Mysteries of Type I IFN response: benefits versus detriments
Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IF...
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| Autores principales: | , , |
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| Formato: | Online |
| Lenguaje: | inglés |
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Frontiers Media SA
2021
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| Acceso en línea: | 19536 |
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| _version_ | 1869522046791188480 |
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| author | Herbert Patrick Ludewick Arno Mullbacher Yoichi Furuya |
| author_browse | Arno Mullbacher Herbert Patrick Ludewick Yoichi Furuya |
| author_facet | Herbert Patrick Ludewick Arno Mullbacher Yoichi Furuya |
| author_sort | Herbert Patrick Ludewick |
| collection | Directory of Open Access Books |
| description | Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IFN-I could serve as a double edge sword, either containing an infection or enhancing susceptibility. For example, IFN-I, which is essential for early containment of viral infections, has been shown to be detrimental to the host during bacterial infections. In fact, recent significant reports have shown that influenza virus induced IFN-I responses can enhance the host susceptibility to secondary bacterial infections. These recent reports highlight the expanding immunoregulatory role of IFN-I in the host immunity. With these recent findings in mind, the aim of this research topic is to welcome novel data, opinion and literature reviews on the newly identified dual functions of IFN-I. This research topic wills focus on the following areas of IFN-I: 1) a detrimental role of IFN-I during primary bacterial infection; 2) a detrimental role of viral infection induced IFN-I during secondary bacterial infections; 3) evolutionary pressure that drove detrimental IFN-I response during primary bacterial infection; and 4) does benefit of IFN-I responses during primary viral infections outweigh the adverse consequences of IFN-I mediated enhanced susceptibility to secondary bacterial infections. |
| format | Online |
| id | doab-20.500.12854ir-54188 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-541882024-03-30T23:22:57Z Mysteries of Type I IFN response: benefits versus detriments Herbert Patrick Ludewick Arno Mullbacher Yoichi Furuya R5-920 RC581-607 Autoimmunity adjuvant bacterial and viral infections Vaccine type I IFN thema EDItEUR::M Medicine and Nursing Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IFN-I could serve as a double edge sword, either containing an infection or enhancing susceptibility. For example, IFN-I, which is essential for early containment of viral infections, has been shown to be detrimental to the host during bacterial infections. In fact, recent significant reports have shown that influenza virus induced IFN-I responses can enhance the host susceptibility to secondary bacterial infections. These recent reports highlight the expanding immunoregulatory role of IFN-I in the host immunity. With these recent findings in mind, the aim of this research topic is to welcome novel data, opinion and literature reviews on the newly identified dual functions of IFN-I. This research topic wills focus on the following areas of IFN-I: 1) a detrimental role of IFN-I during primary bacterial infection; 2) a detrimental role of viral infection induced IFN-I during secondary bacterial infections; 3) evolutionary pressure that drove detrimental IFN-I response during primary bacterial infection; and 4) does benefit of IFN-I responses during primary viral infections outweigh the adverse consequences of IFN-I mediated enhanced susceptibility to secondary bacterial infections. 2021-02-11T20:27:24Z 2021-02-11T20:27:24Z 2016-08-16 10:34:25 2015 book 19536 16648714 9782889196296 https://directory.doabooks.org/handle/20.500.12854/54188 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Mysteries_of_Type_I_IFN_response_benefits_versus_detriments/660 http://journal.frontiersin.org/researchtopic/2095/mysteries-of-type-i-ifn-response-benefits-versus-detriments Frontiers Media SA 10.3389/978-2-88919-629-6 10.3389/978-2-88919-629-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196296 74 open access |
| spellingShingle | R5-920 RC581-607 Autoimmunity adjuvant bacterial and viral infections Vaccine type I IFN thema EDItEUR::M Medicine and Nursing Herbert Patrick Ludewick Arno Mullbacher Yoichi Furuya Mysteries of Type I IFN response: benefits versus detriments |
| title | Mysteries of Type I IFN response: benefits versus detriments |
| title_full | Mysteries of Type I IFN response: benefits versus detriments |
| title_fullStr | Mysteries of Type I IFN response: benefits versus detriments |
| title_full_unstemmed | Mysteries of Type I IFN response: benefits versus detriments |
| title_short | Mysteries of Type I IFN response: benefits versus detriments |
| title_sort | mysteries of type i ifn response benefits versus detriments |
| topic | R5-920 RC581-607 Autoimmunity adjuvant bacterial and viral infections Vaccine type I IFN thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Autoimmunity adjuvant bacterial and viral infections Vaccine type I IFN thema EDItEUR::M Medicine and Nursing |
| url | 19536 |
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