The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration
Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic...
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| Format: | Online |
| Jezik: | angleščina |
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Frontiers Media SA
2021
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| Online dostop: | 25567 |
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| author | Enrique Cadenas Jia Yao Fei Yin Roberta Diaz Brinton |
| author_browse | Enrique Cadenas Fei Yin Jia Yao Roberta Diaz Brinton |
| author_facet | Enrique Cadenas Jia Yao Fei Yin Roberta Diaz Brinton |
| author_sort | Enrique Cadenas |
| collection | Directory of Open Access Books |
| description | Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function. |
| format | Online |
| id | doab-20.500.12854ir-53229 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-532292024-04-05T17:31:14Z The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration Enrique Cadenas Jia Yao Fei Yin Roberta Diaz Brinton RC321-571 Q1-390 Brain aging Mitochondria Energy Metabolism neurodegeneration Neuroinflammation Perimenopause redox homeostasis Alzheimer's disease diabetes thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function. 2021-02-11T19:21:54Z 2021-02-11T19:21:54Z 2018-02-27 16:16:44 2017 book 25567 16648714 9782889452538 https://directory.doabooks.org/handle/20.500.12854/53229 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_Metabolic-Inflammatory_Axis_in_Brain_Aging_and_Neurodegeneration/1291 http://journal.frontiersin.org/researchtopic/2807/the-metabolic-inflammatory-axis-in-brain-aging-and-neurodegeneration Frontiers Media SA 10.3389/978-2-88945-253-8 10.3389/978-2-88945-253-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452538 161 open access |
| spellingShingle | RC321-571 Q1-390 Brain aging Mitochondria Energy Metabolism neurodegeneration Neuroinflammation Perimenopause redox homeostasis Alzheimer's disease diabetes thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Enrique Cadenas Jia Yao Fei Yin Roberta Diaz Brinton The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration |
| title | The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration |
| title_full | The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration |
| title_fullStr | The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration |
| title_full_unstemmed | The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration |
| title_short | The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration |
| title_sort | metabolic inflammatory axis in brain aging and neurodegeneration |
| topic | RC321-571 Q1-390 Brain aging Mitochondria Energy Metabolism neurodegeneration Neuroinflammation Perimenopause redox homeostasis Alzheimer's disease diabetes thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Brain aging Mitochondria Energy Metabolism neurodegeneration Neuroinflammation Perimenopause redox homeostasis Alzheimer's disease diabetes thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 25567 |
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