Mesothelial Physiology and Pathophysiology
The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides prov...
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| Format: | Online |
| Language: | English |
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Frontiers Media SA
2021
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| Online Access: | 31951 |
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| _version_ | 1869520512548339712 |
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| author | Sotirios G. Zarogiannis |
| author_browse | Sotirios G. Zarogiannis |
| author_facet | Sotirios G. Zarogiannis |
| author_sort | Sotirios G. Zarogiannis |
| collection | Directory of Open Access Books |
| description | The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers. |
| format | Online |
| id | doab-20.500.12854ir-53210 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-532102024-03-31T22:45:09Z Mesothelial Physiology and Pathophysiology Sotirios G. Zarogiannis QP1-981 Q1-390 Mesothelium Serosal Membranes Physiology Pleura Peritoneum Pericardium thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers. 2021-02-11T19:19:03Z 2021-02-11T19:19:03Z 2019-01-23 14:53:42 2018 book 31951 16648714 9782889455416 https://directory.doabooks.org/handle/20.500.12854/53210 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/2153/mesothelial-physiology-and-pathophysiology Frontiers Media SA 10.3389/978-2-88945-541-6 10.3389/978-2-88945-541-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455416 81 open access |
| spellingShingle | QP1-981 Q1-390 Mesothelium Serosal Membranes Physiology Pleura Peritoneum Pericardium thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Sotirios G. Zarogiannis Mesothelial Physiology and Pathophysiology |
| title | Mesothelial Physiology and Pathophysiology |
| title_full | Mesothelial Physiology and Pathophysiology |
| title_fullStr | Mesothelial Physiology and Pathophysiology |
| title_full_unstemmed | Mesothelial Physiology and Pathophysiology |
| title_short | Mesothelial Physiology and Pathophysiology |
| title_sort | mesothelial physiology and pathophysiology |
| topic | QP1-981 Q1-390 Mesothelium Serosal Membranes Physiology Pleura Peritoneum Pericardium thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 Mesothelium Serosal Membranes Physiology Pleura Peritoneum Pericardium thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 31951 |
| work_keys_str_mv | AT sotiriosgzarogiannis mesothelialphysiologyandpathophysiology |