Neuronal Polarity: Establishment and Maintenance
The term polarity in a biological context is used to describe an asymmetry in morphology and distribution of molecules. In neurons, their complex shape with typically one axon and several dendrites reflects this asymmetry. Although neurons assume many different shapes and sizes they always maintain...
I tiakina i:
| Ngā kaituhi matua: | , |
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| Hōputu: | Online |
| Reo: | Ingarihi |
| I whakaputaina: |
Frontiers Media SA
2021
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| Ngā marau: | |
| Urunga tuihono: | 31927 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869515788871794688 |
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| author | Froylan Calderon de Anda Annette Gaertner |
| author_browse | Annette Gaertner Froylan Calderon de Anda |
| author_facet | Froylan Calderon de Anda Annette Gaertner |
| author_sort | Froylan Calderon de Anda |
| collection | Directory of Open Access Books |
| description | The term polarity in a biological context is used to describe an asymmetry in morphology and distribution of molecules. In neurons, their complex shape with typically one axon and several dendrites reflects this asymmetry. Although neurons assume many different shapes and sizes they always maintain these two domains, which are essential for neuronal function. In the most simple view, neurons use their axon to transmit signals over long distances due to its capacity to extend to enormous lengths. Dendrites, on the other hand, are shorter and receive and integrate signals from different locations. The selection of the site where the axon and dendrites initially emerge during embryonic development is a tightly regulated event, eventually important for the correct formation of neuronal circuits, and disturbances of these processes can have pathological consequences due to circuit malformation. An important question is which mechanisms neurons utilize to specify the sites where axonal and dendrite outgrowth occurs and how their identities are maintained during and after development. The formation of these functionally diverse domains is the result of polarized differences of membrane and protein delivery, mitochondria transport, actin dynamics and microtubule stability. However how and in which temporal order all those events which coordinate the selection and maintenance of axons and dendrites is still under investigation. This selection of articles shall highlight new findings, which help to unravel all molecular and cellular events important for neuronal polarity establishment and maintenance. |
| format | Online |
| id | doab-20.500.12854ir-54518 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-545182024-04-05T12:35:32Z Neuronal Polarity: Establishment and Maintenance Froylan Calderon de Anda Annette Gaertner RC321-571 Q1-390 neuronal migration neuronal polarity dendrites neurogenesis axon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The term polarity in a biological context is used to describe an asymmetry in morphology and distribution of molecules. In neurons, their complex shape with typically one axon and several dendrites reflects this asymmetry. Although neurons assume many different shapes and sizes they always maintain these two domains, which are essential for neuronal function. In the most simple view, neurons use their axon to transmit signals over long distances due to its capacity to extend to enormous lengths. Dendrites, on the other hand, are shorter and receive and integrate signals from different locations. The selection of the site where the axon and dendrites initially emerge during embryonic development is a tightly regulated event, eventually important for the correct formation of neuronal circuits, and disturbances of these processes can have pathological consequences due to circuit malformation. An important question is which mechanisms neurons utilize to specify the sites where axonal and dendrite outgrowth occurs and how their identities are maintained during and after development. The formation of these functionally diverse domains is the result of polarized differences of membrane and protein delivery, mitochondria transport, actin dynamics and microtubule stability. However how and in which temporal order all those events which coordinate the selection and maintenance of axons and dendrites is still under investigation. This selection of articles shall highlight new findings, which help to unravel all molecular and cellular events important for neuronal polarity establishment and maintenance. 2021-02-11T20:50:33Z 2021-02-11T20:50:33Z 2019-01-23 14:53:42 2018 book 31927 16648714 9782889455171 https://directory.doabooks.org/handle/20.500.12854/54518 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5122/neuronal-polarity-establishment-and-maintenance Frontiers Media SA 10.3389/978-2-88945-517-1 10.3389/978-2-88945-517-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455171 172 open access |
| spellingShingle | RC321-571 Q1-390 neuronal migration neuronal polarity dendrites neurogenesis axon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Froylan Calderon de Anda Annette Gaertner Neuronal Polarity: Establishment and Maintenance |
| title | Neuronal Polarity: Establishment and Maintenance |
| title_full | Neuronal Polarity: Establishment and Maintenance |
| title_fullStr | Neuronal Polarity: Establishment and Maintenance |
| title_full_unstemmed | Neuronal Polarity: Establishment and Maintenance |
| title_short | Neuronal Polarity: Establishment and Maintenance |
| title_sort | neuronal polarity establishment and maintenance |
| topic | RC321-571 Q1-390 neuronal migration neuronal polarity dendrites neurogenesis axon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 neuronal migration neuronal polarity dendrites neurogenesis axon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 31927 |
| work_keys_str_mv | AT froylancalderondeanda neuronalpolarityestablishmentandmaintenance AT annettegaertner neuronalpolarityestablishmentandmaintenance |