Mesothelioma Heterogeneity: Potential Mechanisms
Mesothelioma is a rare aggressive cancer that develops from the mesothelium. Recent molecular analyses have defined four different types of mesothelioma based on gene expression and two major molecularly-defined groups based on prognosis. In this volume, potential mechanisms causing this heterogenei...
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| Format: | Online |
| Język: | angielski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | 29847 |
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| _version_ | 1869527664874749952 |
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| author | Emanuela Felley-Bosco (Ed.) |
| author_browse | Emanuela Felley-Bosco (Ed.) |
| author_facet | Emanuela Felley-Bosco (Ed.) |
| author_sort | Emanuela Felley-Bosco (Ed.) |
| collection | Directory of Open Access Books |
| description | Mesothelioma is a rare aggressive cancer that develops from the mesothelium. Recent molecular analyses have defined four different types of mesothelioma based on gene expression and two major molecularly-defined groups based on prognosis. In this volume, potential mechanisms causing this heterogeneity are explored. The different chapters include heterogeneity learned from experimental animal models in NF2/Hippo pathway signaling, stem cell signaling pathways, the tumor microenvironment, and micro RNA secretome. Novel aspects deserving attention such as the implication of long, non-coding RNA in disease heterogeneity are described. The volume also includes the description of tools useful to address some specific questions such as an assessment of the copy number variations of two tumor suppressors frequently mutated in mesothelioma or an investigation of Macrophage Inhibition Factor signaling in mesothelioma. |
| format | Online |
| id | doab-20.500.12854ir-53211 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-532112024-04-05T12:33:23Z Mesothelioma Heterogeneity: Potential Mechanisms Emanuela Felley-Bosco (Ed.) QH301-705.5 RC254-282 NF2 signaling pathway tumor microenvironment mesothelioma experimental mesothelioma models thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Mesothelioma is a rare aggressive cancer that develops from the mesothelium. Recent molecular analyses have defined four different types of mesothelioma based on gene expression and two major molecularly-defined groups based on prognosis. In this volume, potential mechanisms causing this heterogeneity are explored. The different chapters include heterogeneity learned from experimental animal models in NF2/Hippo pathway signaling, stem cell signaling pathways, the tumor microenvironment, and micro RNA secretome. Novel aspects deserving attention such as the implication of long, non-coding RNA in disease heterogeneity are described. The volume also includes the description of tools useful to address some specific questions such as an assessment of the copy number variations of two tumor suppressors frequently mutated in mesothelioma or an investigation of Macrophage Inhibition Factor signaling in mesothelioma. 2021-02-11T19:19:07Z 2021-02-11T19:19:07Z 2019-01-11 11:18:51 2019 book 29847 9783038974741 9783038974734 https://directory.doabooks.org/handle/20.500.12854/53211 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://www.mdpi.com/books/pdfview/book/1080 https://play.google.com/books/publish/a/14935057684283403269#details/ISBN:9783038974734 https://www.mdpi.com/books/pdfview/book/1080 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-474-1 10.3390/books978-3-03897-474-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038974741 9783038974734 204 open access |
| spellingShingle | QH301-705.5 RC254-282 NF2 signaling pathway tumor microenvironment mesothelioma experimental mesothelioma models thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Emanuela Felley-Bosco (Ed.) Mesothelioma Heterogeneity: Potential Mechanisms |
| title | Mesothelioma Heterogeneity: Potential Mechanisms |
| title_full | Mesothelioma Heterogeneity: Potential Mechanisms |
| title_fullStr | Mesothelioma Heterogeneity: Potential Mechanisms |
| title_full_unstemmed | Mesothelioma Heterogeneity: Potential Mechanisms |
| title_short | Mesothelioma Heterogeneity: Potential Mechanisms |
| title_sort | mesothelioma heterogeneity potential mechanisms |
| topic | QH301-705.5 RC254-282 NF2 signaling pathway tumor microenvironment mesothelioma experimental mesothelioma models thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 RC254-282 NF2 signaling pathway tumor microenvironment mesothelioma experimental mesothelioma models thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 29847 |
| work_keys_str_mv | AT emanuelafelleyboscoed mesotheliomaheterogeneitypotentialmechanisms |