Metal economy in host-microbe interactions
From simple inorganic catalysts to vital biological cofactors, divalent transition metals are instrumental to electron transfers, catalysis and signaling. Their natural ability to bind, exchange and react with organic molecules including oxygen requires from living cells to regulate uptake with meta...
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| Main Authors: | , |
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| Format: | Online |
| Jezik: | angleščina |
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Frontiers Media SA
2021
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| Teme: | |
| Online dostop: | 17685 |
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| _version_ | 1869523951894396928 |
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| author | Frederic Veyrier Mathieu Cellier |
| author_browse | Frederic Veyrier Mathieu Cellier |
| author_facet | Frederic Veyrier Mathieu Cellier |
| author_sort | Frederic Veyrier |
| collection | Directory of Open Access Books |
| description | From simple inorganic catalysts to vital biological cofactors, divalent transition metals are instrumental to electron transfers, catalysis and signaling. Their natural ability to bind, exchange and react with organic molecules including oxygen requires from living cells to regulate uptake with metabolic activities, sensing and chaperoning, distributing and storing, or excreting excess to prevent detrimental biochemical reactions. Since transition metal deficiency and overload both limit cell growth it is no surprise that the immune system evolved a dual strategy, of metal starvation or intoxication, to thwart microbial invasions. Like environmental metal availability determined biological use it also shaped host-microbe metal economy: Fe and Mn, available early in evolution and still required rather ubiquitously, are generally withheld by host in response to infection; Zn and Cu, which became bioavailable later, essentially to eukaryotic cells may be bombarded toward invaders. Successful microbial pathogens have evolved elaborate counter-measures to cope with host metal defenses. This research topic aims to review and discuss metal currencies in host-microbe interactions focusing on new findings about micro-organism pathogenesis determinants in the face of host innate strategies to interfere with microbial physiology. |
| format | Online |
| id | doab-20.500.12854ir-53244 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-532442023-12-20T18:40:32Z Metal economy in host-microbe interactions Frederic Veyrier Mathieu Cellier Q1-390 RC109-216 exporter regulation Virulence transporter metal host pathogen bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general From simple inorganic catalysts to vital biological cofactors, divalent transition metals are instrumental to electron transfers, catalysis and signaling. Their natural ability to bind, exchange and react with organic molecules including oxygen requires from living cells to regulate uptake with metabolic activities, sensing and chaperoning, distributing and storing, or excreting excess to prevent detrimental biochemical reactions. Since transition metal deficiency and overload both limit cell growth it is no surprise that the immune system evolved a dual strategy, of metal starvation or intoxication, to thwart microbial invasions. Like environmental metal availability determined biological use it also shaped host-microbe metal economy: Fe and Mn, available early in evolution and still required rather ubiquitously, are generally withheld by host in response to infection; Zn and Cu, which became bioavailable later, essentially to eukaryotic cells may be bombarded toward invaders. Successful microbial pathogens have evolved elaborate counter-measures to cope with host metal defenses. This research topic aims to review and discuss metal currencies in host-microbe interactions focusing on new findings about micro-organism pathogenesis determinants in the face of host innate strategies to interfere with microbial physiology. 2021-02-11T19:22:23Z 2021-02-11T19:22:23Z 2015-11-16 15:44:59 2015 book 17685 16648714 9782889194971 https://directory.doabooks.org/handle/20.500.12854/53244 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Metal_economy_in_host-microbe_interactions/574 http://journal.frontiersin.org/researchtopic/1380/metal-economy-in-host-microbe-interactions Frontiers Media SA 10.3389/978-2-88919-497-1 10.3389/978-2-88919-497-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194971 215 open access |
| spellingShingle | Q1-390 RC109-216 exporter regulation Virulence transporter metal host pathogen bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general Frederic Veyrier Mathieu Cellier Metal economy in host-microbe interactions |
| title | Metal economy in host-microbe interactions |
| title_full | Metal economy in host-microbe interactions |
| title_fullStr | Metal economy in host-microbe interactions |
| title_full_unstemmed | Metal economy in host-microbe interactions |
| title_short | Metal economy in host-microbe interactions |
| title_sort | metal economy in host microbe interactions |
| topic | Q1-390 RC109-216 exporter regulation Virulence transporter metal host pathogen bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general |
| topic_facet | Q1-390 RC109-216 exporter regulation Virulence transporter metal host pathogen bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general |
| url | 17685 |
| work_keys_str_mv | AT fredericveyrier metaleconomyinhostmicrobeinteractions AT mathieucellier metaleconomyinhostmicrobeinteractions |