Neuroanatomy and transgenic technologies
Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vecto...
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| Main Authors: | , , , , |
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| 格式: | Online |
| 語言: | 英语 |
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Frontiers Media SA
2021
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| 主題: | |
| 在線閱讀: | 17748 |
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| _version_ | 1869513874830524416 |
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| author | Laurent Gautron Alexander C Jackson Chen Liu Makoto Fukuda Michael Lazarus |
| author_browse | Alexander C Jackson Chen Liu Laurent Gautron Makoto Fukuda Michael Lazarus |
| author_facet | Laurent Gautron Alexander C Jackson Chen Liu Makoto Fukuda Michael Lazarus |
| author_sort | Laurent Gautron |
| collection | Directory of Open Access Books |
| description | Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions. |
| format | Online |
| id | doab-20.500.12854ir-54489 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-544892024-04-05T12:35:18Z Neuroanatomy and transgenic technologies Laurent Gautron Alexander C Jackson Chen Liu Makoto Fukuda Michael Lazarus RC321-571 Q1-390 gene delivery mouse models tracing transgenesis morphology adeno-associated virus Fluorescent reporters neuronal circuits thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions. 2021-02-11T20:48:49Z 2021-02-11T20:48:49Z 2015-12-03 13:02:24 2015 book 17748 16648714 9782889195138 https://directory.doabooks.org/handle/20.500.12854/54489 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Neuroanatomy_and_transgenic_technologies/502#nogo http://journal.frontiersin.org/researchtopic/1685/neuroanatomy-and-transgenic-technologies Frontiers Media SA 10.3389/978-2-88919-513-8 10.3389/978-2-88919-513-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195138 139 open access |
| spellingShingle | RC321-571 Q1-390 gene delivery mouse models tracing transgenesis morphology adeno-associated virus Fluorescent reporters neuronal circuits thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Laurent Gautron Alexander C Jackson Chen Liu Makoto Fukuda Michael Lazarus Neuroanatomy and transgenic technologies |
| title | Neuroanatomy and transgenic technologies |
| title_full | Neuroanatomy and transgenic technologies |
| title_fullStr | Neuroanatomy and transgenic technologies |
| title_full_unstemmed | Neuroanatomy and transgenic technologies |
| title_short | Neuroanatomy and transgenic technologies |
| title_sort | neuroanatomy and transgenic technologies |
| topic | RC321-571 Q1-390 gene delivery mouse models tracing transgenesis morphology adeno-associated virus Fluorescent reporters neuronal circuits thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 gene delivery mouse models tracing transgenesis morphology adeno-associated virus Fluorescent reporters neuronal circuits thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17748 |
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