Neuroproteomics
The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how...
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| Główni autorzy: | , |
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| Format: | Online |
| Język: | angielski |
| Wydane: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | 44747 |
| Etykiety: |
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| _version_ | 1869516563579666432 |
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| author | Williams, Kenneth R. Nairn, Angus C. |
| author_browse | Nairn, Angus C. Williams, Kenneth R. |
| author_facet | Williams, Kenneth R. Nairn, Angus C. |
| author_sort | Williams, Kenneth R. |
| collection | Directory of Open Access Books |
| description | The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes. |
| format | Online |
| id | doab-20.500.12854ir-54529 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-545292024-03-30T23:21:55Z Neuroproteomics Williams, Kenneth R. Nairn, Angus C. R5-920 RC346-429 n/a analgesia quantitative phosphoproteomics neurodegeneration neuron neuronal circuits mating sex-specific differences AMPA receptor complex parallel reaction monitoring splicing phosphorylation peptidylglycine ?-amidating monooxygenase pherophorin Alzheimer’s disease neuroscience yohimbine synapses adolescence conformational antibody opioid receptors protein interaction networks Alzheimer’s Disease transmembrane AMPA receptor regulatory protein neuroproteome ethanol U1 snRNP mass spectroscopy morphine protein phosphatase-1 neuroproteomics axons reinstatement DIA voltage gated channels prohormone convertase postsynaptic density neuroimmune dendrites carboxypeptidase GPCR signaling CaMKII FGF14 SynCAM nicotinic receptor synaptic plasticity plasma serum corticosterone dopamine Receptor-type tyrosine-protein phosphatase zeta Ptprz1 PRM cell type schizophrenia laser capture microdissection synapse specificity LC-MS/MS mouse drug abuse synaptic cleft striatum Cadm cytokine spinophilin PSD trans-synaptic adhesion nicotine proximity labeling biomarkers addiction PKA synapse proteome signal peptide ventral tegmental area protein aggregation cerebrospinal fluid bioinformatics progressive ratio interactome subtilisin affinity chromatography basal ganglia cocaine targeted proteomics postsynaptic mass spectrometry connectome quantitative mass spectrometry biotinylation proteomics amphetamine autism data-independent acquisition excitatory/inhibitory tone neuropeptidomics matrix metalloproteinase cilia R-PTP-zeta cognitive impairment thema EDItEUR::M Medicine and Nursing The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes. 2021-02-11T20:51:18Z 2021-02-11T20:51:18Z 2020-04-07 23:07:08 2020 book 44747 9783039281077 9783039281060 https://directory.doabooks.org/handle/20.500.12854/54529 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2022 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-107-7 10.3390/books978-3-03928-107-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039281077 9783039281060 318 open access |
| spellingShingle | R5-920 RC346-429 n/a analgesia quantitative phosphoproteomics neurodegeneration neuron neuronal circuits mating sex-specific differences AMPA receptor complex parallel reaction monitoring splicing phosphorylation peptidylglycine ?-amidating monooxygenase pherophorin Alzheimer’s disease neuroscience yohimbine synapses adolescence conformational antibody opioid receptors protein interaction networks Alzheimer’s Disease transmembrane AMPA receptor regulatory protein neuroproteome ethanol U1 snRNP mass spectroscopy morphine protein phosphatase-1 neuroproteomics axons reinstatement DIA voltage gated channels prohormone convertase postsynaptic density neuroimmune dendrites carboxypeptidase GPCR signaling CaMKII FGF14 SynCAM nicotinic receptor synaptic plasticity plasma serum corticosterone dopamine Receptor-type tyrosine-protein phosphatase zeta Ptprz1 PRM cell type schizophrenia laser capture microdissection synapse specificity LC-MS/MS mouse drug abuse synaptic cleft striatum Cadm cytokine spinophilin PSD trans-synaptic adhesion nicotine proximity labeling biomarkers addiction PKA synapse proteome signal peptide ventral tegmental area protein aggregation cerebrospinal fluid bioinformatics progressive ratio interactome subtilisin affinity chromatography basal ganglia cocaine targeted proteomics postsynaptic mass spectrometry connectome quantitative mass spectrometry biotinylation proteomics amphetamine autism data-independent acquisition excitatory/inhibitory tone neuropeptidomics matrix metalloproteinase cilia R-PTP-zeta cognitive impairment thema EDItEUR::M Medicine and Nursing Williams, Kenneth R. Nairn, Angus C. Neuroproteomics |
