Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies
The invasive character of a primary cancer is greatly dependent on numerous interactions between tumor cells and their extracellular surroundings. Matricellular receptors are defined as (cell-surface) receptors that bind extracellular matrix (ECM) structural proteins and soluble factors dynamically...
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| Автори: | , , |
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| Формат: | Online |
| Мова: | Англійська |
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Frontiers Media SA
2021
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| Онлайн доступ: | 25544 |
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| _version_ | 1869521942735749120 |
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| author | Herve Emonard Stephane Dedieu Laurent Duca |
| author_browse | Herve Emonard Laurent Duca Stephane Dedieu |
| author_facet | Herve Emonard Stephane Dedieu Laurent Duca |
| author_sort | Herve Emonard |
| collection | Directory of Open Access Books |
| description | The invasive character of a primary cancer is greatly dependent on numerous interactions between tumor cells and their extracellular surroundings. Matricellular receptors are defined as (cell-surface) receptors that bind extracellular matrix (ECM) structural proteins and soluble factors dynamically acting on ECM homeostasis. Matricellular receptors mediate numerous signalings from the extracellular environment to cell nucleus and drive main biological functions that are cell growth, survival and migration. Numerous data from the last decade evidence that matricellular receptors are biosensors that allow to a tumor cell answering to microenvironmental variations, and in this sense they are important contributors to tumor cell malignancy. Matricellular receptors represent thus valuable targets for the development of original anti-cancer strategies. Original reports, bibliographic reviews or hypotheses are welcome to improve the basic knowledge of matricellular receptor properties, their spatio-temporal regulation, the dynamic formation of complex receptors and the impact of such interactions on the invasive properties of tumor cells. Biological, biophysical and pharmacological, as well as in silico contributions will be appreciated. |
| format | Online |
| id | doab-20.500.12854ir-52887 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-528872024-04-01T14:14:57Z Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies Herve Emonard Stephane Dedieu Laurent Duca RM1-950 Q1-390 disco Anti-cancer target thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology The invasive character of a primary cancer is greatly dependent on numerous interactions between tumor cells and their extracellular surroundings. Matricellular receptors are defined as (cell-surface) receptors that bind extracellular matrix (ECM) structural proteins and soluble factors dynamically acting on ECM homeostasis. Matricellular receptors mediate numerous signalings from the extracellular environment to cell nucleus and drive main biological functions that are cell growth, survival and migration. Numerous data from the last decade evidence that matricellular receptors are biosensors that allow to a tumor cell answering to microenvironmental variations, and in this sense they are important contributors to tumor cell malignancy. Matricellular receptors represent thus valuable targets for the development of original anti-cancer strategies. Original reports, bibliographic reviews or hypotheses are welcome to improve the basic knowledge of matricellular receptor properties, their spatio-temporal regulation, the dynamic formation of complex receptors and the impact of such interactions on the invasive properties of tumor cells. Biological, biophysical and pharmacological, as well as in silico contributions will be appreciated. 2021-02-11T18:56:04Z 2021-02-11T18:56:04Z 2018-02-27 16:16:44 2016 book 25544 16648714 9782889450244 https://directory.doabooks.org/handle/20.500.12854/52887 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Matricellular_Receptors_as_Potential_Targets_in_Anti-Cancer_Therapeutic_Strategies/1068#nogo http://journal.frontiersin.org/researchtopic/3665/matricellular-receptors-as-potential-targets-in-anti-cancer-therapeutic-strategies Frontiers Media SA 10.3389/978-2-88945-024-4 10.3389/978-2-88945-024-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889450244 129 open access |
| spellingShingle | RM1-950 Q1-390 disco Anti-cancer target thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Herve Emonard Stephane Dedieu Laurent Duca Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies |
| title | Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies |
| title_full | Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies |
| title_fullStr | Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies |
| title_full_unstemmed | Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies |
| title_short | Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies |
| title_sort | matricellular receptors as potential targets in anti cancer therapeutic strategies |
| topic | RM1-950 Q1-390 disco Anti-cancer target thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 Q1-390 disco Anti-cancer target thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 25544 |
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