Lipopolysaccharides (LPSs)
The cytoplasm of Gram-negative bacteria is bound by three layers: an inner membrane, a layer of peptidoglycan, and an outer membrane. The outer membrane is an asymmetric lipidic bilayer, with phospholipids on its inner surface and lipopolysaccharides (LPSs) on the outside, with the latter being the...
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Առցանց հասանելիություն: | 44738 |
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Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1869514280189034496 |
|---|---|
| author | Tomás, Juan M. |
| author_browse | Tomás, Juan M. |
| author_facet | Tomás, Juan M. |
| author_sort | Tomás, Juan M. |
| collection | Directory of Open Access Books |
| description | The cytoplasm of Gram-negative bacteria is bound by three layers: an inner membrane, a layer of peptidoglycan, and an outer membrane. The outer membrane is an asymmetric lipidic bilayer, with phospholipids on its inner surface and lipopolysaccharides (LPSs) on the outside, with the latter being the major component of the outer leaflet and covering nearly three-quarters of the total outer cell surface. All LPSs possess the same general chemical architecture independently of bacterial activity (pathogenic, symbiotic, commensal), ecological niche (human, animal, soil, plant, water), or growth conditions. Endotoxins are large amphiphilic molecules consisting of a hydrophilic polysaccharide component and a covalently bound hydrophobic and highly conserved lipid component, termed lipid A (the endotoxin subunit). The polysaccharide component can be divided into two subdomains: the internal and conserved core region as well as the more external and highly variable O-specific chain, also referred to as the O-antigen due to its immunogenic properties. LPSs are endotoxins, one of the most potent class of activators of the mammalian immune system; they can be released from cell surfaces of bacteria during multiplication, lysis, and death. LPS can act through its biological center (lipid A component) on various cell types, of which macrophages and monocytes are the most important. |
| format | Online |
| id | doab-20.500.12854ir-51778 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-517782024-03-30T23:21:36Z Lipopolysaccharides (LPSs) Tomás, Juan M. R5-920 RC581-607 LAL and LER cornea Aeromonas tear fluid protein dynamics O-antigen Plesiomonas shigelloides lipopolysaccharide induced TNF? factor hepcidin pJNK rat Proteus penneri lipid A LPS tolerance iron regulatory protein 1 (IRP1) MALDI-TOF MS outer core oligosaccharide inhibitor design phagosome lipopolysaccharide NMR spectroscopy Bordetellae respiratory syncytial virus dendritic cell MAT GT-B polysorbate Edwardsiella tarda LPS innate immune d-galactan I inflammation aspirin lipopolysaccharide (LPS) collagen heptosyltransferase rhinovirus serum resistance hypothalamic inflammation NMR IL-6/JAK2/STAT3 pathway glycosyltransferase toll-like receptor core oligosaccharide Coxiella burnetii virenose oxidative stress ESI FT-ICR endotoxin Salmonella P65 (nuclear factor-?B) nitric oxide (NO) allergic respiratory disorder bacteria adhesion molecule ESI MSn endotoxaemia HR-MAS double-stranded RNA epithelial cell mouse lipopolysaccharide stimulation complement inner core oligosaccharide LPS aggregates Q fever O-acetylation sepsis chemokine hygiene hypothesis anti-conjugate serum structural determination Small Angle X-ray Scattering genomics mass spectrometry keratocyte insulin resistance Low Endotoxin Recovery phase transitions Megalobrama amblycephala Bordetella holmesii Erwinia amylovora structure time response fibroblast genomic sialic acid ESI MS reptile-associated salmonellosis thema EDItEUR::M Medicine and Nursing The cytoplasm of Gram-negative bacteria is bound by three layers: an inner membrane, a layer of peptidoglycan, and an outer membrane. The outer membrane is an asymmetric lipidic bilayer, with phospholipids on its inner surface and lipopolysaccharides (LPSs) on the outside, with the latter being the major component of the outer leaflet and covering nearly three-quarters of the total outer cell surface. All LPSs possess the same general chemical architecture independently of bacterial activity (pathogenic, symbiotic, commensal), ecological niche (human, animal, soil, plant, water), or growth conditions. Endotoxins are large amphiphilic molecules consisting of a hydrophilic polysaccharide component and a covalently bound hydrophobic and highly conserved lipid component, termed lipid A (the endotoxin subunit). The polysaccharide component can be divided into two subdomains: the internal and conserved core region as well as the more external and highly variable O-specific chain, also referred to as the O-antigen due to its immunogenic properties. LPSs are endotoxins, one of the most potent class of activators of the mammalian immune system; they can be released from cell surfaces of bacteria during multiplication, lysis, and death. LPS can act through its biological center (lipid A component) on various cell types, of which macrophages and monocytes are the most important. 2021-02-11T17:49:13Z 2021-02-11T17:49:13Z 2020-04-07 23:07:08 2020 book 44738 9783039282562 9783039282579 https://directory.doabooks.org/handle/20.500.12854/51778 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2012 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-257-9 10.3390/books978-3-03928-257-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039282562 9783039282579 390 open access |
