Microglia in Health and Disease: A Unique Immune Cell Population
Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The un...
Sábháilte in:
| Príomhchruthaitheoirí: | , , |
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| Formáid: | Online |
| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
Frontiers Media SA
2021
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| Ábhair: | |
| Rochtain ar líne: | 32000 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| _version_ | 1869515073238597632 |
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| author | Michel Mittelbronn Diego Gomez-Nicola Alessandro Michelucci |
| author_browse | Alessandro Michelucci Diego Gomez-Nicola Michel Mittelbronn |
| author_facet | Michel Mittelbronn Diego Gomez-Nicola Alessandro Michelucci |
| author_sort | Michel Mittelbronn |
| collection | Directory of Open Access Books |
| description | Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes. |
| format | Online |
| id | doab-20.500.12854ir-53424 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-534242024-03-30T23:21:42Z Microglia in Health and Disease: A Unique Immune Cell Population Michel Mittelbronn Diego Gomez-Nicola Alessandro Michelucci R5-920 RC346-429 RC581-607 inflammation brain tumour neurodegeneration microglia ontogeny thema EDItEUR::M Medicine and Nursing Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes. 2021-02-11T19:33:55Z 2021-02-11T19:33:55Z 2019-01-23 14:53:43 2018 book 32000 16648714 9782889456017 https://directory.doabooks.org/handle/20.500.12854/53424 eng Frontiers Research Topics image/png Attribution 4.0 International https://www.frontiersin.org/research-topics/6533/microglia-in-health-and-disease-a-unique-immune-cell-population Frontiers Media SA 10.3389/978-2-88945-601-7 10.3389/978-2-88945-601-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456017 108 open access |
| spellingShingle | R5-920 RC346-429 RC581-607 inflammation brain tumour neurodegeneration microglia ontogeny thema EDItEUR::M Medicine and Nursing Michel Mittelbronn Diego Gomez-Nicola Alessandro Michelucci Microglia in Health and Disease: A Unique Immune Cell Population |
| title | Microglia in Health and Disease: A Unique Immune Cell Population |
| title_full | Microglia in Health and Disease: A Unique Immune Cell Population |
| title_fullStr | Microglia in Health and Disease: A Unique Immune Cell Population |
| title_full_unstemmed | Microglia in Health and Disease: A Unique Immune Cell Population |
| title_short | Microglia in Health and Disease: A Unique Immune Cell Population |
| title_sort | microglia in health and disease a unique immune cell population |
| topic | R5-920 RC346-429 RC581-607 inflammation brain tumour neurodegeneration microglia ontogeny thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC346-429 RC581-607 inflammation brain tumour neurodegeneration microglia ontogeny thema EDItEUR::M Medicine and Nursing |
| url | 32000 |
| work_keys_str_mv | AT michelmittelbronn microgliainhealthanddiseaseauniqueimmunecellpopulation AT diegogomeznicola microgliainhealthanddiseaseauniqueimmunecellpopulation AT alessandromichelucci microgliainhealthanddiseaseauniqueimmunecellpopulation |