MR Spectroscopy in Neuropsychiatry
Neuropsychiatric disorders, covering both psychotic and depressive disorders, but also autism and attention-deficit hyperactivity disorder (ADHD), are characterized by abnormal behavior and brain structure. Accumulating evidence suggests that altered neurochemistry plays a role in these disorders an...
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| Principais autores: | , , , |
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| Formato: | Online |
| Idioma: | inglês |
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Frontiers Media SA
2021
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| Acesso em linha: | 31934 |
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| _version_ | 1869514681054396416 |
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| author | Alice Egerton Hilleke Hulshoff Pol Anouk Marsman Brian V. Broberg |
| author_browse | Alice Egerton Anouk Marsman Brian V. Broberg Hilleke Hulshoff Pol |
| author_facet | Alice Egerton Hilleke Hulshoff Pol Anouk Marsman Brian V. Broberg |
| author_sort | Alice Egerton |
| collection | Directory of Open Access Books |
| description | Neuropsychiatric disorders, covering both psychotic and depressive disorders, but also autism and attention-deficit hyperactivity disorder (ADHD), are characterized by abnormal behavior and brain structure. Accumulating evidence suggests that altered neurochemistry plays a role in these disorders and may have a causal relationship with the observed behavioral and structural abnormalities. To improve the understanding of neurochemical anomalies and (patho)physiological changes in psychiatric conditions, in vivo assessment of the affected tissue, the brain, is wanted and needed. Magnetic resonance spectroscopy (MRS) is a non-invasive technique which allows in vivo assessment of the molecular composition of brain tissues and identification of metabolites involved in physiological and pathological processes, which is otherwise virtually impossible. Only in the last decade with the development of high field MR methodologies, MRS has become sensitive enough for broader use in clinical studies. The implications are many, but proper guidance and elucidation of the pros and cons for the specific methods is needed to optimally exploit the potential. This Research Topic updates the reader on the possibilities and pitfalls of MRS today and highlights methodologies and applications for the future. |
| format | Online |
| id | doab-20.500.12854ir-54024 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-540242024-03-30T23:21:39Z MR Spectroscopy in Neuropsychiatry Alice Egerton Hilleke Hulshoff Pol Anouk Marsman Brian V. Broberg R5-920 RC435-571 Neurochemistry Neuroimaging Schizophrenia GABA 7 Tesla MRI Glutamate Functional MRS Psychiatry MR spectroscopy thema EDItEUR::M Medicine and Nursing Neuropsychiatric disorders, covering both psychotic and depressive disorders, but also autism and attention-deficit hyperactivity disorder (ADHD), are characterized by abnormal behavior and brain structure. Accumulating evidence suggests that altered neurochemistry plays a role in these disorders and may have a causal relationship with the observed behavioral and structural abnormalities. To improve the understanding of neurochemical anomalies and (patho)physiological changes in psychiatric conditions, in vivo assessment of the affected tissue, the brain, is wanted and needed. Magnetic resonance spectroscopy (MRS) is a non-invasive technique which allows in vivo assessment of the molecular composition of brain tissues and identification of metabolites involved in physiological and pathological processes, which is otherwise virtually impossible. Only in the last decade with the development of high field MR methodologies, MRS has become sensitive enough for broader use in clinical studies. The implications are many, but proper guidance and elucidation of the pros and cons for the specific methods is needed to optimally exploit the potential. This Research Topic updates the reader on the possibilities and pitfalls of MRS today and highlights methodologies and applications for the future. 2021-02-11T20:15:48Z 2021-02-11T20:15:48Z 2019-01-23 14:53:42 2018 book 31934 16648714 9782889455249 https://directory.doabooks.org/handle/20.500.12854/54024 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4935/mr-spectroscopy-in-neuropsychiatry Frontiers Media SA 10.3389/978-2-88945-524-9 10.3389/978-2-88945-524-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455249 90 open access |
| spellingShingle | R5-920 RC435-571 Neurochemistry Neuroimaging Schizophrenia GABA 7 Tesla MRI Glutamate Functional MRS Psychiatry MR spectroscopy thema EDItEUR::M Medicine and Nursing Alice Egerton Hilleke Hulshoff Pol Anouk Marsman Brian V. Broberg MR Spectroscopy in Neuropsychiatry |
| title | MR Spectroscopy in Neuropsychiatry |
| title_full | MR Spectroscopy in Neuropsychiatry |
| title_fullStr | MR Spectroscopy in Neuropsychiatry |
| title_full_unstemmed | MR Spectroscopy in Neuropsychiatry |
| title_short | MR Spectroscopy in Neuropsychiatry |
| title_sort | mr spectroscopy in neuropsychiatry |
| topic | R5-920 RC435-571 Neurochemistry Neuroimaging Schizophrenia GABA 7 Tesla MRI Glutamate Functional MRS Psychiatry MR spectroscopy thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC435-571 Neurochemistry Neuroimaging Schizophrenia GABA 7 Tesla MRI Glutamate Functional MRS Psychiatry MR spectroscopy thema EDItEUR::M Medicine and Nursing |
| url | 31934 |
| work_keys_str_mv | AT aliceegerton mrspectroscopyinneuropsychiatry AT hillekehulshoffpol mrspectroscopyinneuropsychiatry AT anoukmarsman mrspectroscopyinneuropsychiatry AT brianvbroberg mrspectroscopyinneuropsychiatry |