Kidney Inflammation, Injury and Regeneration
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal...
I tiakina i:
| Ngā kaituhi matua: | , , |
|---|---|
| Hōputu: | Online |
| Reo: | Ingarihi |
| I whakaputaina: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Ngā marau: | |
| Urunga tuihono: | 45991 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
|
| _version_ | 1869528888248369152 |
|---|---|
| author | Koch, Benjamin Geiger, Helmut Baer, Patrick C. |
| author_browse | Baer, Patrick C. Geiger, Helmut Koch, Benjamin |
| author_facet | Koch, Benjamin Geiger, Helmut Baer, Patrick C. |
| author_sort | Koch, Benjamin |
| collection | Directory of Open Access Books |
| description | Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets. |
| format | Online |
| id | doab-20.500.12854ir-51086 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-510862024-03-31T13:10:02Z Kidney Inflammation, Injury and Regeneration Koch, Benjamin Geiger, Helmut Baer, Patrick C. R5-920 RC31-1245 microRNAs n/a transcription ischemia/reperfusion injury DSS-colitis kidney inflammation therapeutics targets CXCL13 glomerulus interleukin-6 rhabdomyolysis IgA nephropathy CREB Regulated Transcriptional Coactivators (CRTC) slit diaphragm injury xanthine oxidase Salt Inducible Kinase (SIK) acute and chronic kidney disease therapeutic target KIT-IgA score G-protein-coupled bile acid receptor (TGR5) lysophosphatidic acid glomerular injury IL-18 mesenchymal stem cells Taiwan acute kidney injury renal ischemia-reperfusion long non-coding RNA fibrosis acute kidney failure diabetic kidney diseases chronic kidney disease lncRNA LPS-binding protein endotoxemia-induced oliguric kidney injury dapagliflozin cPLA2 and COX-2 NLRP3 inflammasome CmklR1 haem chronic kidney injury omega-3 fatty acid noninvasive inflammation regulated necrosis GLP-1 receptor agonists miRNA AKI SGLT2 inhibitors diabetic kidney disease extracellular vesicles podocin type IV collagen epithelial cells nephrin 2-kidney-1-clip renal fibrosis papilla diagnostics necrosis non-coding RNAs podocyte Thy1.1 nephritis KIT assay oxidative stress conditioned medium C-reactive protein pericyte myofibroblast Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) endotoxemia modifier gene polymorphism renal stem cells kidney polyploidization Class IIa Histone Deacetylases (HDAC) 2k1c molecular signaling proximal tubule arachidonic acid empagliflozin tubular injury signaling cascade signal transduction inflammatory maker niches biomarkers renal progenitors type V collagen cyclooxygenase focal segmental glomerulosclerosis inflammatory bowel disease (IBD) chronic kidney disease (CKD) allograft rejection renovascular hypertension genotype molecular mechanisms ROS prediction glomerular filtration barrier (GFB) alport syndrome scattered tubular cells long non-coding RNAs renal inflammation lysophosphatidic acid receptor cAMP Regulatory Element Binding Protein (CREB) Farnesiferol B differentiation mesenchymal stromal cells modified-MSCs kidney transplantation polyunsaturated fatty acids apoptosis type I collagen diabetes mellitus natural products lipoxygenase stem cell T cell-mediated rejection exosomes renal injury obese kidney fibrosis kidney injury cytotoxicity mesenchymal stem cell pigment nephropathy mesodermal stem cell ischemia-reperfusion cytochrome P450 renal cell carcinoma hematuria B-cell attracting chemokine microRNA chemerin glomerular basement membrane glomerular damage renal tubular cells kidney proximal tubule exosome hypertension diabetic nephropathy thema EDItEUR::M Medicine and Nursing Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets. 2021-02-11T17:07:19Z 2021-02-11T17:07:19Z 2020-06-09 16:38:57 2020 book 45991 9783039285389 9783039285396 https://directory.doabooks.org/handle/20.500.12854/51086 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2165 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-539-6 10.3390/books978-3-03928-539-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039285389 9783039285396 496 open access |
