Neuronal and glial structural plasticity induced by drugs of abuse
Drugs of abuse induce a host of alterations in brain structure and function, ranging from changes in gene expression and epigenetic processes to aberrant synaptic plasticity to volumetric changes in discrete brain regions. These alterations can be drug class-specific, and are not confined to neurons...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media SA
2021
|
| Subjects: | |
| Online Access: | 18708 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1869520041784901632 |
|---|---|
| author | M Foster Olive Justin Gass |
| author_browse | Justin Gass M Foster Olive |
| author_facet | M Foster Olive Justin Gass |
| author_sort | M Foster Olive |
| collection | Directory of Open Access Books |
| description | Drugs of abuse induce a host of alterations in brain structure and function, ranging from changes in gene expression and epigenetic processes to aberrant synaptic plasticity to volumetric changes in discrete brain regions. These alterations can be drug class-specific, and are not confined to neurons, as drugs of abuse also induce molecular and cellular alterations in various glial cell types such as astrocytes and microglia. The phenomenon of drug-induced plasticity includes changes in dendritic branching and architecture, dendritic spine density and morphology, astrocyte-neuronal interactions, dysregulation of glutamatergic and GABAergic signaling, and alterations in myelination or microglial phenotype. This drug-induced "rewiring" of the brain at numerous levels can contribute to the development, maintenance, and persistence of the addicted state, as well as associated deficits in normal cognitive functioning. The aim of this Research Topic is to collect recent and important findings related to the structural alterations produced by drug of abuse in neurons, glial, and other cell types of the central nervous system. |
| format | Online |
| id | doab-20.500.12854ir-54512 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-545122024-04-01T14:14:55Z Neuronal and glial structural plasticity induced by drugs of abuse M Foster Olive Justin Gass RM1-950 Q1-390 Dopamine Neuron Addiction Spine GABA plasticity Glutamate glia astrocyte Dendrite thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Drugs of abuse induce a host of alterations in brain structure and function, ranging from changes in gene expression and epigenetic processes to aberrant synaptic plasticity to volumetric changes in discrete brain regions. These alterations can be drug class-specific, and are not confined to neurons, as drugs of abuse also induce molecular and cellular alterations in various glial cell types such as astrocytes and microglia. The phenomenon of drug-induced plasticity includes changes in dendritic branching and architecture, dendritic spine density and morphology, astrocyte-neuronal interactions, dysregulation of glutamatergic and GABAergic signaling, and alterations in myelination or microglial phenotype. This drug-induced "rewiring" of the brain at numerous levels can contribute to the development, maintenance, and persistence of the addicted state, as well as associated deficits in normal cognitive functioning. The aim of this Research Topic is to collect recent and important findings related to the structural alterations produced by drug of abuse in neurons, glial, and other cell types of the central nervous system. 2021-02-11T20:50:12Z 2021-02-11T20:50:12Z 2016-03-10 08:14:32 2015 book 18708 16648714 9782889195985 https://directory.doabooks.org/handle/20.500.12854/54512 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Neuronal_and_Glial_Structural_Plasticity_Induced_by_Drugs_of_Abuse/642 http://journal.frontiersin.org/researchtopic/2523/neuronal-and-glial-structural-plasticity-induced-by-drugs-of-abuse Frontiers Media SA 10.3389/978-2-88919-598-5 10.3389/978-2-88919-598-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195985 90 open access |
| spellingShingle | RM1-950 Q1-390 Dopamine Neuron Addiction Spine GABA plasticity Glutamate glia astrocyte Dendrite thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology M Foster Olive Justin Gass Neuronal and glial structural plasticity induced by drugs of abuse |
| title | Neuronal and glial structural plasticity induced by drugs of abuse |
| title_full | Neuronal and glial structural plasticity induced by drugs of abuse |
| title_fullStr | Neuronal and glial structural plasticity induced by drugs of abuse |
| title_full_unstemmed | Neuronal and glial structural plasticity induced by drugs of abuse |
| title_short | Neuronal and glial structural plasticity induced by drugs of abuse |
| title_sort | neuronal and glial structural plasticity induced by drugs of abuse |
| topic | RM1-950 Q1-390 Dopamine Neuron Addiction Spine GABA plasticity Glutamate glia astrocyte Dendrite thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 Q1-390 Dopamine Neuron Addiction Spine GABA plasticity Glutamate glia astrocyte Dendrite thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 18708 |
| work_keys_str_mv | AT mfosterolive neuronalandglialstructuralplasticityinducedbydrugsofabuse AT justingass neuronalandglialstructuralplasticityinducedbydrugsofabuse |