Mechanisms of Neuronal Migration during Corticogenesis
The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , |
|---|---|
| Fformat: | Online |
| Iaith: | Saesneg |
| Cyhoeddwyd: |
Frontiers Media SA
2021
|
| Pynciau: | |
| Mynediad Ar-lein: | 18273 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|
| _version_ | 1869525131797200896 |
|---|---|
| author | Chiaki Ohtaka-Maruyama Kazunori Nakajima Nobuaki Maeda Alessandra Pierani |
| author_browse | Alessandra Pierani Chiaki Ohtaka-Maruyama Kazunori Nakajima Nobuaki Maeda |
| author_facet | Chiaki Ohtaka-Maruyama Kazunori Nakajima Nobuaki Maeda Alessandra Pierani |
| author_sort | Chiaki Ohtaka-Maruyama |
| collection | Directory of Open Access Books |
| description | The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis. |
| format | Online |
| id | doab-20.500.12854ir-52949 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-529492024-04-05T17:30:57Z Mechanisms of Neuronal Migration during Corticogenesis Chiaki Ohtaka-Maruyama Kazunori Nakajima Nobuaki Maeda Alessandra Pierani RC321-571 Q1-390 neurodevelopmental diseases corticogenesis neuronal migration Neuronal polarization radial glial cells Neurogenesis Cortical evolution subplate thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis. 2021-02-11T19:01:24Z 2021-02-11T19:01:24Z 2016-01-19 14:05:46 2016 book 18273 16648714 9782889198863 https://directory.doabooks.org/handle/20.500.12854/52949 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Mechanisms_of_Neuronal_Migration_during_Corticogenesis/922#nogo http://journal.frontiersin.org/researchtopic/2965/mechanisms-of-neuronal-migration-during-corticogenesis Frontiers Media SA 10.3389/978-2-88919-886-3 10.3389/978-2-88919-886-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198863 183 open access |
| spellingShingle | RC321-571 Q1-390 neurodevelopmental diseases corticogenesis neuronal migration Neuronal polarization radial glial cells Neurogenesis Cortical evolution subplate thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Chiaki Ohtaka-Maruyama Kazunori Nakajima Nobuaki Maeda Alessandra Pierani Mechanisms of Neuronal Migration during Corticogenesis |
| title | Mechanisms of Neuronal Migration during Corticogenesis |
| title_full | Mechanisms of Neuronal Migration during Corticogenesis |
| title_fullStr | Mechanisms of Neuronal Migration during Corticogenesis |
| title_full_unstemmed | Mechanisms of Neuronal Migration during Corticogenesis |
| title_short | Mechanisms of Neuronal Migration during Corticogenesis |
| title_sort | mechanisms of neuronal migration during corticogenesis |
| topic | RC321-571 Q1-390 neurodevelopmental diseases corticogenesis neuronal migration Neuronal polarization radial glial cells Neurogenesis Cortical evolution subplate thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 neurodevelopmental diseases corticogenesis neuronal migration Neuronal polarization radial glial cells Neurogenesis Cortical evolution subplate thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18273 |
| work_keys_str_mv | AT chiakiohtakamaruyama mechanismsofneuronalmigrationduringcorticogenesis AT kazunorinakajima mechanismsofneuronalmigrationduringcorticogenesis AT nobuakimaeda mechanismsofneuronalmigrationduringcorticogenesis AT alessandrapierani mechanismsofneuronalmigrationduringcorticogenesis |