Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems
Decades of research have identified a role for dopamine neurotransmission in prefrontal cortical function and flexible cognition. Abnormal dopamine neurotransmission underlies many cases of cognitive dysfunction. New techniques using optogenetics have allowed for ever more precise functional segrega...
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| मुख्य लेखकों: | , |
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| स्वरूप: | Online |
| भाषा: | अंग्रेज़ी |
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Frontiers Media SA
2021
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| विषय: | |
| ऑनलाइन पहुंच: | 18906 |
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कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
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| _version_ | 1869521094080200704 |
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| author | Matthew R. Roesch Gregory B. Bissonette |
| author_browse | Gregory B. Bissonette Matthew R. Roesch |
| author_facet | Matthew R. Roesch Gregory B. Bissonette |
| author_sort | Matthew R. Roesch |
| collection | Directory of Open Access Books |
| description | Decades of research have identified a role for dopamine neurotransmission in prefrontal cortical function and flexible cognition. Abnormal dopamine neurotransmission underlies many cases of cognitive dysfunction. New techniques using optogenetics have allowed for ever more precise functional segregation of areas within the prefrontal cortex, which underlie separate cognitive functions. Learning theory predictions have provided a very useful framework for interpreting the neural activity of dopamine neurons, yet even dopamine neurons present a range of responses, from salience to prediction error signaling. The functions of areas like the Lateral Habenula have been recently described, and its role, presumed to be substantial, is largely unknown. Many other neural systems interact with the dopamine system, like cortical GABAergic interneurons, making it critical to understand those systems and their interactions with dopamine in order to fully appreciate dopamine's role in flexible behavior. Advances in human clinical research, like exome sequencing, are driving experimental hypotheses which will lead to fruitful new research directions, but how do (or should?) these clinical findings inform basic research? Following new information from these techniques, we may begin to develop a fresh understanding of human disease states which will inform novel treatment possibilities. However, we need an operational framework with which to interpret these new findings. Therefore, the purpose of this Research Topic is to integrate what we know of dopamine, the prefrontal cortex and flexible behavior into a clear framework, which will illuminate clear, testable directions for future research. |
| format | Online |
| id | doab-20.500.12854ir-54469 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-544692024-04-05T12:36:10Z Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems Matthew R. Roesch Gregory B. Bissonette RC321-571 Q1-390 behavioral flexibility Dopamine medial prefrontal cortex (mPFC) Attentional set-shifting basal forebrain anterior cingulate cortex (ACC) endocannabinoid system lateral habenula (LHb) Locus coeruleus (LC) motivational salience thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Decades of research have identified a role for dopamine neurotransmission in prefrontal cortical function and flexible cognition. Abnormal dopamine neurotransmission underlies many cases of cognitive dysfunction. New techniques using optogenetics have allowed for ever more precise functional segregation of areas within the prefrontal cortex, which underlie separate cognitive functions. Learning theory predictions have provided a very useful framework for interpreting the neural activity of dopamine neurons, yet even dopamine neurons present a range of responses, from salience to prediction error signaling. The functions of areas like the Lateral Habenula have been recently described, and its role, presumed to be substantial, is largely unknown. Many other neural systems interact with the dopamine system, like cortical GABAergic interneurons, making it critical to understand those systems and their interactions with dopamine in order to fully appreciate dopamine's role in flexible behavior. Advances in human clinical research, like exome sequencing, are driving experimental hypotheses which will lead to fruitful new research directions, but how do (or should?) these clinical findings inform basic research? Following new information from these techniques, we may begin to develop a fresh understanding of human disease states which will inform novel treatment possibilities. However, we need an operational framework with which to interpret these new findings. Therefore, the purpose of this Research Topic is to integrate what we know of dopamine, the prefrontal cortex and flexible behavior into a clear framework, which will illuminate clear, testable directions for future research. 2021-02-11T20:47:45Z 2021-02-11T20:47:45Z 2016-04-07 11:22:02 2016 book 18906 16648714 9782889197958 https://directory.doabooks.org/handle/20.500.12854/54469 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Neural_Circuitry_of_Behavioral_Flexibility_Dopamine_and_Related_Systems/833 http://journal.frontiersin.org/researchtopic/3523/neural-circuitry-of-behavioral-flexibility-dopamine-and-related-systems Frontiers Media SA 10.3389/978-2-88919-795-8 10.3389/978-2-88919-795-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197958 165 open access |
| spellingShingle | RC321-571 Q1-390 behavioral flexibility Dopamine medial prefrontal cortex (mPFC) Attentional set-shifting basal forebrain anterior cingulate cortex (ACC) endocannabinoid system lateral habenula (LHb) Locus coeruleus (LC) motivational salience thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Matthew R. Roesch Gregory B. Bissonette Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems |
| title | Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems |
| title_full | Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems |
| title_fullStr | Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems |
| title_full_unstemmed | Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems |
| title_short | Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems |
| title_sort | neural circuitry of behavioral flexibility dopamine and related systems |
| topic | RC321-571 Q1-390 behavioral flexibility Dopamine medial prefrontal cortex (mPFC) Attentional set-shifting basal forebrain anterior cingulate cortex (ACC) endocannabinoid system lateral habenula (LHb) Locus coeruleus (LC) motivational salience thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 behavioral flexibility Dopamine medial prefrontal cortex (mPFC) Attentional set-shifting basal forebrain anterior cingulate cortex (ACC) endocannabinoid system lateral habenula (LHb) Locus coeruleus (LC) motivational salience thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18906 |
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