Metals and neurodegeneration: Restoring the balance
Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many a...
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| Ngā kaituhi matua: | , , |
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| Hōputu: | Online |
| Reo: | Ingarihi |
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Frontiers Media SA
2021
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| Ngā marau: | |
| Urunga tuihono: | 18859 |
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Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869522675901136896 |
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| author | Katja M. Kanninen Anthony R. White Peter J. Crouch |
| author_browse | Anthony R. White Katja M. Kanninen Peter J. Crouch |
| author_facet | Katja M. Kanninen Anthony R. White Peter J. Crouch |
| author_sort | Katja M. Kanninen |
| collection | Directory of Open Access Books |
| description | Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases. |
| format | Online |
| id | doab-20.500.12854ir-53258 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-532582024-04-05T12:36:26Z Metals and neurodegeneration: Restoring the balance Katja M. Kanninen Anthony R. White Peter J. Crouch RC321-571 Q1-390 Brain neurodegenerative disease Neurons Metals Iron Copper Alzheimer's disease Zinc Manganese thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases. 2021-02-11T19:22:53Z 2021-02-11T19:22:53Z 2016-04-07 11:22:02 2016 book 18859 16648714 9782889197392 https://directory.doabooks.org/handle/20.500.12854/53258 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Metals_and_Neurodegeneration_Restoring_the_Balance/791#nogo http://journal.frontiersin.org/researchtopic/820/metals-and-neurodegeneration-restoring-the-balance Frontiers Media SA 10.3389/978-2-88919-739-2 10.3389/978-2-88919-739-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197392 132 open access |
| spellingShingle | RC321-571 Q1-390 Brain neurodegenerative disease Neurons Metals Iron Copper Alzheimer's disease Zinc Manganese thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Katja M. Kanninen Anthony R. White Peter J. Crouch Metals and neurodegeneration: Restoring the balance |
| title | Metals and neurodegeneration: Restoring the balance |
| title_full | Metals and neurodegeneration: Restoring the balance |
| title_fullStr | Metals and neurodegeneration: Restoring the balance |
| title_full_unstemmed | Metals and neurodegeneration: Restoring the balance |
| title_short | Metals and neurodegeneration: Restoring the balance |
| title_sort | metals and neurodegeneration restoring the balance |
| topic | RC321-571 Q1-390 Brain neurodegenerative disease Neurons Metals Iron Copper Alzheimer's disease Zinc Manganese thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Brain neurodegenerative disease Neurons Metals Iron Copper Alzheimer's disease Zinc Manganese thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18859 |
| work_keys_str_mv | AT katjamkanninen metalsandneurodegenerationrestoringthebalance AT anthonyrwhite metalsandneurodegenerationrestoringthebalance AT peterjcrouch metalsandneurodegenerationrestoringthebalance |