Marine Glycosides
In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse a...
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| フォーマット: | Online |
| 言語: | 英語 |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| オンライン･アクセス: | 33318 |
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| _version_ | 1869520996818485248 |
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| author | Adrian, Thomas E Sarabia, Francisco Cheng-Sanchez, Ivan |
| author_browse | Adrian, Thomas E Cheng-Sanchez, Ivan Sarabia, Francisco |
| author_facet | Adrian, Thomas E Sarabia, Francisco Cheng-Sanchez, Ivan |
| author_sort | Adrian, Thomas E |
| collection | Directory of Open Access Books |
| description | In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.<false,>The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.<false,>This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones. |
| format | Online |
| id | doab-20.500.12854ir-52777 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-527772024-03-30T23:22:46Z Marine Glycosides Adrian, Thomas E Sarabia, Francisco Cheng-Sanchez, Ivan R5-920 RM1-950 leukemia angucycline glycosides steroidal glycoside antitumor deep-sea antibacterial anticoagulant saquayamycin marine invertebrate triterpene glycoside glycosides carbohydrate polyhydroxysteroidal glycoside glycosphingolipids triterpene glycosides cytotoxic activity metabolite profiling magnumosides antioxidant angiogenesis Poecillastra compressa cucumarioside antifungal nonholostane Eupentacta fraudatrix angucycline urdamycin marine ginseng sponge antimicrobial holostane apoptosis cholesterol sulfate SMMC-7721 metastases Culcita novaeguineae natural products marine organisms liquid chromatography–tandem mass spectrometry anti-inflammatory tumor growth mass spectrometry ESI total synthesis starfish sea cucumber cytotoxic cytotoxicity saponins Neothyonidium magnum glycolipids glycoglycerolipids Conus pulicarius MALDI Streptomyces glycoside radioactive irradiation frondoside A LC-MS invasion Holothuroidea saponin bioactive compounds cancer structure elucidation mangrove-derived Streptomyces thema EDItEUR::M Medicine and Nursing In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.<false,>The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.<false,>This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones. 2021-02-11T18:48:08Z 2021-02-11T18:48:08Z 2019-05-09 17:16:14 2019 book 33318 9783038979036 9783038979029 https://directory.doabooks.org/handle/20.500.12854/52777 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1283 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-903-6 10.3390/books978-3-03897-903-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038979036 9783038979029 264 open access |
| spellingShingle | R5-920 RM1-950 leukemia angucycline glycosides steroidal glycoside antitumor deep-sea antibacterial anticoagulant saquayamycin marine invertebrate triterpene glycoside glycosides carbohydrate polyhydroxysteroidal glycoside glycosphingolipids triterpene glycosides cytotoxic activity metabolite profiling magnumosides antioxidant angiogenesis Poecillastra compressa cucumarioside antifungal nonholostane Eupentacta fraudatrix angucycline urdamycin marine ginseng sponge antimicrobial holostane apoptosis cholesterol sulfate SMMC-7721 metastases Culcita novaeguineae natural products marine organisms liquid chromatography–tandem mass spectrometry anti-inflammatory tumor growth mass spectrometry ESI total synthesis starfish sea cucumber cytotoxic cytotoxicity saponins Neothyonidium magnum glycolipids glycoglycerolipids Conus pulicarius MALDI Streptomyces glycoside radioactive irradiation frondoside A LC-MS invasion Holothuroidea saponin bioactive compounds cancer structure elucidation mangrove-derived Streptomyces thema EDItEUR::M Medicine and Nursing Adrian, Thomas E Sarabia, Francisco Cheng-Sanchez, Ivan Marine Glycosides |
| title | Marine Glycosides |
| title_full | Marine Glycosides |
| title_fullStr | Marine Glycosides |
| title_full_unstemmed | Marine Glycosides |
| title_short | Marine Glycosides |
| title_sort | marine glycosides |
| topic | R5-920 RM1-950 leukemia angucycline glycosides steroidal glycoside antitumor deep-sea antibacterial anticoagulant saquayamycin marine invertebrate triterpene glycoside glycosides carbohydrate polyhydroxysteroidal glycoside glycosphingolipids triterpene glycosides cytotoxic activity metabolite profiling magnumosides antioxidant angiogenesis Poecillastra compressa cucumarioside antifungal nonholostane Eupentacta fraudatrix angucycline urdamycin marine ginseng sponge antimicrobial holostane apoptosis cholesterol sulfate SMMC-7721 metastases Culcita novaeguineae natural products marine organisms liquid chromatography–tandem mass spectrometry anti-inflammatory tumor growth mass spectrometry ESI total synthesis starfish sea cucumber cytotoxic cytotoxicity saponins Neothyonidium magnum glycolipids glycoglycerolipids Conus pulicarius MALDI Streptomyces glycoside radioactive irradiation frondoside A LC-MS invasion Holothuroidea saponin bioactive compounds cancer structure elucidation mangrove-derived Streptomyces thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RM1-950 leukemia angucycline glycosides steroidal glycoside antitumor deep-sea antibacterial anticoagulant saquayamycin marine invertebrate triterpene glycoside glycosides carbohydrate polyhydroxysteroidal glycoside glycosphingolipids triterpene glycosides cytotoxic activity metabolite profiling magnumosides antioxidant angiogenesis Poecillastra compressa cucumarioside antifungal nonholostane Eupentacta fraudatrix angucycline urdamycin marine ginseng sponge antimicrobial holostane apoptosis cholesterol sulfate SMMC-7721 metastases Culcita novaeguineae natural products marine organisms liquid chromatography–tandem mass spectrometry anti-inflammatory tumor growth mass spectrometry ESI total synthesis starfish sea cucumber cytotoxic cytotoxicity saponins Neothyonidium magnum glycolipids glycoglycerolipids Conus pulicarius MALDI Streptomyces glycoside radioactive irradiation frondoside A LC-MS invasion Holothuroidea saponin bioactive compounds cancer structure elucidation mangrove-derived Streptomyces thema EDItEUR::M Medicine and Nursing |
| url | 33318 |
| work_keys_str_mv | AT adrianthomase marineglycosides AT sarabiafrancisco marineglycosides AT chengsanchezivan marineglycosides |