Liver Myofibroblasts
Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in dis...
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| Main Authors: | , , |
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| Formato: | Online |
| Idioma: | inglés |
| Publicado: |
Frontiers Media SA
2021
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| Subjects: | |
| Acceso en liña: | 18376 |
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| _version_ | 1869520238996881408 |
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| author | Jiri Kanta Alena Mrkvicova Ralf Weiskirchen |
| author_browse | Alena Mrkvicova Jiri Kanta Ralf Weiskirchen |
| author_facet | Jiri Kanta Alena Mrkvicova Ralf Weiskirchen |
| author_sort | Jiri Kanta |
| collection | Directory of Open Access Books |
| description | Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis. |
| format | Online |
| id | doab-20.500.12854ir-51895 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-518952024-03-31T22:45:08Z Liver Myofibroblasts Jiri Kanta Alena Mrkvicova Ralf Weiskirchen QP1-981 Q1-390 Xanthohumol Hepatic Stellate Cells therapy Portal myofibroblasts Cytoglobin miRNA Myofibroblasts Autophagy Matrix stiffness NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis. 2021-02-11T17:56:28Z 2021-02-11T17:56:28Z 2016-01-19 14:05:46 2016 book 18376 16648714 9782889199891 https://directory.doabooks.org/handle/20.500.12854/51895 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Liver_Myofibroblasts/1038#nogo http://journal.frontiersin.org/researchtopic/3177/liver-myofibroblasts Frontiers Media SA 10.3389/978-2-88919-989-1 10.3389/978-2-88919-989-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199891 99 open access |
| spellingShingle | QP1-981 Q1-390 Xanthohumol Hepatic Stellate Cells therapy Portal myofibroblasts Cytoglobin miRNA Myofibroblasts Autophagy Matrix stiffness NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Jiri Kanta Alena Mrkvicova Ralf Weiskirchen Liver Myofibroblasts |
| title | Liver Myofibroblasts |
| title_full | Liver Myofibroblasts |
| title_fullStr | Liver Myofibroblasts |
| title_full_unstemmed | Liver Myofibroblasts |
| title_short | Liver Myofibroblasts |
| title_sort | liver myofibroblasts |
| topic | QP1-981 Q1-390 Xanthohumol Hepatic Stellate Cells therapy Portal myofibroblasts Cytoglobin miRNA Myofibroblasts Autophagy Matrix stiffness NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 Xanthohumol Hepatic Stellate Cells therapy Portal myofibroblasts Cytoglobin miRNA Myofibroblasts Autophagy Matrix stiffness NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 18376 |
| work_keys_str_mv | AT jirikanta livermyofibroblasts AT alenamrkvicova livermyofibroblasts AT ralfweiskirchen livermyofibroblasts |