Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis
Ethanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has tradit...
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| Fformat: | Online |
| Iaith: | Saesneg |
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Frontiers Media SA
2021
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| Pynciau: | |
| Mynediad Ar-lein: | 17704 |
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Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869516861397270528 |
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| author | Elio Acquas John D Salamone |
| author_browse | Elio Acquas John D Salamone |
| author_facet | Elio Acquas John D Salamone |
| author_sort | Elio Acquas |
| collection | Directory of Open Access Books |
| description | Ethanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has traditionally been known as a toxic substance with several effects on multiple systems. However, in the last few decades evidence has accumulated to reveal the specific and, in some instances, distinct neural actions of acetaldehyde and acetate that are in part responsible for some of the observed psychoactive effects of ethanol. The present issue will address these challenges to provide an up-to-date synopsis of the behavioral and neurophysiological impact of the two direct metabolites of ethanol, acetaldehyde and acetate. In doing so, this issue will present human and rodent evidence on their behavioral and neurophysiological impact, either when administered alone as drugs, or when metabolically-derived from their parent compound. Emphasis will be placed to stress the importance of the different enzymatic systems that intervene to produce these metabolites, either peripherally and/or directly in the brain. Similarly, this Research Topic will be aimed at addressing some of the possible mechanisms of action of acetaldehyde and acetate in different brain areas and in different intracellular systems. Furthermore, the issue will lay out some of the suggested mechanisms of action of ethanol and of its metabolites by which they form adducts with other molecules and neurotransmitters such as dopamine and opioids (which lead to salsolinol and tetrahydropapaveroline, respectively), and their impact on the synthesis and actions of neuromodulators such as adenosine and the cannabinoid system. |
| format | Online |
| id | doab-20.500.12854ir-54488 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-544882024-04-05T12:35:43Z Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis Elio Acquas John D Salamone RC321-571 Q1-390 acetate Drug abuse Salsolinol Dopamine Ethanol Catalase Addiction Opioids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Ethanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has traditionally been known as a toxic substance with several effects on multiple systems. However, in the last few decades evidence has accumulated to reveal the specific and, in some instances, distinct neural actions of acetaldehyde and acetate that are in part responsible for some of the observed psychoactive effects of ethanol. The present issue will address these challenges to provide an up-to-date synopsis of the behavioral and neurophysiological impact of the two direct metabolites of ethanol, acetaldehyde and acetate. In doing so, this issue will present human and rodent evidence on their behavioral and neurophysiological impact, either when administered alone as drugs, or when metabolically-derived from their parent compound. Emphasis will be placed to stress the importance of the different enzymatic systems that intervene to produce these metabolites, either peripherally and/or directly in the brain. Similarly, this Research Topic will be aimed at addressing some of the possible mechanisms of action of acetaldehyde and acetate in different brain areas and in different intracellular systems. Furthermore, the issue will lay out some of the suggested mechanisms of action of ethanol and of its metabolites by which they form adducts with other molecules and neurotransmitters such as dopamine and opioids (which lead to salsolinol and tetrahydropapaveroline, respectively), and their impact on the synthesis and actions of neuromodulators such as adenosine and the cannabinoid system. 2021-02-11T20:48:46Z 2021-02-11T20:48:46Z 2015-11-19 16:29:12 2015 book 17704 16648714 9782889193752 https://directory.doabooks.org/handle/20.500.12854/54488 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Neuroactive_metabolites_of_ethanol_a_behavioral_and_neurochemical_synopsis/434 http://journal.frontiersin.org/researchtopic/1111/neuroactive-metabolites-of-ethanol-a-behavioral-and-neurochemical-synopsis Frontiers Media SA 10.3389/978-2-88919-375-2 10.3389/978-2-88919-375-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193752 126 open access |
| spellingShingle | RC321-571 Q1-390 acetate Drug abuse Salsolinol Dopamine Ethanol Catalase Addiction Opioids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Elio Acquas John D Salamone Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis |
| title | Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis |
| title_full | Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis |
| title_fullStr | Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis |
| title_full_unstemmed | Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis |
| title_short | Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis |
| title_sort | neuroactive metabolites of ethanol a behavioral and neurochemical synopsis |
| topic | RC321-571 Q1-390 acetate Drug abuse Salsolinol Dopamine Ethanol Catalase Addiction Opioids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 acetate Drug abuse Salsolinol Dopamine Ethanol Catalase Addiction Opioids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17704 |
| work_keys_str_mv | AT elioacquas neuroactivemetabolitesofethanolabehavioralandneurochemicalsynopsis AT johndsalamone neuroactivemetabolitesofethanolabehavioralandneurochemicalsynopsis |