Metabolomics in Neurodegenerative Disease
The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health servic...
محفوظ في:
| المؤلف الرئيسي: | |
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| التنسيق: | Online |
| اللغة: | الإنجليزية |
| منشور في: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | 46033 |
| الوسوم: |
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| _version_ | 1869525208580227072 |
|---|---|
| author | Green, Brian |
| author_browse | Green, Brian |
| author_facet | Green, Brian |
| author_sort | Green, Brian |
| collection | Directory of Open Access Books |
| description | The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health services. Tens of millions of people are indiscriminately affected by various dementias, which are rising at an alarming rate. There are no cures for many conditions, and it is clear that treatments applied as early as possible could greatly improve outcomes for patients. Therefore, new disease classification and diagnostic tools should be a key priority. Metabolomics represents a relatively new field of analytical science, which can be extremely useful in the early diagnosis of disease. The relatively unique feature of metabolites is that they sit at the intersection between the genetic background of an organism and its environment. Because many neurodegenerative diseases are not genetically inherited (instead having a range of known genetic risk factors and also a large number of unknown environmental triggers) the field of metabolomics offers great promise for the discovery of new, biologically, and clinically relevant biomarkers for neurodegenerative disorders. It is already bringing forward new knowledge in terms of the mechanisms of neurodegenerative disease. |
| format | Online |
| id | doab-20.500.12854ir-53236 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-532362024-04-05T12:33:08Z Metabolomics in Neurodegenerative Disease Green, Brian QH301-705.5 Q1-390 glutamic acid n/a direct mass spectrometry neurodegeneration 6-OHDA targeted mass spectrometry mitochondrial dysfunction myo-inositol metabolomics bile acids subacute mild traumatic brain injury age-related macular degeneration metabolic pathways energy metabolism midbrain Alzheimer’s disease biomarkers 1H NMR Parkinson’s disease dementia GC-MS pathogenesis tricarboxylic acid cycle micro-dialysis 13C-labeled succinate metabolism lipidomics dementia with Lewy bodies fatty acid prodromal Parkinson’s disease malonate cerebral ischemia mass spectrometry retinal pigment epithelium excitotoxicity endothelin-1 reperfusion C. elegans Streptomyces venezuelae ?-synuclein aggregates natural product fatty acid metabolism imaging mass spectrometry LC-MS drusen cerebral palsy plasma Parkinson’s disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health services. Tens of millions of people are indiscriminately affected by various dementias, which are rising at an alarming rate. There are no cures for many conditions, and it is clear that treatments applied as early as possible could greatly improve outcomes for patients. Therefore, new disease classification and diagnostic tools should be a key priority. Metabolomics represents a relatively new field of analytical science, which can be extremely useful in the early diagnosis of disease. The relatively unique feature of metabolites is that they sit at the intersection between the genetic background of an organism and its environment. Because many neurodegenerative diseases are not genetically inherited (instead having a range of known genetic risk factors and also a large number of unknown environmental triggers) the field of metabolomics offers great promise for the discovery of new, biologically, and clinically relevant biomarkers for neurodegenerative disorders. It is already bringing forward new knowledge in terms of the mechanisms of neurodegenerative disease. 2021-02-11T19:22:08Z 2021-02-11T19:22:08Z 2020-06-09 16:38:57 2020 book 46033 9783039280414 9783039280407 https://directory.doabooks.org/handle/20.500.12854/53236 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2226 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-041-4 10.3390/books978-3-03928-041-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039280414 9783039280407 184 open access |
| spellingShingle | QH301-705.5 Q1-390 glutamic acid n/a direct mass spectrometry neurodegeneration 6-OHDA targeted mass spectrometry mitochondrial dysfunction myo-inositol metabolomics bile acids subacute mild traumatic brain injury age-related macular degeneration metabolic pathways energy metabolism midbrain Alzheimer’s disease biomarkers 1H NMR Parkinson’s disease dementia GC-MS pathogenesis tricarboxylic acid cycle micro-dialysis 13C-labeled succinate metabolism lipidomics dementia with Lewy bodies fatty acid prodromal Parkinson’s disease malonate cerebral ischemia mass spectrometry retinal pigment epithelium excitotoxicity endothelin-1 reperfusion C. elegans Streptomyces venezuelae ?-synuclein aggregates natural product fatty acid metabolism imaging mass spectrometry LC-MS drusen cerebral palsy plasma Parkinson’s disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Green, Brian Metabolomics in Neurodegenerative Disease |
| title | Metabolomics in Neurodegenerative Disease |
| title_full | Metabolomics in Neurodegenerative Disease |
| title_fullStr | Metabolomics in Neurodegenerative Disease |
| title_full_unstemmed | Metabolomics in Neurodegenerative Disease |
| title_short | Metabolomics in Neurodegenerative Disease |
| title_sort | metabolomics in neurodegenerative disease |
| topic | QH301-705.5 Q1-390 glutamic acid n/a direct mass spectrometry neurodegeneration 6-OHDA targeted mass spectrometry mitochondrial dysfunction myo-inositol metabolomics bile acids subacute mild traumatic brain injury age-related macular degeneration metabolic pathways energy metabolism midbrain Alzheimer’s disease biomarkers 1H NMR Parkinson’s disease dementia GC-MS pathogenesis tricarboxylic acid cycle micro-dialysis 13C-labeled succinate metabolism lipidomics dementia with Lewy bodies fatty acid prodromal Parkinson’s disease malonate cerebral ischemia mass spectrometry retinal pigment epithelium excitotoxicity endothelin-1 reperfusion C. elegans Streptomyces venezuelae ?-synuclein aggregates natural product fatty acid metabolism imaging mass spectrometry LC-MS drusen cerebral palsy plasma Parkinson’s disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Q1-390 glutamic acid n/a direct mass spectrometry neurodegeneration 6-OHDA targeted mass spectrometry mitochondrial dysfunction myo-inositol metabolomics bile acids subacute mild traumatic brain injury age-related macular degeneration metabolic pathways energy metabolism midbrain Alzheimer’s disease biomarkers 1H NMR Parkinson’s disease dementia GC-MS pathogenesis tricarboxylic acid cycle micro-dialysis 13C-labeled succinate metabolism lipidomics dementia with Lewy bodies fatty acid prodromal Parkinson’s disease malonate cerebral ischemia mass spectrometry retinal pigment epithelium excitotoxicity endothelin-1 reperfusion C. elegans Streptomyces venezuelae ?-synuclein aggregates natural product fatty acid metabolism imaging mass spectrometry LC-MS drusen cerebral palsy plasma Parkinson’s disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 46033 |
| work_keys_str_mv | AT greenbrian metabolomicsinneurodegenerativedisease |