MicroRNA as Biomarkers in Cancer Diagnostics and Therapy
This Special Issue celebrates the 25th anniversary of the discovery of the first microRNA. The size of the microRNome and complexity of animal body plans and organ systems suggests a role for microRNAs in cell fate determination and differentiation. More than 2000 sequences have been proposed to rep...
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| Главный автор: | |
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| Формат: | Online |
| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Предметы: | |
| Online-ссылка: | 35937 |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
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| _version_ | 1869523746436415488 |
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| author | Sempere, Lorenzo F. |
| author_browse | Sempere, Lorenzo F. |
| author_facet | Sempere, Lorenzo F. |
| author_sort | Sempere, Lorenzo F. |
| collection | Directory of Open Access Books |
| description | This Special Issue celebrates the 25th anniversary of the discovery of the first microRNA. The size of the microRNome and complexity of animal body plans and organ systems suggests a role for microRNAs in cell fate determination and differentiation. More than 2000 sequences have been proposed to represent unique microRNA genes in humans, with an increasing number of mechanistic roles identified in developmental, physiological, and pathological processes. Thus, dysregulation of a few key microRNAs can have a profound global effect on the gene expression and molecular programs of a cell. This great potential for clinical intervention has captured the interest and imagination of researchers in many fields. However, very few fields have been as prolific as the field of cancer research. This Special Issue provides but a glimpse of the large body of literature of microRNA biology in cancer research, containing 4 original research studies and 4 review articles that focus on specific hematologic or solid tumors in disease. Collectively, these articles highlight state-of-the-art approaches and methodologies for microRNA detection in tissue, blood, and other body fluids in a range of biomarkers applications, from early cancer detection to prognosis and treatment response. The articles also address some of the challenges regarding clinical implementation. |
| format | Online |
| id | doab-20.500.12854ir-53436 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-534362024-04-05T12:32:55Z MicroRNA as Biomarkers in Cancer Diagnostics and Therapy Sempere, Lorenzo F. QH301-705.5 QR1-502 Q1-390 leukemia n/a cell lines hepatitis B virus long non coding RNA normalization of miRNA expression in RT-qPCR children colorectal review bevacizumab tumor budding cells oral cancer liquid biopsy hepatocellular carcinoma small t-antigen colorectal cancer protein-miRNA complex biomarkers biomarker interleukin-1? tissue analysis miRNAs T-cell acute lymphoblastic leukemia (T-ALL) leukoplakia inflammation exosomes circulating free DNA hepatitis C virus miRNA miR-21 extracellular microRNA endogenous controls lymphoma confocal slide scanning microscopy early diagnosis reference genes large T-antigen microRNA miRNA (microRNA) cancer TNF-? plasma thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Special Issue celebrates the 25th anniversary of the discovery of the first microRNA. The size of the microRNome and complexity of animal body plans and organ systems suggests a role for microRNAs in cell fate determination and differentiation. More than 2000 sequences have been proposed to represent unique microRNA genes in humans, with an increasing number of mechanistic roles identified in developmental, physiological, and pathological processes. Thus, dysregulation of a few key microRNAs can have a profound global effect on the gene expression and molecular programs of a cell. This great potential for clinical intervention has captured the interest and imagination of researchers in many fields. However, very few fields have been as prolific as the field of cancer research. This Special Issue provides but a glimpse of the large body of literature of microRNA biology in cancer research, containing 4 original research studies and 4 review articles that focus on specific hematologic or solid tumors in disease. Collectively, these articles highlight state-of-the-art approaches and methodologies for microRNA detection in tissue, blood, and other body fluids in a range of biomarkers applications, from early cancer detection to prognosis and treatment response. The articles also address some of the challenges regarding clinical implementation. 2021-02-11T19:35:52Z 2021-02-11T19:35:52Z 2019-08-28 11:21:27 2019 book 35937 9783039212491 9783039212507 https://directory.doabooks.org/handle/20.500.12854/53436 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1461 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-250-7 10.3390/books978-3-03921-250-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039212491 9783039212507 166 open access |
| spellingShingle | QH301-705.5 QR1-502 Q1-390 leukemia n/a cell lines hepatitis B virus long non coding RNA normalization of miRNA expression in RT-qPCR children colorectal review bevacizumab tumor budding cells oral cancer liquid biopsy hepatocellular carcinoma small t-antigen colorectal cancer protein-miRNA complex biomarkers biomarker interleukin-1? tissue analysis miRNAs T-cell acute lymphoblastic leukemia (T-ALL) leukoplakia inflammation exosomes circulating free DNA hepatitis C virus miRNA miR-21 extracellular microRNA endogenous controls lymphoma confocal slide scanning microscopy early diagnosis reference genes large T-antigen microRNA miRNA (microRNA) cancer TNF-? plasma thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Sempere, Lorenzo F. MicroRNA as Biomarkers in Cancer Diagnostics and Therapy |
| title | MicroRNA as Biomarkers in Cancer Diagnostics and Therapy |
| title_full | MicroRNA as Biomarkers in Cancer Diagnostics and Therapy |
| title_fullStr | MicroRNA as Biomarkers in Cancer Diagnostics and Therapy |
| title_full_unstemmed | MicroRNA as Biomarkers in Cancer Diagnostics and Therapy |
| title_short | MicroRNA as Biomarkers in Cancer Diagnostics and Therapy |
| title_sort | microrna as biomarkers in cancer diagnostics and therapy |
| topic | QH301-705.5 QR1-502 Q1-390 leukemia n/a cell lines hepatitis B virus long non coding RNA normalization of miRNA expression in RT-qPCR children colorectal review bevacizumab tumor budding cells oral cancer liquid biopsy hepatocellular carcinoma small t-antigen colorectal cancer protein-miRNA complex biomarkers biomarker interleukin-1? tissue analysis miRNAs T-cell acute lymphoblastic leukemia (T-ALL) leukoplakia inflammation exosomes circulating free DNA hepatitis C virus miRNA miR-21 extracellular microRNA endogenous controls lymphoma confocal slide scanning microscopy early diagnosis reference genes large T-antigen microRNA miRNA (microRNA) cancer TNF-? plasma thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 QR1-502 Q1-390 leukemia n/a cell lines hepatitis B virus long non coding RNA normalization of miRNA expression in RT-qPCR children colorectal review bevacizumab tumor budding cells oral cancer liquid biopsy hepatocellular carcinoma small t-antigen colorectal cancer protein-miRNA complex biomarkers biomarker interleukin-1? tissue analysis miRNAs T-cell acute lymphoblastic leukemia (T-ALL) leukoplakia inflammation exosomes circulating free DNA hepatitis C virus miRNA miR-21 extracellular microRNA endogenous controls lymphoma confocal slide scanning microscopy early diagnosis reference genes large T-antigen microRNA miRNA (microRNA) cancer TNF-? plasma thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 35937 |
| work_keys_str_mv | AT semperelorenzof micrornaasbiomarkersincancerdiagnosticsandtherapy |