Lipid Signaling in T Cell Development and Function
Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in m...
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Frontiers Media SA
2021
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| גישה מקוונת: | 19579 |
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| _version_ | 1869525220491001856 |
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| author | Karsten Sauer Klaus Okkenhaug |
| author_browse | Karsten Sauer Klaus Okkenhaug |
| author_facet | Karsten Sauer Klaus Okkenhaug |
| author_sort | Karsten Sauer |
| collection | Directory of Open Access Books |
| description | Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas. |
| format | Online |
| id | doab-20.500.12854ir-51776 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-517762024-03-31T13:08:35Z Lipid Signaling in T Cell Development and Function Karsten Sauer Klaus Okkenhaug R5-920 RC581-607 eicosanoid Inositol diacylglyerol PI3K Vitamin D T cell SHIP Pten Adipokine Lipid thema EDItEUR::M Medicine and Nursing Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas. 2021-02-11T17:49:05Z 2021-02-11T17:49:05Z 2016-08-16 10:34:25 2015 book 19579 16648714 9782889196975 https://directory.doabooks.org/handle/20.500.12854/51776 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Lipid_Signaling_in_T_Cell_Development_and_Function/717 http://journal.frontiersin.org/researchtopic/1104/lipid-signaling-in-t-cell-development-and-function Frontiers Media SA 10.3389/978-2-88919-697-5 10.3389/978-2-88919-697-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196975 142 open access |
| spellingShingle | R5-920 RC581-607 eicosanoid Inositol diacylglyerol PI3K Vitamin D T cell SHIP Pten Adipokine Lipid thema EDItEUR::M Medicine and Nursing Karsten Sauer Klaus Okkenhaug Lipid Signaling in T Cell Development and Function |
| title | Lipid Signaling in T Cell Development and Function |
| title_full | Lipid Signaling in T Cell Development and Function |
| title_fullStr | Lipid Signaling in T Cell Development and Function |
| title_full_unstemmed | Lipid Signaling in T Cell Development and Function |
| title_short | Lipid Signaling in T Cell Development and Function |
| title_sort | lipid signaling in t cell development and function |
| topic | R5-920 RC581-607 eicosanoid Inositol diacylglyerol PI3K Vitamin D T cell SHIP Pten Adipokine Lipid thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 eicosanoid Inositol diacylglyerol PI3K Vitamin D T cell SHIP Pten Adipokine Lipid thema EDItEUR::M Medicine and Nursing |
| url | 19579 |
| work_keys_str_mv | AT karstensauer lipidsignalingintcelldevelopmentandfunction AT klausokkenhaug lipidsignalingintcelldevelopmentandfunction |