Molecular Nanomachines of the Presynaptic Terminal
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological...
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| المؤلفون الرئيسيون: | , |
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| التنسيق: | Online |
| اللغة: | الإنجليزية |
| منشور في: |
Frontiers Media SA
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | 18385 |
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| _version_ | 1869517187731947520 |
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| author | Lucia Tabares Silvio O. Rizzoli |
| author_browse | Lucia Tabares Silvio O. Rizzoli |
| author_facet | Lucia Tabares Silvio O. Rizzoli |
| author_sort | Lucia Tabares |
| collection | Directory of Open Access Books |
| description | Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling. |
| format | Online |
| id | doab-20.500.12854ir-53852 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-538522024-04-05T12:35:46Z Molecular Nanomachines of the Presynaptic Terminal Lucia Tabares Silvio O. Rizzoli RC321-571 Q1-390 synaptic protein active Zone nanomachine synapse synaptic vesicle thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling. 2021-02-11T20:05:08Z 2021-02-11T20:05:08Z 2016-01-19 14:05:46 2016 book 18385 16648714 9782889199983 https://directory.doabooks.org/handle/20.500.12854/53852 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Molecular_Nanomachines_of_the_Presynaptic_Terminal/1030 http://journal.frontiersin.org/researchtopic/3643/molecular-nanomachines-of-the-presynaptic-terminal Frontiers Media SA 10.3389/978-2-88919-998-3 10.3389/978-2-88919-998-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199983 110 open access |
| spellingShingle | RC321-571 Q1-390 synaptic protein active Zone nanomachine synapse synaptic vesicle thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Lucia Tabares Silvio O. Rizzoli Molecular Nanomachines of the Presynaptic Terminal |
| title | Molecular Nanomachines of the Presynaptic Terminal |
| title_full | Molecular Nanomachines of the Presynaptic Terminal |
| title_fullStr | Molecular Nanomachines of the Presynaptic Terminal |
| title_full_unstemmed | Molecular Nanomachines of the Presynaptic Terminal |
| title_short | Molecular Nanomachines of the Presynaptic Terminal |
| title_sort | molecular nanomachines of the presynaptic terminal |
| topic | RC321-571 Q1-390 synaptic protein active Zone nanomachine synapse synaptic vesicle thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 synaptic protein active Zone nanomachine synapse synaptic vesicle thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18385 |
| work_keys_str_mv | AT luciatabares molecularnanomachinesofthepresynapticterminal AT silvioorizzoli molecularnanomachinesofthepresynapticterminal |