Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease
The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to unders...
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| Formaat: | Online |
| Taal: | Engels |
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Frontiers Media SA
2021
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| Online toegang: | 23478 |
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| _version_ | 1869515538288345088 |
|---|---|
| author | Robert J. Harvey Kirsten Harvey |
| author_browse | Kirsten Harvey Robert J. Harvey |
| author_facet | Robert J. Harvey Kirsten Harvey |
| author_sort | Robert J. Harvey |
| collection | Directory of Open Access Books |
| description | The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants. |
| format | Online |
| id | doab-20.500.12854ir-53863 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-538632024-04-05T12:35:32Z Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease Robert J. Harvey Kirsten Harvey RC321-571 Q1-390 Stem Cells glycine receptor Amyotrophic Lateral Sclerosis Parkinson's disease PET imaging LRRK2 Zebrafish Inflammation GABA-A receptor NMDA receptors Intellectual Disability thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants. 2021-02-11T20:05:33Z 2021-02-11T20:05:33Z 2017-08-28 14:01:09 2017 book 23478 16648714 9782889451739 https://directory.doabooks.org/handle/20.500.12854/53863 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Molecular_Cellular_and_Model_Organism_Approaches_for_Understanding_the_Basis_of_Neurological_Diseas/1235#nogo http://journal.frontiersin.org/researchtopic/4437/molecular-cellular-and-model-organism-approaches-for-understanding-the-basis-of-neurological-disease Frontiers Media SA 10.3389/978-2-88945-173-9 10.3389/978-2-88945-173-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889451739 183 open access |
| spellingShingle | RC321-571 Q1-390 Stem Cells glycine receptor Amyotrophic Lateral Sclerosis Parkinson's disease PET imaging LRRK2 Zebrafish Inflammation GABA-A receptor NMDA receptors Intellectual Disability thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Robert J. Harvey Kirsten Harvey Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title | Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_full | Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_fullStr | Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_full_unstemmed | Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_short | Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_sort | molecular cellular and model organism approaches for understanding the basis of neurological disease |
| topic | RC321-571 Q1-390 Stem Cells glycine receptor Amyotrophic Lateral Sclerosis Parkinson's disease PET imaging LRRK2 Zebrafish Inflammation GABA-A receptor NMDA receptors Intellectual Disability thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Stem Cells glycine receptor Amyotrophic Lateral Sclerosis Parkinson's disease PET imaging LRRK2 Zebrafish Inflammation GABA-A receptor NMDA receptors Intellectual Disability thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 23478 |
| work_keys_str_mv | AT robertjharvey molecularcellularandmodelorganismapproachesforunderstandingthebasisofneurologicaldisease AT kirstenharvey molecularcellularandmodelorganismapproachesforunderstandingthebasisofneurologicaldisease |