Neuromodulation of Executive Circuits
High-order executive tasks involve the interplay between frontal cortex and other cortical and subcortical brain regions. In particular, the frontal cortex, striatum and thalamus interact via parallel fronto-striatal "loops" that are crucial for the executive control of behavior. In all of these bra...
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Frontiers Media SA
2021
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| Online adgang: | 18829 |
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| author | Evelyn K. Lambe Allan T. Gulledge Guillermo Gonzalez-Burgos M. Victoria Puig |
| author_browse | Allan T. Gulledge Evelyn K. Lambe Guillermo Gonzalez-Burgos M. Victoria Puig |
| author_facet | Evelyn K. Lambe Allan T. Gulledge Guillermo Gonzalez-Burgos M. Victoria Puig |
| author_sort | Evelyn K. Lambe |
| collection | Directory of Open Access Books |
| description | High-order executive tasks involve the interplay between frontal cortex and other cortical and subcortical brain regions. In particular, the frontal cortex, striatum and thalamus interact via parallel fronto-striatal "loops" that are crucial for the executive control of behavior. In all of these brain regions, neuromodulatory inputs (e.g. serotonergic, dopaminergic, cholinergic, adrenergic, and peptidergic afferents) regulate neuronal activity and synaptic transmission to optimize circuit performance for specific cognitive demands. Indeed, dysregulation of neuromodulatory input to fronto-striatal circuits is implicated in a number of neuropsychiatric disorders, such as schizophrenia, depression, and Parkinson's disease. However, despite decades of intense investigation, how neuromodulators influence the activity of fronto-striatal circuits to generate the precise activity patterns required for sophisticated cognitive tasks remains unknown. In part, this reflects the complexity of the cellular microcircuits in these brain regions (i.e. heterogeneity of neuron subtypes and connectivity), cell-type specific expression patterns for the numerous receptor subtypes mediating neuromodulatory signals, and the potential interaction of multiple signaling cascades in individual neurons. This Research Topic includes 10 original research articles and seven review articles addressing the role of neuromodulation in executive function at multiple levels of analysis, ranging from the activity of single voltage-dependent ion channels to computational models of network interactions in cortex-striatum-thalamus systems. |
| format | Online |
| id | doab-20.500.12854ir-54509 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-545092024-04-05T12:35:40Z Neuromodulation of Executive Circuits Evelyn K. Lambe Allan T. Gulledge Guillermo Gonzalez-Burgos M. Victoria Puig RC321-571 Q1-390 Dopamine Serotonin Thalamus noradrenaline Acetylcholine Basal Ganglia Executive Function Prefrontal Cortex thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences High-order executive tasks involve the interplay between frontal cortex and other cortical and subcortical brain regions. In particular, the frontal cortex, striatum and thalamus interact via parallel fronto-striatal "loops" that are crucial for the executive control of behavior. In all of these brain regions, neuromodulatory inputs (e.g. serotonergic, dopaminergic, cholinergic, adrenergic, and peptidergic afferents) regulate neuronal activity and synaptic transmission to optimize circuit performance for specific cognitive demands. Indeed, dysregulation of neuromodulatory input to fronto-striatal circuits is implicated in a number of neuropsychiatric disorders, such as schizophrenia, depression, and Parkinson's disease. However, despite decades of intense investigation, how neuromodulators influence the activity of fronto-striatal circuits to generate the precise activity patterns required for sophisticated cognitive tasks remains unknown. In part, this reflects the complexity of the cellular microcircuits in these brain regions (i.e. heterogeneity of neuron subtypes and connectivity), cell-type specific expression patterns for the numerous receptor subtypes mediating neuromodulatory signals, and the potential interaction of multiple signaling cascades in individual neurons. This Research Topic includes 10 original research articles and seven review articles addressing the role of neuromodulation in executive function at multiple levels of analysis, ranging from the activity of single voltage-dependent ion channels to computational models of network interactions in cortex-striatum-thalamus systems. 2021-02-11T20:50:00Z 2021-02-11T20:50:00Z 2016-04-07 11:22:02 2016 book 18829 16648714 9782889197071 https://directory.doabooks.org/handle/20.500.12854/54509 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Neuromodulation_of_Executive_Circuits/775#nogo http://journal.frontiersin.org/researchtopic/1346/neuromodulation-of-executive-circuits Frontiers Media SA 10.3389/978-2-88919-707-1 10.3389/978-2-88919-707-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197071 257 open access |
| spellingShingle | RC321-571 Q1-390 Dopamine Serotonin Thalamus noradrenaline Acetylcholine Basal Ganglia Executive Function Prefrontal Cortex thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Evelyn K. Lambe Allan T. Gulledge Guillermo Gonzalez-Burgos M. Victoria Puig Neuromodulation of Executive Circuits |
| title | Neuromodulation of Executive Circuits |
| title_full | Neuromodulation of Executive Circuits |
| title_fullStr | Neuromodulation of Executive Circuits |
| title_full_unstemmed | Neuromodulation of Executive Circuits |
| title_short | Neuromodulation of Executive Circuits |
| title_sort | neuromodulation of executive circuits |
| topic | RC321-571 Q1-390 Dopamine Serotonin Thalamus noradrenaline Acetylcholine Basal Ganglia Executive Function Prefrontal Cortex thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Dopamine Serotonin Thalamus noradrenaline Acetylcholine Basal Ganglia Executive Function Prefrontal Cortex thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18829 |
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