Microbial Modulation of Host Apoptosis and Pyroptosis
Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a...
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| Format: | Online |
| Jezik: | angleščina |
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Frontiers Media SA
2021
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| Online dostop: | 17832 |
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| _version_ | 1869521942887792640 |
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| author | Amal O. Amer Yongqun He |
| author_browse | Amal O. Amer Yongqun He |
| author_facet | Amal O. Amer Yongqun He |
| author_sort | Amal O. Amer |
| collection | Directory of Open Access Books |
| description | Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis is an inflammatory cell death and is typically triggered by caspase-1 after its activation by various inflammasomes. However, some non-canonical caspase-1-independent proinflammatory cell death phenomena have been reported. Microbial pathogens are able to modulate host apoptosis and pyroptosis through different triggers and pathways. The promotion and inhibition of host apoptosis and pyroptosis vary and depend on the microbe types, virulence, and phenotypes. For example, virulent pathogens and attenuated vaccine strains may use different pathways to modulate host cell death. Specific microbial genes may be responsible for the modulation of host cell death. Different host cells, including macrophages, dendritic cells, and T cells, can undergo apoptosis and pyroptosis after microbial infections. The pathways of host apoptosis and pyroptosis induced by different microbes may also differ. Different methods can be used to study the interaction between microbes and host cell death system. The articles included in this E-book report the cutting edge findings in the areas of microbial modulation of host apoptosis, pyroptosis and inflammasome. |
| format | Online |
| id | doab-20.500.12854ir-53402 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-534022023-12-20T18:40:32Z Microbial Modulation of Host Apoptosis and Pyroptosis Amal O. Amer Yongqun He Q1-390 RC109-216 microbial infection pyroptosis Mycobacterium tuberculosis bacterial exploitation of apoptosis Brucella Infectious Disease Inflammasome Legionella programmed cell death Apoptosis bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis is an inflammatory cell death and is typically triggered by caspase-1 after its activation by various inflammasomes. However, some non-canonical caspase-1-independent proinflammatory cell death phenomena have been reported. Microbial pathogens are able to modulate host apoptosis and pyroptosis through different triggers and pathways. The promotion and inhibition of host apoptosis and pyroptosis vary and depend on the microbe types, virulence, and phenotypes. For example, virulent pathogens and attenuated vaccine strains may use different pathways to modulate host cell death. Specific microbial genes may be responsible for the modulation of host cell death. Different host cells, including macrophages, dendritic cells, and T cells, can undergo apoptosis and pyroptosis after microbial infections. The pathways of host apoptosis and pyroptosis induced by different microbes may also differ. Different methods can be used to study the interaction between microbes and host cell death system. The articles included in this E-book report the cutting edge findings in the areas of microbial modulation of host apoptosis, pyroptosis and inflammasome. 2021-02-11T19:32:26Z 2021-02-11T19:32:26Z 2015-12-10 11:59:06 2014 book 17832 16648714 9782889192809 https://directory.doabooks.org/handle/20.500.12854/53402 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Microbial_Modulation_of_Host_Apoptosis_and_Pyroptosis/332#nogo http://journal.frontiersin.org/researchtopic/1309/microbial-modulation-of-host-apoptosis-and-pyroptosis Frontiers Media SA 10.3389/978-2-88919-280-9 10.3389/978-2-88919-280-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889192809 109 open access |
| spellingShingle | Q1-390 RC109-216 microbial infection pyroptosis Mycobacterium tuberculosis bacterial exploitation of apoptosis Brucella Infectious Disease Inflammasome Legionella programmed cell death Apoptosis bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general Amal O. Amer Yongqun He Microbial Modulation of Host Apoptosis and Pyroptosis |
| title | Microbial Modulation of Host Apoptosis and Pyroptosis |
| title_full | Microbial Modulation of Host Apoptosis and Pyroptosis |
| title_fullStr | Microbial Modulation of Host Apoptosis and Pyroptosis |
| title_full_unstemmed | Microbial Modulation of Host Apoptosis and Pyroptosis |
| title_short | Microbial Modulation of Host Apoptosis and Pyroptosis |
| title_sort | microbial modulation of host apoptosis and pyroptosis |
| topic | Q1-390 RC109-216 microbial infection pyroptosis Mycobacterium tuberculosis bacterial exploitation of apoptosis Brucella Infectious Disease Inflammasome Legionella programmed cell death Apoptosis bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general |
| topic_facet | Q1-390 RC109-216 microbial infection pyroptosis Mycobacterium tuberculosis bacterial exploitation of apoptosis Brucella Infectious Disease Inflammasome Legionella programmed cell death Apoptosis bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general |
| url | 17832 |
| work_keys_str_mv | AT amaloamer microbialmodulationofhostapoptosisandpyroptosis AT yongqunhe microbialmodulationofhostapoptosisandpyroptosis |