Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis
Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissue...
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| Հիմնական հեղինակներ: | , , , |
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| Ձևաչափ: | Online |
| Լեզու: | անգլերեն |
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Frontiers Media SA
2021
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| Խորագրեր: | |
| Առցանց հասանելիություն: | 25634 |
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Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1869517020442132480 |
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| author | Tarcio Teodoro Braga Niels Olsen Saraiva Camara Ana Paula Lepique Ivan C. Moura |
| author_browse | Ana Paula Lepique Ivan C. Moura Niels Olsen Saraiva Camara Tarcio Teodoro Braga |
| author_facet | Tarcio Teodoro Braga Niels Olsen Saraiva Camara Ana Paula Lepique Ivan C. Moura |
| author_sort | Tarcio Teodoro Braga |
| collection | Directory of Open Access Books |
| description | Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissues and situations and hypothesize on their role in promoting inflammation or stimulating tissue repair. Through innate immune recognition system macrophages can launch several effector artilleries that culminate in the production of various types of inflammatory mediators as cytokines, chemokines, lipid mediators and oxygen reactive species, which in turn, influence the behavior of other cells. Furthermore, macrophages and interacting cells are also susceptible to metabolic changes that ultimately will define the outcome macrophage signaling and its effect in the tissue. Here, we present a concise series of discussions on the role of macrophages, its response to the microenvironment and effects on other cells during tissue injury and repair. Triggering of inflammasome in macrophage activation and function is of special interest in this issue. We will emphasize the role of different macrophage subpopulations and the plasticity of these cells during fibrotic process in different models of diseases. |
| format | Online |
| id | doab-20.500.12854ir-52534 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-525342024-03-30T23:22:00Z Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis Tarcio Teodoro Braga Niels Olsen Saraiva Camara Ana Paula Lepique Ivan C. Moura R5-920 RC581-607 macrophage subtypes inflammation chronic diseases fibrosis thema EDItEUR::M Medicine and Nursing Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissues and situations and hypothesize on their role in promoting inflammation or stimulating tissue repair. Through innate immune recognition system macrophages can launch several effector artilleries that culminate in the production of various types of inflammatory mediators as cytokines, chemokines, lipid mediators and oxygen reactive species, which in turn, influence the behavior of other cells. Furthermore, macrophages and interacting cells are also susceptible to metabolic changes that ultimately will define the outcome macrophage signaling and its effect in the tissue. Here, we present a concise series of discussions on the role of macrophages, its response to the microenvironment and effects on other cells during tissue injury and repair. Triggering of inflammasome in macrophage activation and function is of special interest in this issue. We will emphasize the role of different macrophage subpopulations and the plasticity of these cells during fibrotic process in different models of diseases. 2021-02-11T18:31:20Z 2021-02-11T18:31:20Z 2018-02-27 16:16:45 2017 book 25634 16648714 9782889453320 https://directory.doabooks.org/handle/20.500.12854/52534 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/books/Macrophages_Role_in_Integrating_Tissue_Signals_and_Biological_Processes_in_Chronic_Inflammation_and/1356 https://www.frontiersin.org/research-topics/3329/macrophages-role-in-integrating-tissue-signals-and-biological-processes-in-chronic-inflammation-and Frontiers Media SA 10.3389/978-2-88945-332-0 10.3389/978-2-88945-332-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889453320 104 open access |
| spellingShingle | R5-920 RC581-607 macrophage subtypes inflammation chronic diseases fibrosis thema EDItEUR::M Medicine and Nursing Tarcio Teodoro Braga Niels Olsen Saraiva Camara Ana Paula Lepique Ivan C. Moura Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
| title | Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
| title_full | Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
| title_fullStr | Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
| title_full_unstemmed | Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
| title_short | Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
| title_sort | macrophages role in integrating tissue signals and biological processes in chronic inflammation and fibrosis |
| topic | R5-920 RC581-607 macrophage subtypes inflammation chronic diseases fibrosis thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 macrophage subtypes inflammation chronic diseases fibrosis thema EDItEUR::M Medicine and Nursing |
| url | 25634 |
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