Molecular mechanisms for reprogramming hippocampal development and function by early-life stress
The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in...
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| Format: | Online |
| Jezik: | angleščina |
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Frontiers Media SA
2021
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| Online dostop: | 18914 |
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| _version_ | 1869525696677675008 |
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| author | Mathias V. Schmidt Xiao-Dong Wang |
| author_browse | Mathias V. Schmidt Xiao-Dong Wang |
| author_facet | Mathias V. Schmidt Xiao-Dong Wang |
| author_sort | Mathias V. Schmidt |
| collection | Directory of Open Access Books |
| description | The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in life have profound and persistent effects on hippocampal function and behavior. This research topic focuses on the acute and lasting effects of early-life stress on various developmental processes in the hippocampus, and aims to uncover the molecules that are responsible for early-life stress-programmed effects and underlie resilience or vulnerability to stress-related neuropsychiatric disorders later in life. We hope the articles in this research topic will provide novel insights and stimulate future studies on the mechanisms of early-life stress and brain development. |
| format | Online |
| id | doab-20.500.12854ir-53848 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-538482024-04-05T17:31:05Z Molecular mechanisms for reprogramming hippocampal development and function by early-life stress Mathias V. Schmidt Xiao-Dong Wang RC321-571 Q1-390 development molecular mechanism early-life stress plasticity Hippocampus psychiatric disorders thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in life have profound and persistent effects on hippocampal function and behavior. This research topic focuses on the acute and lasting effects of early-life stress on various developmental processes in the hippocampus, and aims to uncover the molecules that are responsible for early-life stress-programmed effects and underlie resilience or vulnerability to stress-related neuropsychiatric disorders later in life. We hope the articles in this research topic will provide novel insights and stimulate future studies on the mechanisms of early-life stress and brain development. 2021-02-11T20:04:59Z 2021-02-11T20:04:59Z 2016-04-07 11:22:02 2016 book 18914 16648714 9782889198061 https://directory.doabooks.org/handle/20.500.12854/53848 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Molecular_Mechanisms_for_Reprogramming_Hippocampal_Development_and_Function_by_Early-Life_Stress/838 http://journal.frontiersin.org/researchtopic/1935/molecular-mechanisms-for-reprogramming-hippocampal-development-and-function-by-early-life-stress Frontiers Media SA 10.3389/978-2-88919-806-1 10.3389/978-2-88919-806-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198061 100 open access |
| spellingShingle | RC321-571 Q1-390 development molecular mechanism early-life stress plasticity Hippocampus psychiatric disorders thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Mathias V. Schmidt Xiao-Dong Wang Molecular mechanisms for reprogramming hippocampal development and function by early-life stress |
| title | Molecular mechanisms for reprogramming hippocampal development and function by early-life stress |
| title_full | Molecular mechanisms for reprogramming hippocampal development and function by early-life stress |
| title_fullStr | Molecular mechanisms for reprogramming hippocampal development and function by early-life stress |
| title_full_unstemmed | Molecular mechanisms for reprogramming hippocampal development and function by early-life stress |
| title_short | Molecular mechanisms for reprogramming hippocampal development and function by early-life stress |
| title_sort | molecular mechanisms for reprogramming hippocampal development and function by early life stress |
| topic | RC321-571 Q1-390 development molecular mechanism early-life stress plasticity Hippocampus psychiatric disorders thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 development molecular mechanism early-life stress plasticity Hippocampus psychiatric disorders thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18914 |
| work_keys_str_mv | AT mathiasvschmidt molecularmechanismsforreprogramminghippocampaldevelopmentandfunctionbyearlylifestress AT xiaodongwang molecularmechanismsforreprogramminghippocampaldevelopmentandfunctionbyearlylifestress |