Manipulation of the host cell by viral auxiliary proteins
Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of...
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| Format: | Online |
| Language: | English |
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Frontiers Media SA
2021
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| Online Access: | 17673 |
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| author | Nadine Laguette Monsef Benkirane |
| author_browse | Monsef Benkirane Nadine Laguette |
| author_facet | Nadine Laguette Monsef Benkirane |
| author_sort | Nadine Laguette |
| collection | Directory of Open Access Books |
| description | Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of cellular factors/pathways to the benefit of the viral life cycle. To gain a foothold into host cells, HIV has to take advantage of available cellular factories and overcome the numerous potential blocks opposed to its replication while ensuring cellular survival. Viral auxiliary proteins are a perfect paradigm to illustrate the complexity of the relationship between HIV and its host. Although these accessory proteins are mostly unnecessary for viral replication in permissive cells in vitro, they play a crucial role in regulating viral spread ex vivo in non-permissive cells and in vivo in hosts. Most accessory proteins are pleiotropic and instrumental in the counteraction of restriction factors and proteins involved in innate immune response. Several proteins of the "intrinsic" immune system that detect the presence of the assailant and initiate a subsequent immune response, as well as restriction factors that are directly devoted to arresting the replication cycle at precise steps have been characterized. Despite the numerous cellular mechanisms dedicated to preventing viral replication, HIV is able to efficiently replicate in humans. Indeed, as a master regulator of cellular machineries and processes, not only has HIV evolved strategies to avoid triggering of pattern recognition receptors, but HIV has also elaborated ways to counteract host restriction factors, thereby overcoming the hurdles that oppose efficient replication. This review collection is dedicated to the manipulation of host cells by HIV-1 and HIV-2, with a particular focus on viral accessory proteins. |
| format | Online |
| id | doab-20.500.12854ir-52684 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-526842024-04-05T17:30:59Z Manipulation of the host cell by viral auxiliary proteins Nadine Laguette Monsef Benkirane QR1-502 Q1-390 HIV intracellular sensors restriction factors intrinsic immune system Viral accessory proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of cellular factors/pathways to the benefit of the viral life cycle. To gain a foothold into host cells, HIV has to take advantage of available cellular factories and overcome the numerous potential blocks opposed to its replication while ensuring cellular survival. Viral auxiliary proteins are a perfect paradigm to illustrate the complexity of the relationship between HIV and its host. Although these accessory proteins are mostly unnecessary for viral replication in permissive cells in vitro, they play a crucial role in regulating viral spread ex vivo in non-permissive cells and in vivo in hosts. Most accessory proteins are pleiotropic and instrumental in the counteraction of restriction factors and proteins involved in innate immune response. Several proteins of the "intrinsic" immune system that detect the presence of the assailant and initiate a subsequent immune response, as well as restriction factors that are directly devoted to arresting the replication cycle at precise steps have been characterized. Despite the numerous cellular mechanisms dedicated to preventing viral replication, HIV is able to efficiently replicate in humans. Indeed, as a master regulator of cellular machineries and processes, not only has HIV evolved strategies to avoid triggering of pattern recognition receptors, but HIV has also elaborated ways to counteract host restriction factors, thereby overcoming the hurdles that oppose efficient replication. This review collection is dedicated to the manipulation of host cells by HIV-1 and HIV-2, with a particular focus on viral accessory proteins. 2021-02-11T18:41:12Z 2021-02-11T18:41:12Z 2015-11-16 15:44:59 2015 book 17673 16648714 9782889194841 https://directory.doabooks.org/handle/20.500.12854/52684 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Manipulation_of_the_host_cell_by_viral_auxiliary_proteins/518#nogo http://journal.frontiersin.org/researchtopic/1634/manipulation-of-the-host-cell-by-viral-auxiliary-proteins Frontiers Media SA 10.3389/978-2-88919-484-1 10.3389/978-2-88919-484-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194841 118 open access |
| spellingShingle | QR1-502 Q1-390 HIV intracellular sensors restriction factors intrinsic immune system Viral accessory proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Nadine Laguette Monsef Benkirane Manipulation of the host cell by viral auxiliary proteins |
| title | Manipulation of the host cell by viral auxiliary proteins |
| title_full | Manipulation of the host cell by viral auxiliary proteins |
| title_fullStr | Manipulation of the host cell by viral auxiliary proteins |
| title_full_unstemmed | Manipulation of the host cell by viral auxiliary proteins |
| title_short | Manipulation of the host cell by viral auxiliary proteins |
| title_sort | manipulation of the host cell by viral auxiliary proteins |
| topic | QR1-502 Q1-390 HIV intracellular sensors restriction factors intrinsic immune system Viral accessory proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | QR1-502 Q1-390 HIV intracellular sensors restriction factors intrinsic immune system Viral accessory proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | 17673 |
| work_keys_str_mv | AT nadinelaguette manipulationofthehostcellbyviralauxiliaryproteins AT monsefbenkirane manipulationofthehostcellbyviralauxiliaryproteins |