Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms
Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in mo...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Online |
| Dil: | İngilizce |
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Frontiers Media SA
2021
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| Konular: | |
| Online Erişim: | 22954 |
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| _version_ | 1869518905615056896 |
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| author | Paolo Bonaldo Cesare Faldini Luciano Merlini |
| author_browse | Cesare Faldini Luciano Merlini Paolo Bonaldo |
| author_facet | Paolo Bonaldo Cesare Faldini Luciano Merlini |
| author_sort | Paolo Bonaldo |
| collection | Directory of Open Access Books |
| description | Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions. |
| format | Online |
| id | doab-20.500.12854ir-54099 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-540992024-04-05T12:35:56Z Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms Paolo Bonaldo Cesare Faldini Luciano Merlini RC321-571 Q1-390 Nanoparticles congenital muscular dystrophy Stem/progenitor cells therapy Aging Parkinson's camptocormia Muscle innervation Animal Models Tendon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions. 2021-02-11T20:21:07Z 2021-02-11T20:21:07Z 2017-07-06 13:27:36 2017 book 22954 16648714 9782889451036 https://directory.doabooks.org/handle/20.500.12854/54099 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Muscle-Tendon-Innervation_Unit_Degeneration_and_Aging_-_Pathophysiological_and_Regeneration_Mechani/1130#nogo http://journal.frontiersin.org/researchtopic/3777/muscle-tendon-innervation-unit-degeneration-and-aging---pathophysiological-and-regeneration-mechanis Frontiers Media SA 10.3389/978-2-88945-103-6 10.3389/978-2-88945-103-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889451036 104 open access |
| spellingShingle | RC321-571 Q1-390 Nanoparticles congenital muscular dystrophy Stem/progenitor cells therapy Aging Parkinson's camptocormia Muscle innervation Animal Models Tendon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Paolo Bonaldo Cesare Faldini Luciano Merlini Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms |
| title | Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms |
| title_full | Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms |
| title_fullStr | Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms |
| title_full_unstemmed | Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms |
| title_short | Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms |
| title_sort | muscle tendon innervation unit degeneration and aging pathophysiological and regeneration mechanisms |
| topic | RC321-571 Q1-390 Nanoparticles congenital muscular dystrophy Stem/progenitor cells therapy Aging Parkinson's camptocormia Muscle innervation Animal Models Tendon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Nanoparticles congenital muscular dystrophy Stem/progenitor cells therapy Aging Parkinson's camptocormia Muscle innervation Animal Models Tendon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 22954 |
| work_keys_str_mv | AT paolobonaldo muscletendoninnervationunitdegenerationandagingpathophysiologicalandregenerationmechanisms AT cesarefaldini muscletendoninnervationunitdegenerationandagingpathophysiologicalandregenerationmechanisms AT lucianomerlini muscletendoninnervationunitdegenerationandagingpathophysiologicalandregenerationmechanisms |