Modeling and Analysis of Signal Transduction Networks
Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential drug targets. Elucidating the dynamic behavior of...
Đã lưu trong:
| Định dạng: | Online |
|---|---|
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Những chủ đề: | |
| Truy cập trực tuyến: | 19033 |
| Các nhãn: |
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| _version_ | 1869528499447922688 |
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| collection | Directory of Open Access Books |
| description | Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential drug targets. Elucidating the dynamic behavior of the components of pathways, and their interactions, is one of the key research areas of systems biology. Biological signaling networks are characterized by a large number of components and an even larger number of parameters describing the network. Furthermore, investigations of signaling networks are characterized by large uncertainties of the network as well as limited availability of data due to expensive and time-consuming experiments. As such, techniques derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter estimation, are important tools for elucidating the mechanisms involved in signaling networks. This Special Issue contains papers that investigate a variety of different signaling networks via established, as well as newly developed modeling and analysis techniques. |
| format | Online |
| id | doab-20.500.12854ir-53680 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-536802022-01-31T18:49:42Z Modeling and Analysis of Signal Transduction Networks modeling signal transduction sensitivity analysis cross-talk parameter estimation experimental design Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential drug targets. Elucidating the dynamic behavior of the components of pathways, and their interactions, is one of the key research areas of systems biology. Biological signaling networks are characterized by a large number of components and an even larger number of parameters describing the network. Furthermore, investigations of signaling networks are characterized by large uncertainties of the network as well as limited availability of data due to expensive and time-consuming experiments. As such, techniques derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter estimation, are important tools for elucidating the mechanisms involved in signaling networks. This Special Issue contains papers that investigate a variety of different signaling networks via established, as well as newly developed modeling and analysis techniques. 2021-02-11T19:53:31Z 2021-02-11T19:53:31Z 2016-05-12 12:19:39 2016 book 19033 9783038421429 9783038421412 https://directory.doabooks.org/handle/20.500.12854/53680 eng application/octet-stream Attribution 4.0 International http://amzn.to/1TQY0IY http://www.mdpi.com/books/pdfview/book/186 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038421429 9783038421412 232 open access |
| spellingShingle | modeling signal transduction sensitivity analysis cross-talk parameter estimation experimental design Modeling and Analysis of Signal Transduction Networks |
| title | Modeling and Analysis of Signal Transduction Networks |
| title_full | Modeling and Analysis of Signal Transduction Networks |
| title_fullStr | Modeling and Analysis of Signal Transduction Networks |
| title_full_unstemmed | Modeling and Analysis of Signal Transduction Networks |
| title_short | Modeling and Analysis of Signal Transduction Networks |
| title_sort | modeling and analysis of signal transduction networks |
| topic | modeling signal transduction sensitivity analysis cross-talk parameter estimation experimental design |
| topic_facet | modeling signal transduction sensitivity analysis cross-talk parameter estimation experimental design |
| url | 19033 |