Major Histocompatibility Complex (MHC) in Health and Disease
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually...
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| Format: | Online |
| Język: | angielski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Dostęp online: | 44737 |
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| _version_ | 1869523093448294400 |
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| author | Shiina, Takashi Dijkstra, Johannes M. Kulski, Jerzy K. |
| author_browse | Dijkstra, Johannes M. Kulski, Jerzy K. Shiina, Takashi |
| author_facet | Shiina, Takashi Dijkstra, Johannes M. Kulski, Jerzy K. |
| author_sort | Shiina, Takashi |
| collection | Directory of Open Access Books |
| description | The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species. |
| format | Online |
| id | doab-20.500.12854ir-52604 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-526042024-04-05T12:32:48Z Major Histocompatibility Complex (MHC) in Health and Disease Shiina, Takashi Dijkstra, Johannes M. Kulski, Jerzy K. QH301-705.5 Q1-390 HCP5 n/a camels MHC STK19 major histocompatibility complex human papillomavirus (HPV) T-cell receptor T1DGC bottleneck micro-mini-pigs life history computational analysis hepatocellular carcinoma phase Bactrian camel NSDK melanoma antigen autoimmune disease RD selection disease resistance autoimmunity ancestral haplotype Ski complex DXO high-throughput sequencing conservation genetics SVA lncRNA ankylosing spondylitis MHC genes viral peptides competing endogenous RNA (ceRNA) astrogliosis birds long-fragment super haplotype SNP RLR HLA polymorphism 5??3? RNA decay expression 3??5? mRNA turnover orthology long-read sequencing disease association dromedary polyomavirus MHC-II-associated sperm-egg recognition experimental medicine single nucleotide polymorphism (SNP) fish SKIV2L production trait molecular dynamics simulation Macaca fascicularis human endogenous retrovirus (HERV) concerted evolution polymorphism Old World camels MHC polymorphism protocol nonclassical gene duplication microglial reaction human leukocyte antigen-E SKI2W quantitative trait loci (QTL) studies antiviral immunity human immunodeficiency virus (HIV) founder effect giant panda domain movements BK virus promoter-proximal transcriptional pause type 1 diabetes (T1D) RP1 miR1236 KIR synaptic covering swine leukocyte antigen cynomolgus macaque HLA kidney transplantation ?2m knockout mice DOM3Z interferon ? ethnic populations in China ecology KIR–HLA pairs exosomes major histocompatibility complex (MHC) MHC-I-based mother-fetus recognition RNA quality control autoimmune diseases NELF-E haplotype genetic drift evolution nonhuman primate models HLA-B27 PNS/CNS interface risk genes pedigree MHC-I- and MHC-II-dependent inter-individual recognition regulation crested ibis reproductive performance nephropathy cancer nuclear kinase trichohepatoenteric syndrome thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species. 2021-02-11T18:34:35Z 2021-02-11T18:34:35Z 2020-04-07 23:07:08 2020 book 44737 9783039280728 9783039280735 https://directory.doabooks.org/handle/20.500.12854/52604 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2011 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-073-5 10.3390/books978-3-03928-073-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039280728 9783039280735 375 open access |
| spellingShingle | QH301-705.5 Q1-390 HCP5 n/a camels MHC STK19 major histocompatibility complex human papillomavirus (HPV) T-cell receptor T1DGC bottleneck micro-mini-pigs life history computational analysis hepatocellular carcinoma phase Bactrian camel NSDK melanoma antigen autoimmune disease RD selection disease resistance autoimmunity ancestral haplotype Ski complex DXO high-throughput sequencing conservation genetics SVA lncRNA ankylosing spondylitis MHC genes viral peptides competing endogenous RNA (ceRNA) astrogliosis birds long-fragment super haplotype SNP RLR HLA polymorphism 5??3? RNA decay expression 3??5? mRNA turnover orthology long-read sequencing disease association dromedary polyomavirus MHC-II-associated sperm-egg recognition experimental medicine single nucleotide polymorphism (SNP) fish SKIV2L production trait molecular dynamics simulation Macaca fascicularis human endogenous retrovirus (HERV) concerted evolution polymorphism Old World camels MHC polymorphism protocol nonclassical gene duplication microglial reaction human leukocyte antigen-E SKI2W quantitative trait loci (QTL) studies antiviral immunity human immunodeficiency virus (HIV) founder effect giant panda domain movements BK virus promoter-proximal transcriptional pause type 1 diabetes (T1D) RP1 miR1236 KIR synaptic covering swine leukocyte antigen cynomolgus macaque HLA kidney transplantation ?2m knockout mice DOM3Z interferon ? ethnic populations in China ecology KIR–HLA pairs exosomes major histocompatibility complex (MHC) MHC-I-based mother-fetus recognition RNA quality control autoimmune diseases NELF-E haplotype genetic drift evolution nonhuman primate models HLA-B27 PNS/CNS interface risk genes pedigree MHC-I- and MHC-II-dependent inter-individual recognition regulation crested ibis reproductive performance nephropathy cancer nuclear kinase trichohepatoenteric syndrome thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Shiina, Takashi Dijkstra, Johannes M. Kulski, Jerzy K. Major Histocompatibility Complex (MHC) in Health and Disease |