| spellingShingle | R5-920 RC31-1245 microRNAs n/a transcription ischemia/reperfusion injury DSS-colitis kidney inflammation therapeutics targets CXCL13 glomerulus interleukin-6 rhabdomyolysis IgA nephropathy CREB Regulated Transcriptional Coactivators (CRTC) slit diaphragm injury xanthine oxidase Salt Inducible Kinase (SIK) acute and chronic kidney disease therapeutic target KIT-IgA score G-protein-coupled bile acid receptor (TGR5) lysophosphatidic acid glomerular injury IL-18 mesenchymal stem cells Taiwan acute kidney injury renal ischemia-reperfusion long non-coding RNA fibrosis acute kidney failure diabetic kidney diseases chronic kidney disease lncRNA LPS-binding protein endotoxemia-induced oliguric kidney injury dapagliflozin cPLA2 and COX-2 NLRP3 inflammasome CmklR1 haem chronic kidney injury omega-3 fatty acid noninvasive inflammation regulated necrosis GLP-1 receptor agonists miRNA AKI SGLT2 inhibitors diabetic kidney disease extracellular vesicles podocin type IV collagen epithelial cells nephrin 2-kidney-1-clip renal fibrosis papilla diagnostics necrosis non-coding RNAs podocyte Thy1.1 nephritis KIT assay oxidative stress conditioned medium C-reactive protein pericyte myofibroblast Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) endotoxemia modifier gene polymorphism renal stem cells kidney polyploidization Class IIa Histone Deacetylases (HDAC) 2k1c molecular signaling proximal tubule arachidonic acid empagliflozin tubular injury signaling cascade signal transduction inflammatory maker niches biomarkers renal progenitors type V collagen cyclooxygenase focal segmental glomerulosclerosis inflammatory bowel disease (IBD) chronic kidney disease (CKD) allograft rejection renovascular hypertension genotype molecular mechanisms ROS prediction glomerular filtration barrier (GFB) alport syndrome scattered tubular cells long non-coding RNAs renal inflammation lysophosphatidic acid receptor cAMP Regulatory Element Binding Protein (CREB) Farnesiferol B differentiation mesenchymal stromal cells modified-MSCs kidney transplantation polyunsaturated fatty acids apoptosis type I collagen diabetes mellitus natural products lipoxygenase stem cell T cell-mediated rejection exosomes renal injury obese kidney fibrosis kidney injury cytotoxicity mesenchymal stem cell pigment nephropathy mesodermal stem cell ischemia-reperfusion cytochrome P450 renal cell carcinoma hematuria B-cell attracting chemokine microRNA chemerin glomerular basement membrane glomerular damage renal tubular cells kidney proximal tubule exosome hypertension diabetic nephropathy thema EDItEUR::M Medicine and Nursing Koch, Benjamin Geiger, Helmut Baer, Patrick C. Kidney Inflammation, Injury and Regeneration |
| title | Kidney Inflammation, Injury and Regeneration |
| title_full | Kidney Inflammation, Injury and Regeneration |
| title_fullStr | Kidney Inflammation, Injury and Regeneration |
| title_full_unstemmed | Kidney Inflammation, Injury and Regeneration |
| title_short | Kidney Inflammation, Injury and Regeneration |
| title_sort | kidney inflammation injury and regeneration |
| topic | R5-920 RC31-1245 microRNAs n/a transcription ischemia/reperfusion injury DSS-colitis kidney inflammation therapeutics targets CXCL13 glomerulus interleukin-6 rhabdomyolysis IgA nephropathy CREB Regulated Transcriptional Coactivators (CRTC) slit diaphragm injury xanthine oxidase Salt Inducible Kinase (SIK) acute and chronic kidney disease therapeutic target KIT-IgA score G-protein-coupled bile acid receptor (TGR5) lysophosphatidic acid glomerular injury IL-18 mesenchymal stem cells Taiwan acute kidney injury renal ischemia-reperfusion long non-coding RNA fibrosis acute kidney failure diabetic kidney diseases chronic kidney disease lncRNA LPS-binding protein endotoxemia-induced oliguric kidney injury dapagliflozin cPLA2 and COX-2 NLRP3 inflammasome CmklR1 haem chronic kidney injury omega-3 fatty acid noninvasive inflammation regulated necrosis GLP-1 receptor agonists miRNA AKI SGLT2 inhibitors diabetic kidney disease extracellular vesicles podocin type IV collagen epithelial cells nephrin 2-kidney-1-clip renal fibrosis papilla diagnostics necrosis non-coding RNAs podocyte Thy1.1 nephritis KIT assay oxidative stress conditioned medium C-reactive protein pericyte myofibroblast Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) endotoxemia