MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers
MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostas...
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| Váldodahkkit: | , |
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| Materiálatiipa: | Online |
| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Fáttát: | |
| Liŋkkat: | 29130 |
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| _version_ | 1869521733937004544 |
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| author | Ryou-u Takahashi (Ed.) Takahiro Ochiya (Ed.) |
| author_browse | Ryou-u Takahashi (Ed.) Takahiro Ochiya (Ed.) |
| author_facet | Ryou-u Takahashi (Ed.) Takahiro Ochiya (Ed.) |
| author_sort | Ryou-u Takahashi (Ed.) |
| collection | Directory of Open Access Books |
| description | MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are involved in the onset of many diseases, including cancer. In various types of cancer, miRNAs play important roles in tumor initiation and development. Recently, miRNAs have been demonstrated to also be secreted via small endosome-derived vesicles called exosomes—which are derived from multiple cell types—including immunocytes and cancer cells. Exosomal miRNAs exert important functions in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers. |
| format | Online |
| id | doab-20.500.12854ir-53438 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-534382024-03-30T23:22:55Z MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers Ryou-u Takahashi (Ed.) Takahiro Ochiya (Ed.) R5-920 RM1-950 RC254-282 tumor initiation and development cancer therapy circulating microRNA microRNA diagnosis biomarker exosome thema EDItEUR::M Medicine and Nursing MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are involved in the onset of many diseases, including cancer. In various types of cancer, miRNAs play important roles in tumor initiation and development. Recently, miRNAs have been demonstrated to also be secreted via small endosome-derived vesicles called exosomes—which are derived from multiple cell types—including immunocytes and cancer cells. Exosomal miRNAs exert important functions in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers. 2021-02-11T19:35:56Z 2021-02-11T19:35:56Z 2018-10-16 10:23:45 2018 book 29130 9783038972525 9783038972532 https://directory.doabooks.org/handle/20.500.12854/53438 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://play.google.com/books/publish/a/14935057684283403269#details/ISBN:9783038972525 https://www.mdpi.com/books/pdfview/book/800 https://www.mdpi.com/books/pdfview/book/800 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-253-2 10.3390/books978-3-03897-253-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038972525 9783038972532 272 open access |
| spellingShingle | R5-920 RM1-950 RC254-282 tumor initiation and development cancer therapy circulating microRNA microRNA diagnosis biomarker exosome thema EDItEUR::M Medicine and Nursing Ryou-u Takahashi (Ed.) Takahiro Ochiya (Ed.) MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers |
| title | MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers |
| title_full | MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers |
| title_fullStr | MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers |
| title_full_unstemmed | MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers |
| title_short | MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers |
| title_sort | micrornas novel biomarkers and therapeutic targets for human cancers |
| topic | R5-920 RM1-950 RC254-282 tumor initiation and development cancer therapy circulating microRNA microRNA diagnosis biomarker exosome thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RM1-950 RC254-282 tumor initiation and development cancer therapy circulating microRNA microRNA diagnosis biomarker exosome thema EDItEUR::M Medicine and Nursing |
| url | 29130 |
| work_keys_str_mv | AT ryouutakahashied micrornasnovelbiomarkersandtherapeutictargetsforhumancancers AT takahiroochiyaed micrornasnovelbiomarkersandtherapeutictargetsforhumancancers |