Never-resting microglia: physiological roles in the healthy brain and pathological implications
Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveri...
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| Formato: | Online |
| Idioma: | inglês |
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Frontiers Media SA
2021
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| Acesso em linha: | 17698 |
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| author | Amanda Sierra Marie-Eve Tremblay Hiroaki Wake |
| author_browse | Amanda Sierra Hiroaki Wake Marie-Eve Tremblay |
| author_facet | Amanda Sierra Marie-Eve Tremblay Hiroaki Wake |
| author_sort | Amanda Sierra |
| collection | Directory of Open Access Books |
| description | Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the regulation of adult neurogenesis as well as hippocampal learning and memory; among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic also summarized the current view of microglial nomenclature, phenotypes, origin and differentiation, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state have been discussed. In conclusion, this Research Topic sought to emphasize how the current research in neuroscience is challenged by never-resting microglia. |
| format | Online |
| id | doab-20.500.12854ir-54545 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-545452024-04-05T12:36:19Z Never-resting microglia: physiological roles in the healthy brain and pathological implications Amanda Sierra Marie-Eve Tremblay Hiroaki Wake RC321-571 Q1-390 phenotype Neuroprotection Disease Health Neurogenesis Phagocytosis Synapses Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the regulation of adult neurogenesis as well as hippocampal learning and memory; among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic also summarized the current view of microglial nomenclature, phenotypes, origin and differentiation, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state have been discussed. In conclusion, this Research Topic sought to emphasize how the current research in neuroscience is challenged by never-resting microglia. 2021-02-11T20:53:07Z 2021-02-11T20:53:07Z 2015-11-19 16:29:12 2015 book 17698 16648714 9782889193691 https://directory.doabooks.org/handle/20.500.12854/54545 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Never-resting_microglia_physiological_roles_in_the_healthy_brain_and_pathological_implications/431 http://journal.frontiersin.org/researchtopic/868/never-resting-microglia-physiological-roles-in-the-healthy-brain-and-pathological-implications Frontiers Media SA 10.3389/978-2-88919-369-1 10.3389/978-2-88919-369-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193691 172 open access |
| spellingShingle | RC321-571 Q1-390 phenotype Neuroprotection Disease Health Neurogenesis Phagocytosis Synapses Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Amanda Sierra Marie-Eve Tremblay Hiroaki Wake Never-resting microglia: physiological roles in the healthy brain and pathological implications |
| title | Never-resting microglia: physiological roles in the healthy brain and pathological implications |
| title_full | Never-resting microglia: physiological roles in the healthy brain and pathological implications |
| title_fullStr | Never-resting microglia: physiological roles in the healthy brain and pathological implications |
| title_full_unstemmed | Never-resting microglia: physiological roles in the healthy brain and pathological implications |
| title_short | Never-resting microglia: physiological roles in the healthy brain and pathological implications |
| title_sort | never resting microglia physiological roles in the healthy brain and pathological implications |
| topic | RC321-571 Q1-390 phenotype Neuroprotection Disease Health Neurogenesis Phagocytosis Synapses Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 phenotype Neuroprotection Disease Health Neurogenesis Phagocytosis Synapses Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17698 |
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