modifier gene polymorphism renal stem cells kidney polyploidization Class IIa Histone Deacetylases (HDAC) 2k1c molecular signaling proximal tubule arachidonic acid empagliflozin tubular injury signaling cascade signal transduction inflammatory maker niches biomarkers renal progenitors type V collagen cyclooxygenase focal segmental glomerulosclerosis inflammatory bowel disease (IBD) chronic kidney disease (CKD) allograft rejection renovascular hypertension genotype molecular mechanisms ROS prediction glomerular filtration barrier (GFB) alport syndrome scattered tubular cells long non-coding RNAs renal inflammation lysophosphatidic acid receptor cAMP Regulatory Element Binding Protein (CREB) Farnesiferol B differentiation mesenchymal stromal cells modified-MSCs kidney transplantation polyunsaturated fatty acids apoptosis type I collagen diabetes mellitus natural products lipoxygenase stem cell T cell-mediated rejection exosomes renal injury obese kidney fibrosis kidney injury cytotoxicity mesenchymal stem cell pigment nephropathy mesodermal stem cell ischemia-reperfusion cytochrome P450 renal cell carcinoma hematuria B-cell attracting chemokine microRNA chemerin glomerular basement membrane glomerular damage renal tubular cells kidney proximal tubule exosome hypertension diabetic nephropathy thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC31-1245 microRNAs n/a transcription ischemia/reperfusion injury DSS-colitis kidney inflammation therapeutics targets CXCL13 glomerulus interleukin-6 rhabdomyolysis IgA nephropathy CREB Regulated Transcriptional Coactivators (CRTC) slit diaphragm injury xanthine oxidase Salt Inducible Kinase (SIK) acute and chronic kidney disease therapeutic target KIT-IgA score G-protein-coupled bile acid receptor (TGR5) lysophosphatidic acid glomerular injury IL-18 mesenchymal stem cells Taiwan acute kidney injury renal ischemia-reperfusion long non-coding RNA fibrosis acute kidney failure diabetic kidney diseases chronic kidney disease lncRNA LPS-binding protein endotoxemia-induced oliguric kidney injury dapagliflozin cPLA2 and COX-2 NLRP3 inflammasome CmklR1 haem chronic kidney injury omega-3 fatty acid noninvasive inflammation regulated necrosis GLP-1 receptor agonists miRNA AKI SGLT2 inhibitors diabetic kidney disease extracellular vesicles podocin type IV collagen epithelial cells nephrin 2-kidney-1-clip renal fibrosis papilla diagnostics necrosis non-coding RNAs podocyte Thy1.1 nephritis KIT assay oxidative stress conditioned medium C-reactive protein pericyte myofibroblast Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) endotoxemia modifier gene polymorphism renal stem cells kidney polyploidization Class IIa Histone Deacetylases (HDAC) 2k1c molecular signaling proximal tubule arachidonic acid empagliflozin tubular injury signaling cascade signal transduction inflammatory maker niches biomarkers renal progenitors type V collagen cyclooxygenase focal segmental glomerulosclerosis inflammatory bowel disease (IBD) chronic kidney disease (CKD) allograft rejection renovascular hypertension genotype molecular mechanisms ROS prediction glomerular filtration barrier (GFB) alport syndrome scattered tubular cells long non-coding RNAs renal inflammation lysophosphatidic acid receptor cAMP Regulatory Element Binding Protein (CREB) Farnesiferol B differentiation mesenchymal stromal cells modified-MSCs kidney transplantation polyunsaturated fatty acids apoptosis type I collagen diabetes mellitus natural products lipoxygenase stem cell T cell-mediated rejection exosomes renal injury obese kidney fibrosis kidney injury cytotoxicity mesenchymal stem cell pigment nephropathy mesodermal stem cell ischemia-reperfusion cytochrome P450 renal cell carcinoma hematuria B-cell attracting chemokine microRNA chemerin glomerular basement membrane glomerular damage renal tubular cells kidney proximal tubule exosome hypertension diabetic nephropathy thema EDItEUR::M Medicine and Nursing |
| url | 45991 |
| work_keys_str_mv | AT kochbenjamin kidneyinflammationinjuryandregeneration AT geigerhelmut kidneyinflammationinjuryandregeneration AT baerpatrickc kidneyinflammationinjuryandregeneration |