Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases

Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and che...

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Bibliographic Details

Main Authors:	Konrad Krzewski, Yenan Bryceson
Format:	Online
Language:	English
Published:	Frontiers Media SA 2021
Subjects:	R5-920 RC581-607 secretory lysosomes NK cells hemophagocytic histiocytosis immune therapy granzyme lytic granules Cytotoxicity anti-tumor response Immunological Synapse Perforin thema EDItEUR::M Medicine and Nursing
Online Access:	17831
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