Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent...
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| Główni autorzy: | , |
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| Format: | Online |
| Język: | angielski |
| Wydane: |
Frontiers Media SA
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | 31895 |
| Etykiety: |
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| _version_ | 1869519277319520256 |
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| author | Lluis Fajas Albert Giralt |
| author_browse | Albert Giralt Lluis Fajas |
| author_facet | Lluis Fajas Albert Giralt |
| author_sort | Lluis Fajas |
| collection | Directory of Open Access Books |
| description | Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer. |
| format | Online |
| id | doab-20.500.12854ir-53224 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-532242024-03-30T23:22:28Z Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions Lluis Fajas Albert Giralt R5-920 RC648-665 cancer metabolism proliferation mitochondria lipogenesis metabolic adaptation obesity Warburg effect thema EDItEUR::M Medicine and Nursing Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer. 2021-02-11T19:20:05Z 2021-02-11T19:20:05Z 2019-01-23 14:53:42 2018 book 31895 16648714 9782889454846 https://directory.doabooks.org/handle/20.500.12854/53224 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4124/metabolic-adaptation-to-cell-growth-and-proliferation-in-normal-and-pathological-conditions Frontiers Media SA 10.3389/978-2-88945-484-6 10.3389/978-2-88945-484-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454846 70 open access |
| spellingShingle | R5-920 RC648-665 cancer metabolism proliferation mitochondria lipogenesis metabolic adaptation obesity Warburg effect thema EDItEUR::M Medicine and Nursing Lluis Fajas Albert Giralt Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions |
| title | Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions |
| title_full | Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions |
| title_fullStr | Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions |
| title_full_unstemmed | Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions |
| title_short | Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions |
| title_sort | metabolic adaptation to cell growth and proliferation in normal and pathological conditions |
| topic | R5-920 RC648-665 cancer metabolism proliferation mitochondria lipogenesis metabolic adaptation obesity Warburg effect thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC648-665 cancer metabolism proliferation mitochondria lipogenesis metabolic adaptation obesity Warburg effect thema EDItEUR::M Medicine and Nursing |
| url | 31895 |
| work_keys_str_mv | AT lluisfajas metabolicadaptationtocellgrowthandproliferationinnormalandpathologicalconditions AT albertgiralt metabolicadaptationtocellgrowthandproliferationinnormalandpathologicalconditions |