A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen
Stenotrophomonas maltophilia is a Gram-negative bacterium found in water, plant rhizospheres, animals, and foods. It is associated with a variety of infections in humans, involving respiratory tract (most common), soft tissue and bone, blood, eye, heart, and brain. This opportunistic pathogen is of...
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Frontiers Media SA
2021
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| author | Joanna S. Brooke Gabriele Berg Giovanni Di Bonaventura Jose-Luis Martinez |
| author_browse | Gabriele Berg Giovanni Di Bonaventura Joanna S. Brooke Jose-Luis Martinez |
| author_facet | Joanna S. Brooke Gabriele Berg Giovanni Di Bonaventura Jose-Luis Martinez |
| author_sort | Joanna S. Brooke |
| collection | Directory of Open Access Books |
| description | Stenotrophomonas maltophilia is a Gram-negative bacterium found in water, plant rhizospheres, animals, and foods. It is associated with a variety of infections in humans, involving respiratory tract (most common), soft tissue and bone, blood, eye, heart, and brain. This opportunistic pathogen is of serious concern to the immunocompromised patient population, and it is also being isolated with increasing frequency from the respiratory tract of individuals with cystic fibrosis. The observed increase worldwide in antibiotic resistance and the ability of this organism to make biofilms on epithelial cells and medical devices make it difficult for health-care personnel to treat infections caused by this pathogen. Recently, several genomes of S. maltophilia have been sequenced, revealing high genetic diversity among isolates. This pathogen uses a variety of molecular mechanisms to acquire and demonstrate resistance to an impressive array of antimicrobial drugs. Research has also focused on the pathogenesis of S. maltophilia in animal models and the resulting host immune response. S. maltophilia is recognized as an important organism in the plant microbiome. This environmental bacterium uses a diffusible signal mechanism for controlling its colonization and interaction with other bacteria and plants. S. maltophilia has also gained considerable research interest for its biotechnological applications, with recent studies on enzyme production, anti-biofilm strategies, biodegradation, and bioremediation. This e-book focuses on the latest developments in the areas of physiology, genomics, infection and immunity, host-pathogen interaction, pathogenesis, antimicrobial resistance and therapy, molecular epidemiology, applied and environmental microbiology, bioremediation and biotechnology. |
| format | Online |
| id | doab-20.500.12854ir-54061 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-540612024-04-05T17:31:02Z A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen Joanna S. Brooke Gabriele Berg Giovanni Di Bonaventura Jose-Luis Martinez QR1-502 Q1-390 Stenotrophomonas maltophilia antibiotic resistance mechanisms bioremediation cystic fibrosis iron antimicrobial activity biofilms biocontrol thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Stenotrophomonas maltophilia is a Gram-negative bacterium found in water, plant rhizospheres, animals, and foods. It is associated with a variety of infections in humans, involving respiratory tract (most common), soft tissue and bone, blood, eye, heart, and brain. This opportunistic pathogen is of serious concern to the immunocompromised patient population, and it is also being isolated with increasing frequency from the respiratory tract of individuals with cystic fibrosis. The observed increase worldwide in antibiotic resistance and the ability of this organism to make biofilms on epithelial cells and medical devices make it difficult for health-care personnel to treat infections caused by this pathogen. Recently, several genomes of S. maltophilia have been sequenced, revealing high genetic diversity among isolates. This pathogen uses a variety of molecular mechanisms to acquire and demonstrate resistance to an impressive array of antimicrobial drugs. Research has also focused on the pathogenesis of S. maltophilia in animal models and the resulting host immune response. S. maltophilia is recognized as an important organism in the plant microbiome. This environmental bacterium uses a diffusible signal mechanism for controlling its colonization and interaction with other bacteria and plants. S. maltophilia has also gained considerable research interest for its biotechnological applications, with recent studies on enzyme production, anti-biofilm strategies, biodegradation, and bioremediation. This e-book focuses on the latest developments in the areas of physiology, genomics, infection and immunity, host-pathogen interaction, pathogenesis, antimicrobial resistance and therapy, molecular epidemiology, applied and environmental microbiology, bioremediation and biotechnology. 2021-02-11T20:18:58Z 2021-02-11T20:18:58Z 2018-02-27 16:16:45 2017 book 25653 16648714 9782889453535 https://directory.doabooks.org/handle/20.500.12854/54061 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/books/A_Multidisciplinary_Look_at_Stenotrophomonas_maltophilia_An_Emerging_Multi-Drug-Resistant_Global_Op/1411 https://www.frontiersin.org/research-topics/2478/a-multidisciplinary-look-at-stenotrophomonas-maltophilia-an-emerging-multi-drug-resistant-global-opp Frontiers Media SA 10.3389/978-2-88945-353-5 10.3389/978-2-88945-353-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889453535 133 open access |
| spellingShingle | QR1-502 Q1-390 Stenotrophomonas maltophilia antibiotic resistance mechanisms bioremediation cystic fibrosis iron antimicrobial activity biofilms biocontrol thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Joanna S. Brooke Gabriele Berg Giovanni Di Bonaventura Jose-Luis Martinez A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen |
| title | A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen |
| title_full | A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen |
| title_fullStr | A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen |
| title_full_unstemmed | A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen |
| title_short | A Multidisciplinary Look at Stenotrophomonas maltophilia: An Emerging Multi-Drug-Resistant Global Opportunistic Pathogen |
| title_sort | multidisciplinary look at stenotrophomonas maltophilia an emerging multi drug resistant global opportunistic pathogen |
| topic | QR1-502 Q1-390 Stenotrophomonas maltophilia antibiotic resistance mechanisms bioremediation cystic fibrosis iron antimicrobial activity biofilms biocontrol thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | QR1-502 Q1-390 Stenotrophomonas maltophilia antibiotic resistance mechanisms bioremediation cystic fibrosis iron antimicrobial activity biofilms biocontrol thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | 25653 |
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