Mechanisms of Innate Neuroprotection
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. I...
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| Format: | Online |
| Sprog: | engelsk |
| Udgivet: |
Frontiers Media SA
2021
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| Fag: | |
| Online adgang: | 18316 |
| Tags: |
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| _version_ | 1869530992171024384 |
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| author | Giuseppe Pignataro |
| author_browse | Giuseppe Pignataro |
| author_facet | Giuseppe Pignataro |
| author_sort | Giuseppe Pignataro |
| collection | Directory of Open Access Books |
| description | As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans. |
| format | Online |
| id | doab-20.500.12854ir-52944 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-529442024-03-31T13:10:17Z Mechanisms of Innate Neuroprotection Giuseppe Pignataro R5-920 RC346-429 RC321-571 Q1-390 Neuroprotection postconditioning NCX Stroke seizure miRNA Alzheimer preconditioning thema EDItEUR::M Medicine and Nursing As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans. 2021-02-11T19:01:13Z 2021-02-11T19:01:13Z 2016-01-19 14:05:46 2016 book 18316 16648714 9782889199297 https://directory.doabooks.org/handle/20.500.12854/52944 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Mechanisms_of_Innate_Neuroprotection/934 http://journal.frontiersin.org/researchtopic/2693/mechanisms-of-innate-neuroprotection Frontiers Media SA 10.3389/978-2-88919-929-7 10.3389/978-2-88919-929-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199297 138 open access |
| spellingShingle | R5-920 RC346-429 RC321-571 Q1-390 Neuroprotection postconditioning NCX Stroke seizure miRNA Alzheimer preconditioning thema EDItEUR::M Medicine and Nursing Giuseppe Pignataro Mechanisms of Innate Neuroprotection |
| title | Mechanisms of Innate Neuroprotection |
| title_full | Mechanisms of Innate Neuroprotection |
| title_fullStr | Mechanisms of Innate Neuroprotection |
| title_full_unstemmed | Mechanisms of Innate Neuroprotection |
| title_short | Mechanisms of Innate Neuroprotection |
| title_sort | mechanisms of innate neuroprotection |
| topic | R5-920 RC346-429 RC321-571 Q1-390 Neuroprotection postconditioning NCX Stroke seizure miRNA Alzheimer preconditioning thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC346-429 RC321-571 Q1-390 Neuroprotection postconditioning NCX Stroke seizure miRNA Alzheimer preconditioning thema EDItEUR::M Medicine and Nursing |
| url | 18316 |
| work_keys_str_mv | AT giuseppepignataro mechanismsofinnateneuroprotection |