Mechanisms of Adiponectin Action
The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multime...
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| Format: | Online |
| Idioma: | anglès |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Accés en línia: | 35927 |
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| _version_ | 1869518337156841472 |
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| author | Fiaschi, Tania |
| author_browse | Fiaschi, Tania |
| author_facet | Fiaschi, Tania |
| author_sort | Fiaschi, Tania |
| collection | Directory of Open Access Books |
| description | The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions. |
| format | Online |
| id | doab-20.500.12854ir-52942 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-529422023-12-20T15:54:27Z Mechanisms of Adiponectin Action Fiaschi, Tania HM401-1281 H1-99 acidic and rich in cysteine (SPARC) n/a regeneration fertility pig endocrine cancer NGF? reproductive tract neuritogenesis skeletal muscle matricellular proteins adiponectin isoforms obesity atherosclerosis hair growth-related factor ovarian cancer adipose tissue AdipoRon extracellular signal-regulated kinase (ERK) PC12 cells endometrial cancer AMPK metabolism adiponectin transcriptome exercise training inflammation BIAcore muscle adipokines human follicular dermal papilla cell estrogen receptor endometrium adiponectin inducer breast cancer implantation microarray Secreted protein adipogenesis kojyl cinnamate ester derivative cell signaling lipotoxicity cervix cancer cancer cholesterol efflux myopathies diabetes bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFP Social interaction The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions. 2021-02-11T19:01:09Z 2021-02-11T19:01:09Z 2019-08-28 11:21:27 2019 book 35927 9783039212453 9783039212460 https://directory.doabooks.org/handle/20.500.12854/52942 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1451 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-246-0 10.3390/books978-3-03921-246-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039212453 9783039212460 222 open access |
| spellingShingle | HM401-1281 H1-99 acidic and rich in cysteine (SPARC) n/a regeneration fertility pig endocrine cancer NGF? reproductive tract neuritogenesis skeletal muscle matricellular proteins adiponectin isoforms obesity atherosclerosis hair growth-related factor ovarian cancer adipose tissue AdipoRon extracellular signal-regulated kinase (ERK) PC12 cells endometrial cancer AMPK metabolism adiponectin transcriptome exercise training inflammation BIAcore muscle adipokines human follicular dermal papilla cell estrogen receptor endometrium adiponectin inducer breast cancer implantation microarray Secreted protein adipogenesis kojyl cinnamate ester derivative cell signaling lipotoxicity cervix cancer cancer cholesterol efflux myopathies diabetes bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFP Social interaction Fiaschi, Tania Mechanisms of Adiponectin Action |
| title | Mechanisms of Adiponectin Action |
| title_full | Mechanisms of Adiponectin Action |
| title_fullStr | Mechanisms of Adiponectin Action |
| title_full_unstemmed | Mechanisms of Adiponectin Action |
| title_short | Mechanisms of Adiponectin Action |
| title_sort | mechanisms of adiponectin action |
| topic | HM401-1281 H1-99 acidic and rich in cysteine (SPARC) n/a regeneration fertility pig endocrine cancer NGF? reproductive tract neuritogenesis skeletal muscle matricellular proteins adiponectin isoforms obesity atherosclerosis hair growth-related factor ovarian cancer adipose tissue AdipoRon extracellular signal-regulated kinase (ERK) PC12 cells endometrial cancer AMPK metabolism adiponectin transcriptome exercise training inflammation BIAcore muscle adipokines human follicular dermal papilla cell estrogen receptor endometrium adiponectin inducer breast cancer implantation microarray Secreted protein adipogenesis kojyl cinnamate ester derivative cell signaling lipotoxicity cervix cancer cancer cholesterol efflux myopathies diabetes bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFP Social interaction |
| topic_facet | HM401-1281 H1-99 acidic and rich in cysteine (SPARC) n/a regeneration fertility pig endocrine cancer NGF? reproductive tract neuritogenesis skeletal muscle matricellular proteins adiponectin isoforms obesity atherosclerosis hair growth-related factor ovarian cancer adipose tissue AdipoRon extracellular signal-regulated kinase (ERK) PC12 cells endometrial cancer AMPK metabolism adiponectin transcriptome exercise training inflammation BIAcore muscle adipokines human follicular dermal papilla cell estrogen receptor endometrium adiponectin inducer breast cancer implantation microarray Secreted protein adipogenesis kojyl cinnamate ester derivative cell signaling lipotoxicity cervix cancer cancer cholesterol efflux myopathies diabetes bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFP Social interaction |
| url | 35927 |
| work_keys_str_mv | AT fiaschitania mechanismsofadiponectinaction |