Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflamma...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media SA
2021
|
| Subjects: | |
| Online Access: | 31935 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1869519538350981120 |
|---|---|
| author | Isidre Ferrer Yu Tang |
| author_browse | Isidre Ferrer Yu Tang |
| author_facet | Isidre Ferrer Yu Tang |
| author_sort | Isidre Ferrer |
| collection | Directory of Open Access Books |
| description | Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization. |
| format | Online |
| id | doab-20.500.12854ir-53425 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-534252024-04-05T12:35:58Z Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases Isidre Ferrer Yu Tang RC321-571 Q1-390 M2 Microglia Microglial Polarization Neurodegenerative diseases M1 Microglia Aging Neuroinflammation M1/M2 Switch thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization. 2021-02-11T19:33:59Z 2021-02-11T19:33:59Z 2019-01-23 14:53:42 2018 book 31935 16648714 9782889455256 https://directory.doabooks.org/handle/20.500.12854/53425 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4822/microglial-polarization-in-the-pathogenesis-and-therapeutics-of-neurodegenerative-diseases Frontiers Media SA 10.3389/978-2-88945-525-6 10.3389/978-2-88945-525-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455256 327 open access |
| spellingShingle | RC321-571 Q1-390 M2 Microglia Microglial Polarization Neurodegenerative diseases M1 Microglia Aging Neuroinflammation M1/M2 Switch thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Isidre Ferrer Yu Tang Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases |
| title | Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases |
| title_full | Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases |
| title_fullStr | Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases |
| title_full_unstemmed | Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases |
| title_short | Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases |
| title_sort | microglial polarization in the pathogenesis and therapeutics of neurodegenerative diseases |
| topic | RC321-571 Q1-390 M2 Microglia Microglial Polarization Neurodegenerative diseases M1 Microglia Aging Neuroinflammation M1/M2 Switch thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 M2 Microglia Microglial Polarization Neurodegenerative diseases M1 Microglia Aging Neuroinflammation M1/M2 Switch thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 31935 |
| work_keys_str_mv | AT isidreferrer microglialpolarizationinthepathogenesisandtherapeuticsofneurodegenerativediseases AT yutang microglialpolarizationinthepathogenesisandtherapeuticsofneurodegenerativediseases |