Neurobiological circuit function and computation of the serotonergic and related systems
Serotonin is one of the oldest neurotransmitters in evolutionary terms, and the serotonergic system is complex and multifaceted. Serotonin-producing neurons in the raphe nuclei provide serotonin innervations throughout various parts of the brain, modulating cellular excitability and network properti...
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| Format: | Online |
| Sprache: | Englisch |
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Frontiers Media SA
2021
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| author | Kae Nakamura KongFatt Wong-Lin |
| author_browse | Kae Nakamura KongFatt Wong-Lin |
| author_facet | Kae Nakamura KongFatt Wong-Lin |
| author_sort | Kae Nakamura |
| collection | Directory of Open Access Books |
| description | Serotonin is one of the oldest neurotransmitters in evolutionary terms, and the serotonergic system is complex and multifaceted. Serotonin-producing neurons in the raphe nuclei provide serotonin innervations throughout various parts of the brain, modulating cellular excitability and network properties of targeted brain areas, and regulating mood, cognition and behavior. Dysfunctions of the serotonergic system are implicated in neuropsychiatric disorders including depression, schizophrenia, and drug abuse. Although the system has been studied for many years, an integrative account of its functions and computational principles remains elusive. This is partly attributed to the high variability and heterogeneity in terms of neuronal properties and receptor types, and its extensive connections with other brain regions. This Frontiers Research Topic e-book is a collection of recent experimental and computational work and approaches at multiple scales that provide the latest information regarding the integrated functions of the serotonergic system. The contributed papers include a variety of experimental and computational work, and human clinical studies. |
| format | Online |
| id | doab-20.500.12854ir-54492 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-544922024-04-05T17:31:09Z Neurobiological circuit function and computation of the serotonergic and related systems Kae Nakamura KongFatt Wong-Lin RC321-571 Q1-390 dorsal raphe nucleus Locus Coeruleus neural circuit Dopamine Serotonin pendunculopontine tegmental nucleus serotonin 5-HT computational modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Serotonin is one of the oldest neurotransmitters in evolutionary terms, and the serotonergic system is complex and multifaceted. Serotonin-producing neurons in the raphe nuclei provide serotonin innervations throughout various parts of the brain, modulating cellular excitability and network properties of targeted brain areas, and regulating mood, cognition and behavior. Dysfunctions of the serotonergic system are implicated in neuropsychiatric disorders including depression, schizophrenia, and drug abuse. Although the system has been studied for many years, an integrative account of its functions and computational principles remains elusive. This is partly attributed to the high variability and heterogeneity in terms of neuronal properties and receptor types, and its extensive connections with other brain regions. This Frontiers Research Topic e-book is a collection of recent experimental and computational work and approaches at multiple scales that provide the latest information regarding the integrated functions of the serotonergic system. The contributed papers include a variety of experimental and computational work, and human clinical studies. 2021-02-11T20:49:00Z 2021-02-11T20:49:00Z 2015-12-03 13:02:24 2015 book 17754 16648714 9782889193844 https://directory.doabooks.org/handle/20.500.12854/54492 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Neurobiological_circuit_function_and_computation_of_the_serotonergic_and_related_systems/442#nogo http://journal.frontiersin.org/researchtopic/844/neurobiological-circuit-function-and-computation-of-the-serotonergic-and-related-systems Frontiers Media SA 10.3389/978-2-88919-384-4 10.3389/978-2-88919-384-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193844 165 open access |
| spellingShingle | RC321-571 Q1-390 dorsal raphe nucleus Locus Coeruleus neural circuit Dopamine Serotonin pendunculopontine tegmental nucleus serotonin 5-HT computational modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Kae Nakamura KongFatt Wong-Lin Neurobiological circuit function and computation of the serotonergic and related systems |
| title | Neurobiological circuit function and computation of the serotonergic and related systems |
| title_full | Neurobiological circuit function and computation of the serotonergic and related systems |
| title_fullStr | Neurobiological circuit function and computation of the serotonergic and related systems |
| title_full_unstemmed | Neurobiological circuit function and computation of the serotonergic and related systems |
| title_short | Neurobiological circuit function and computation of the serotonergic and related systems |
| title_sort | neurobiological circuit function and computation of the serotonergic and related systems |
| topic | RC321-571 Q1-390 dorsal raphe nucleus Locus Coeruleus neural circuit Dopamine Serotonin pendunculopontine tegmental nucleus serotonin 5-HT computational modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 dorsal raphe nucleus Locus Coeruleus neural circuit Dopamine Serotonin pendunculopontine tegmental nucleus serotonin 5-HT computational modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17754 |
| work_keys_str_mv | AT kaenakamura neurobiologicalcircuitfunctionandcomputationoftheserotonergicandrelatedsystems AT kongfattwonglin neurobiologicalcircuitfunctionandcomputationoftheserotonergicandrelatedsystems |