Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands
The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of se...
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| Main Authors: | , |
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| פורמט: | Online |
| שפה: | אנגלית |
| יצא לאור: |
Springer Nature
2021
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| נושאים: | |
| גישה מקוונת: | 24703 |
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אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
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| _version_ | 1869515427582836736 |
|---|---|
| author | Irena Roterman Leszek Konieczny |
| author_browse | Irena Roterman Leszek Konieczny |
| author_facet | Irena Roterman Leszek Konieczny |
| author_sort | Irena Roterman |
| collection | Directory of Open Access Books |
| description | The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. |
| format | Online |
| id | doab-20.500.12854ir-52013 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | ojs |
| spelling | doab-20.500.12854ir-520132024-04-05T17:30:42Z Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands Irena Roterman Leszek Konieczny QD415-436 ligands congo red amyloids immunotargeting techniques intramolecular immunological signals thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. 2021-02-11T18:04:29Z 2021-02-11T18:04:29Z 2017-11-24 17:24:09 2017 book 24703 0 9783319656397 9783319656380 https://directory.doabooks.org/handle/20.500.12854/52013 eng image/jpeg Attribution 4.0 International http://www.springer.com/de/book/9783319656380 https://link.springer.com/book/10.1007/978-3-319-65639-7 Springer Nature https://doi.org/10.1007/978-3-319-65639-7 https://doi.org/10.1007/978-3-319-65639-7 9fa3421d-f917-4153-b9ab-fc337c396b5a 9783319656397 9783319656380 136 open access |
| spellingShingle | QD415-436 ligands congo red amyloids immunotargeting techniques intramolecular immunological signals thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Irena Roterman Leszek Konieczny Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands |
| title | Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands |
| title_full | Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands |
| title_fullStr | Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands |
| title_full_unstemmed | Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands |
| title_short | Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands |
| title_sort | self assembled molecules new kind of protein ligands supramolecular ligands |
| topic | QD415-436 ligands congo red amyloids immunotargeting techniques intramolecular immunological signals thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | QD415-436 ligands congo red amyloids immunotargeting techniques intramolecular immunological signals thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | 24703 |
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