| title | Neuroproteomics |
| title_full | Neuroproteomics |
| title_fullStr | Neuroproteomics |
| title_full_unstemmed | Neuroproteomics |
| title_short | Neuroproteomics |
| title_sort | neuroproteomics |
| topic | R5-920 RC346-429 n/a analgesia quantitative phosphoproteomics neurodegeneration neuron neuronal circuits mating sex-specific differences AMPA receptor complex parallel reaction monitoring splicing phosphorylation peptidylglycine ?-amidating monooxygenase pherophorin Alzheimer’s disease neuroscience yohimbine synapses adolescence conformational antibody opioid receptors protein interaction networks Alzheimer’s Disease transmembrane AMPA receptor regulatory protein neuroproteome ethanol U1 snRNP mass spectroscopy morphine protein phosphatase-1 neuroproteomics axons reinstatement DIA voltage gated channels prohormone convertase postsynaptic density neuroimmune dendrites carboxypeptidase GPCR signaling CaMKII FGF14 SynCAM nicotinic receptor synaptic plasticity plasma serum corticosterone dopamine Receptor-type tyrosine-protein phosphatase zeta Ptprz1 PRM cell type schizophrenia laser capture microdissection synapse specificity LC-MS/MS mouse drug abuse synaptic cleft striatum Cadm cytokine spinophilin PSD trans-synaptic adhesion nicotine proximity labeling biomarkers addiction PKA synapse proteome signal peptide ventral tegmental area protein aggregation cerebrospinal fluid bioinformatics progressive ratio interactome subtilisin affinity chromatography basal ganglia cocaine targeted proteomics postsynaptic mass spectrometry connectome quantitative mass spectrometry biotinylation proteomics amphetamine autism data-independent acquisition excitatory/inhibitory tone neuropeptidomics matrix metalloproteinase cilia R-PTP-zeta cognitive impairment thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC346-429 n/a analgesia quantitative phosphoproteomics neurodegeneration neuron neuronal circuits mating sex-specific differences AMPA receptor complex parallel reaction monitoring splicing phosphorylation peptidylglycine ?-amidating monooxygenase pherophorin Alzheimer’s disease neuroscience yohimbine synapses adolescence conformational antibody opioid receptors protein interaction networks Alzheimer’s Disease transmembrane AMPA receptor regulatory protein neuroproteome ethanol U1 snRNP mass spectroscopy morphine protein phosphatase-1 neuroproteomics axons reinstatement DIA voltage gated channels prohormone convertase postsynaptic density neuroimmune dendrites carboxypeptidase GPCR signaling CaMKII FGF14 SynCAM nicotinic receptor synaptic plasticity plasma serum corticosterone dopamine Receptor-type tyrosine-protein phosphatase zeta Ptprz1 PRM cell type schizophrenia laser capture microdissection synapse specificity LC-MS/MS mouse drug abuse synaptic cleft striatum Cadm cytokine spinophilin PSD trans-synaptic adhesion nicotine proximity labeling biomarkers addiction PKA synapse proteome signal peptide ventral tegmental area protein aggregation cerebrospinal fluid bioinformatics progressive ratio interactome subtilisin affinity chromatography basal ganglia cocaine targeted proteomics postsynaptic mass spectrometry connectome quantitative mass spectrometry biotinylation proteomics amphetamine autism data-independent acquisition excitatory/inhibitory tone neuropeptidomics matrix metalloproteinase cilia R-PTP-zeta cognitive impairment thema EDItEUR::M Medicine and Nursing |
| url | 44747 |
| work_keys_str_mv | AT williamskennethr neuroproteomics AT nairnangusc neuroproteomics |