Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or...
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| Автори: | , |
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| Формат: | Online |
| Мова: | Англійська |
| Опубліковано: |
Frontiers Media SA
2021
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| Предмети: | |
| Онлайн доступ: | 17684 |
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| _version_ | 1869526493446537216 |
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| author | Megan Chircop Daniel Speidel |
| author_browse | Daniel Speidel Megan Chircop |
| author_facet | Megan Chircop Daniel Speidel |
| author_sort | Megan Chircop |
| collection | Directory of Open Access Books |
| description | In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required.This Research topic aims to reflect the broadness and complexity of this important area of cancer research. |
| format | Online |
| id | doab-20.500.12854ir-53849 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-538492024-03-31T13:09:46Z Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications Megan Chircop Daniel Speidel R5-920 RC254-282 DNA Repair DNA Damage tumorigenesis therapeutic targets chemotherapy Apoptosis cellular stress therapy resistance thema EDItEUR::M Medicine and Nursing In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required.This Research topic aims to reflect the broadness and complexity of this important area of cancer research. 2021-02-11T20:05:01Z 2021-02-11T20:05:01Z 2015-11-16 15:44:59 2015 book 17684 16648714 9782889194964 https://directory.doabooks.org/handle/20.500.12854/53849 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Molecular_mechanisms_of_cellular_stress_responses_in_cancer_and_their_therapeutic_implications/461#nogo http://journal.frontiersin.org/researchtopic/1922/molecular-mechanisms-of-cellular-stress-responses-in-cancer-and-their-therapeutic-implications Frontiers Media SA 10.3389/978-2-88919-496-4 10.3389/978-2-88919-496-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194964 159 open access |
| spellingShingle | R5-920 RC254-282 DNA Repair DNA Damage tumorigenesis therapeutic targets chemotherapy Apoptosis cellular stress therapy resistance thema EDItEUR::M Medicine and Nursing Megan Chircop Daniel Speidel Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications |
| title | Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications |
| title_full | Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications |
| title_fullStr | Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications |
| title_full_unstemmed | Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications |
| title_short | Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications |
| title_sort | molecular mechanisms of cellular stress responses in cancer and their therapeutic implications |
| topic | R5-920 RC254-282 DNA Repair DNA Damage tumorigenesis therapeutic targets chemotherapy Apoptosis cellular stress therapy resistance thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 DNA Repair DNA Damage tumorigenesis therapeutic targets chemotherapy Apoptosis cellular stress therapy resistance thema EDItEUR::M Medicine and Nursing |
| url | 17684 |
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