Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors
Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled...
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| פורמט: | Online |
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Frontiers Media SA
2021
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| נושאים: | |
| גישה מקוונת: | 18867 |
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| _version_ | 1869525132717850624 |
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| author | Atsuhiko Ichimura Ikuo Kimura |
| author_browse | Atsuhiko Ichimura Ikuo Kimura |
| author_facet | Atsuhiko Ichimura Ikuo Kimura |
| author_sort | Atsuhiko Ichimura |
| collection | Directory of Open Access Books |
| description | Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled receptors (GPCRs) that act as FFA receptors (FFARs) have been identified; GPR40/FFAR1, GPR119, and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain FFAs. GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain FFAs. These FFARs have come to be regarded as new drug targets for metabolic disorder such as obesity and type 2 diabetes, because a number of pharmacological and physiological studies have shown that these receptors are primarily involved in the energy metabolism in various tissues; insulin secretion, gastrointestinal hormone secretion, adipokine secretion, regulation of inflammation, regulation of autonomic nervous system, relation to gut microbiota, and so on. This Research Topic provides a comprehensive overview of the energy regulation by free fatty acid receptors and a new prospect for treatment of metabolic disorder such as obesity and type 2 diabetes. |
| format | Online |
| id | doab-20.500.12854ir-55086 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-550862022-01-31T11:18:59Z Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors Atsuhiko Ichimura Ikuo Kimura RC648-665 R5-920 microbiota Obesity GPCRs Insulin Resistance FFARs SCFAs free fatty acids Metabolism diabetes energy homeostasis Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled receptors (GPCRs) that act as FFA receptors (FFARs) have been identified; GPR40/FFAR1, GPR119, and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain FFAs. GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain FFAs. These FFARs have come to be regarded as new drug targets for metabolic disorder such as obesity and type 2 diabetes, because a number of pharmacological and physiological studies have shown that these receptors are primarily involved in the energy metabolism in various tissues; insulin secretion, gastrointestinal hormone secretion, adipokine secretion, regulation of inflammation, regulation of autonomic nervous system, relation to gut microbiota, and so on. This Research Topic provides a comprehensive overview of the energy regulation by free fatty acid receptors and a new prospect for treatment of metabolic disorder such as obesity and type 2 diabetes. 2021-02-11T21:30:49Z 2021-02-11T21:30:49Z 2016-04-07 11:22:02 2016 book 18867 16648714 9782889197477 https://directory.doabooks.org/handle/20.500.12854/55086 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Obesity_and_Diabetes_Energy_Regulation_by_Free_Fatty_Acid_Receptors/793#nogo http://journal.frontiersin.org/researchtopic/2439/obesity-and-diabetes-energy-regulation-by-free-fatty-acid-receptors Frontiers Media SA 10.3389/978-2-88919-747-7 10.3389/978-2-88919-747-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197477 45 open access |
| spellingShingle | RC648-665 R5-920 microbiota Obesity GPCRs Insulin Resistance FFARs SCFAs free fatty acids Metabolism diabetes energy homeostasis Atsuhiko Ichimura Ikuo Kimura Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
| title | Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
| title_full | Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
| title_fullStr | Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
| title_full_unstemmed | Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
| title_short | Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
| title_sort | obesity and diabetes energy regulation by free fatty acid receptors |
| topic | RC648-665 R5-920 microbiota Obesity GPCRs Insulin Resistance FFARs SCFAs free fatty acids Metabolism diabetes energy homeostasis |
| topic_facet | RC648-665 R5-920 microbiota Obesity GPCRs Insulin Resistance FFARs SCFAs free fatty acids Metabolism diabetes energy homeostasis |
| url | 18867 |
| work_keys_str_mv | AT atsuhikoichimura obesityanddiabetesenergyregulationbyfreefattyacidreceptors AT ikuokimura obesityanddiabetesenergyregulationbyfreefattyacidreceptors |