The molecular pathology of cognitive decline: Focus on metals
In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attenti...
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| Format: | Online |
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Frontiers Media SA
2021
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| Online Access: | 18840 |
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| _version_ | 1869515044963745792 |
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| author | Roger Chung Paul A. Adlard |
| author_browse | Paul A. Adlard Roger Chung |
| author_facet | Roger Chung Paul A. Adlard |
| author_sort | Roger Chung |
| collection | Directory of Open Access Books |
| description | In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics. |
| format | Online |
| id | doab-20.500.12854ir-53855 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-538552024-04-05T12:35:28Z The molecular pathology of cognitive decline: Focus on metals Roger Chung Paul A. Adlard RC321-571 Q1-390 Down Syndrome Amyotrophic Lateral Sclerosis Parkinson's disease aluminium Iron TBI Cognition Copper Alzheimer's disease Zinc thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics. 2021-02-11T20:05:14Z 2021-02-11T20:05:14Z 2016-04-07 11:22:02 2016 book 18840 16648714 9782889197200 https://directory.doabooks.org/handle/20.500.12854/53855 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_Molecular_Pathology_of_Cognitive_Decline_Focus_on_Metals/790#nogo http://journal.frontiersin.org/researchtopic/1341/the-molecular-pathology-of-cognitive-decline-focus-on-metals Frontiers Media SA 10.3389/978-2-88919-720-0 10.3389/978-2-88919-720-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197200 175 open access |
| spellingShingle | RC321-571 Q1-390 Down Syndrome Amyotrophic Lateral Sclerosis Parkinson's disease aluminium Iron TBI Cognition Copper Alzheimer's disease Zinc thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Roger Chung Paul A. Adlard The molecular pathology of cognitive decline: Focus on metals |
| title | The molecular pathology of cognitive decline: Focus on metals |
| title_full | The molecular pathology of cognitive decline: Focus on metals |
| title_fullStr | The molecular pathology of cognitive decline: Focus on metals |
| title_full_unstemmed | The molecular pathology of cognitive decline: Focus on metals |
| title_short | The molecular pathology of cognitive decline: Focus on metals |
| title_sort | molecular pathology of cognitive decline focus on metals |
| topic | RC321-571 Q1-390 Down Syndrome Amyotrophic Lateral Sclerosis Parkinson's disease aluminium Iron TBI Cognition Copper Alzheimer's disease Zinc thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Down Syndrome Amyotrophic Lateral Sclerosis Parkinson's disease aluminium Iron TBI Cognition Copper Alzheimer's disease Zinc thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18840 |
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