Neuroglia Molecular Mechanisms in Psychiatric Disorders
Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. I...
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| Format: | Online |
| Langue: | anglais |
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Frontiers Media SA
2021
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| Accès en ligne: | 32073 |
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| _version_ | 1869520027826257920 |
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| author | Caterina Scuderi Mami Noda Alexei Verkhratsky |
| author_browse | Alexei Verkhratsky Caterina Scuderi Mami Noda |
| author_facet | Caterina Scuderi Mami Noda Alexei Verkhratsky |
| author_sort | Caterina Scuderi |
| collection | Directory of Open Access Books |
| description | Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders. |
| format | Online |
| id | doab-20.500.12854ir-54502 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-545022024-04-05T12:36:03Z Neuroglia Molecular Mechanisms in Psychiatric Disorders Caterina Scuderi Mami Noda Alexei Verkhratsky RC321-571 Q1-390 Neuropsychiatric Disorders Alcohol Use Disorders Neurovascular Disorders Neuroglia Schizophrenia. Major Depression thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders. 2021-02-11T20:49:35Z 2021-02-11T20:49:35Z 2019-01-23 14:53:43 2019 book 32073 16648714 9782889456987 https://directory.doabooks.org/handle/20.500.12854/54502 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5533/neuroglia-molecular-mechanisms-in-psychiatric-disorders Frontiers Media SA 10.3389/978-2-88945-698-7 10.3389/978-2-88945-698-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456987 154 open access |
| spellingShingle | RC321-571 Q1-390 Neuropsychiatric Disorders Alcohol Use Disorders Neurovascular Disorders Neuroglia Schizophrenia. Major Depression thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Caterina Scuderi Mami Noda Alexei Verkhratsky Neuroglia Molecular Mechanisms in Psychiatric Disorders |
| title | Neuroglia Molecular Mechanisms in Psychiatric Disorders |
| title_full | Neuroglia Molecular Mechanisms in Psychiatric Disorders |
| title_fullStr | Neuroglia Molecular Mechanisms in Psychiatric Disorders |
| title_full_unstemmed | Neuroglia Molecular Mechanisms in Psychiatric Disorders |
| title_short | Neuroglia Molecular Mechanisms in Psychiatric Disorders |
| title_sort | neuroglia molecular mechanisms in psychiatric disorders |
| topic | RC321-571 Q1-390 Neuropsychiatric Disorders Alcohol Use Disorders Neurovascular Disorders Neuroglia Schizophrenia. Major Depression thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Neuropsychiatric Disorders Alcohol Use Disorders Neurovascular Disorders Neuroglia Schizophrenia. Major Depression thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 32073 |
| work_keys_str_mv | AT caterinascuderi neurogliamolecularmechanismsinpsychiatricdisorders AT maminoda neurogliamolecularmechanismsinpsychiatricdisorders AT alexeiverkhratsky neurogliamolecularmechanismsinpsychiatricdisorders |