonoids iron regulatory proteins lung infection non transferrin bound iron central nurse macrophage iron processing malaria neurodegenerative diseases multifunctional iron chelators retina neuroinflammation anti-hepcidin therapy lung diseases anaemia RRM2 cognition mitochondria therapy NBIA red pulp macrophage efficacy hemochromatosis tolerability oral iron therapy growth venesections thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
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