| title | Major Histocompatibility Complex (MHC) in Health and Disease |
| title_full | Major Histocompatibility Complex (MHC) in Health and Disease |
| title_fullStr | Major Histocompatibility Complex (MHC) in Health and Disease |
| title_full_unstemmed | Major Histocompatibility Complex (MHC) in Health and Disease |
| title_short | Major Histocompatibility Complex (MHC) in Health and Disease |
| title_sort | major histocompatibility complex mhc in health and disease |
| topic | QH301-705.5 Q1-390 HCP5 n/a camels MHC STK19 major histocompatibility complex human papillomavirus (HPV) T-cell receptor T1DGC bottleneck micro-mini-pigs life history computational analysis hepatocellular carcinoma phase Bactrian camel NSDK melanoma antigen autoimmune disease RD selection disease resistance autoimmunity ancestral haplotype Ski complex DXO high-throughput sequencing conservation genetics SVA lncRNA ankylosing spondylitis MHC genes viral peptides competing endogenous RNA (ceRNA) astrogliosis birds long-fragment super haplotype SNP RLR HLA polymorphism 5??3? RNA decay expression 3??5? mRNA turnover orthology long-read sequencing disease association dromedary polyomavirus MHC-II-associated sperm-egg recognition experimental medicine single nucleotide polymorphism (SNP) fish SKIV2L production trait molecular dynamics simulation Macaca fascicularis human endogenous retrovirus (HERV) concerted evolution polymorphism Old World camels MHC polymorphism protocol nonclassical gene duplication microglial reaction human leukocyte antigen-E SKI2W quantitative trait loci (QTL) studies antiviral immunity human immunodeficiency virus (HIV) founder effect giant panda domain movements BK virus promoter-proximal transcriptional pause type 1 diabetes (T1D) RP1 miR1236 KIR synaptic covering swine leukocyte antigen cynomolgus macaque HLA kidney transplantation ?2m knockout mice DOM3Z interferon ? ethnic populations in China ecology KIR–HLA pairs exosomes major histocompatibility complex (MHC) MHC-I-based mother-fetus recognition RNA quality control autoimmune diseases NELF-E haplotype genetic drift evolution nonhuman primate models HLA-B27 PNS/CNS interface risk genes pedigree MHC-I- and MHC-II-dependent inter-individual recognition regulation crested ibis reproductive performance nephropathy cancer nuclear kinase trichohepatoenteric syndrome thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Q1-390 HCP5 n/a camels MHC STK19 major histocompatibility complex human papillomavirus (HPV) T-cell receptor T1DGC bottleneck micro-mini-pigs life history computational analysis hepatocellular carcinoma phase Bactrian camel NSDK melanoma antigen autoimmune disease RD selection disease resistance autoimmunity ancestral haplotype Ski complex DXO high-throughput sequencing conservation genetics SVA lncRNA ankylosing spondylitis MHC genes viral peptides competing endogenous RNA (ceRNA) astrogliosis birds long-fragment super haplotype SNP RLR HLA polymorphism 5??3? RNA decay expression 3??5? mRNA turnover orthology long-read sequencing disease association dromedary polyomavirus MHC-II-associated sperm-egg recognition experimental medicine single nucleotide polymorphism (SNP) fish SKIV2L production trait molecular dynamics simulation Macaca fascicularis human endogenous retrovirus (HERV) concerted evolution polymorphism Old World camels MHC polymorphism protocol nonclassical gene duplication microglial reaction human leukocyte antigen-E SKI2W quantitative trait loci (QTL) studies antiviral immunity human immunodeficiency virus (HIV) founder effect giant panda domain movements BK virus promoter-proximal transcriptional pause type 1 diabetes (T1D) RP1 miR1236 KIR synaptic covering swine leukocyte antigen cynomolgus macaque HLA kidney transplantation ?2m knockout mice DOM3Z interferon ? ethnic populations in China ecology KIR–HLA pairs exosomes major histocompatibility complex (MHC) MHC-I-based mother-fetus recognition RNA quality control autoimmune diseases NELF-E haplotype genetic drift evolution nonhuman primate models HLA-B27 PNS/CNS interface risk genes pedigree MHC-I- and MHC-II-dependent inter-individual recognition regulation crested ibis reproductive performance nephropathy cancer nuclear kinase trichohepatoenteric syndrome thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 44737 |
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