| spellingShingle | R5-920 RC581-607 LAL and LER cornea Aeromonas tear fluid protein dynamics O-antigen Plesiomonas shigelloides lipopolysaccharide induced TNF? factor hepcidin pJNK rat Proteus penneri lipid A LPS tolerance iron regulatory protein 1 (IRP1) MALDI-TOF MS outer core oligosaccharide inhibitor design phagosome lipopolysaccharide NMR spectroscopy Bordetellae respiratory syncytial virus dendritic cell MAT GT-B polysorbate Edwardsiella tarda LPS innate immune d-galactan I inflammation aspirin lipopolysaccharide (LPS) collagen heptosyltransferase rhinovirus serum resistance hypothalamic inflammation NMR IL-6/JAK2/STAT3 pathway glycosyltransferase toll-like receptor core oligosaccharide Coxiella burnetii virenose oxidative stress ESI FT-ICR endotoxin Salmonella P65 (nuclear factor-?B) nitric oxide (NO) allergic respiratory disorder bacteria adhesion molecule ESI MSn endotoxaemia HR-MAS double-stranded RNA epithelial cell mouse lipopolysaccharide stimulation complement inner core oligosaccharide LPS aggregates Q fever O-acetylation sepsis chemokine hygiene hypothesis anti-conjugate serum structural determination Small Angle X-ray Scattering genomics mass spectrometry keratocyte insulin resistance Low Endotoxin Recovery phase transitions Megalobrama amblycephala Bordetella holmesii Erwinia amylovora structure time response fibroblast genomic sialic acid ESI MS reptile-associated salmonellosis thema EDItEUR::M Medicine and Nursing Tomás, Juan M. Lipopolysaccharides (LPSs) |
| title | Lipopolysaccharides (LPSs) |
| title_full | Lipopolysaccharides (LPSs) |
| title_fullStr | Lipopolysaccharides (LPSs) |
| title_full_unstemmed | Lipopolysaccharides (LPSs) |
| title_short | Lipopolysaccharides (LPSs) |
| title_sort | lipopolysaccharides lpss |
| topic | R5-920 RC581-607 LAL and LER cornea Aeromonas tear fluid protein dynamics O-antigen Plesiomonas shigelloides lipopolysaccharide induced TNF? factor hepcidin pJNK rat Proteus penneri lipid A LPS tolerance iron regulatory protein 1 (IRP1) MALDI-TOF MS outer core oligosaccharide inhibitor design phagosome lipopolysaccharide NMR spectroscopy Bordetellae respiratory syncytial virus dendritic cell MAT GT-B polysorbate Edwardsiella tarda LPS innate immune d-galactan I inflammation aspirin lipopolysaccharide (LPS) collagen heptosyltransferase rhinovirus serum resistance hypothalamic inflammation NMR IL-6/JAK2/STAT3 pathway glycosyltransferase toll-like receptor core oligosaccharide Coxiella burnetii virenose oxidative stress ESI FT-ICR endotoxin Salmonella P65 (nuclear factor-?B) nitric oxide (NO) allergic respiratory disorder bacteria adhesion molecule ESI MSn endotoxaemia HR-MAS double-stranded RNA epithelial cell mouse lipopolysaccharide stimulation complement inner core oligosaccharide LPS aggregates Q fever O-acetylation sepsis chemokine hygiene hypothesis anti-conjugate serum structural determination Small Angle X-ray Scattering genomics mass spectrometry keratocyte insulin resistance Low Endotoxin Recovery phase transitions Megalobrama amblycephala Bordetella holmesii Erwinia amylovora structure time response fibroblast genomic sialic acid ESI MS reptile-associated salmonellosis thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 LAL and LER cornea Aeromonas tear fluid protein dynamics O-antigen Plesiomonas shigelloides lipopolysaccharide induced TNF? factor hepcidin pJNK rat Proteus penneri lipid A LPS tolerance iron regulatory protein 1 (IRP1) MALDI-TOF MS outer core oligosaccharide inhibitor design phagosome lipopolysaccharide NMR spectroscopy Bordetellae respiratory syncytial virus dendritic cell MAT GT-B polysorbate Edwardsiella tarda LPS innate immune d-galactan I inflammation aspirin lipopolysaccharide (LPS) collagen heptosyltransferase rhinovirus serum resistance hypothalamic inflammation NMR IL-6/JAK2/STAT3 pathway glycosyltransferase toll-like receptor core oligosaccharide Coxiella burnetii virenose oxidative stress ESI FT-ICR endotoxin Salmonella P65 (nuclear factor-?B) nitric oxide (NO) allergic respiratory disorder bacteria adhesion molecule ESI MSn endotoxaemia HR-MAS double-stranded RNA epithelial cell mouse lipopolysaccharide stimulation complement inner core oligosaccharide LPS aggregates Q fever O-acetylation sepsis chemokine hygiene hypothesis anti-conjugate serum structural determination Small Angle X-ray Scattering genomics mass spectrometry keratocyte insulin resistance Low Endotoxin Recovery phase transitions Megalobrama amblycephala Bordetella holmesii Erwinia amylovora structure time response fibroblast genomic sialic acid ESI MS reptile-associated salmonellosis thema EDItEUR::M Medicine and Nursing |
| url | 44738 |
| work_keys_str_mv | AT tomasjuanm lipopolysaccharideslpss |