Obesity-induced inflammation and insulin resistance
Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying...
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
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Frontiers Media SA
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 18183 |
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| _version_ | 1869523177857613824 |
|---|---|
| author | Tsuguhito Ota |
| author_browse | Tsuguhito Ota |
| author_facet | Tsuguhito Ota |
| author_sort | Tsuguhito Ota |
| collection | Directory of Open Access Books |
| description | Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the innate immune system with subsequent recruitment of immune cells such as macrophages and T cells, which contributes to the development of insulin resistance. In particular, a significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). ATMs are a prominent source of proinflammatory cytokines, such as TNF-a and IL-6, that can block insulin action in adipose tissue, skeletal muscle, and liver autocrine/paracrine signaling and cause systemic insulin resistance via endocrine signaling, providing a potential link between inflammation and insulin resistance. All articles in this topic highlight the interconnection between obesity, inflammation, and insulin resistance in all its diversity to the mechanisms of obesity-induced inflammation and role of immune system in the pathogenesis of insulin resistance and diabetes. |
| format | Online |
| id | doab-20.500.12854ir-55087 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-550872022-01-31T11:52:18Z Obesity-induced inflammation and insulin resistance Tsuguhito Ota RC648-665 R5-920 pattern-recognition receptor innate immunity inflammation Bariatric surgery macrophage Adipose Tissue insulin resistance obesity Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the innate immune system with subsequent recruitment of immune cells such as macrophages and T cells, which contributes to the development of insulin resistance. In particular, a significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). ATMs are a prominent source of proinflammatory cytokines, such as TNF-a and IL-6, that can block insulin action in adipose tissue, skeletal muscle, and liver autocrine/paracrine signaling and cause systemic insulin resistance via endocrine signaling, providing a potential link between inflammation and insulin resistance. All articles in this topic highlight the interconnection between obesity, inflammation, and insulin resistance in all its diversity to the mechanisms of obesity-induced inflammation and role of immune system in the pathogenesis of insulin resistance and diabetes. 2021-02-11T21:30:52Z 2021-02-11T21:30:52Z 2016-01-19 14:05:46 2014 book 18183 16648714 9782889194285 https://directory.doabooks.org/handle/20.500.12854/55087 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Obesity-induced_inflammation_and_insulin_resistance/484#nogo http://journal.frontiersin.org/researchtopic/880/obesity-induced-inflammation-and-insulin-resistance Frontiers Media SA 10.3389/978-2-88919-428-5 10.3389/978-2-88919-428-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194285 120 open access |
| spellingShingle | RC648-665 R5-920 pattern-recognition receptor innate immunity inflammation Bariatric surgery macrophage Adipose Tissue insulin resistance obesity Tsuguhito Ota Obesity-induced inflammation and insulin resistance |
| title | Obesity-induced inflammation and insulin resistance |
| title_full | Obesity-induced inflammation and insulin resistance |
| title_fullStr | Obesity-induced inflammation and insulin resistance |
| title_full_unstemmed | Obesity-induced inflammation and insulin resistance |
| title_short | Obesity-induced inflammation and insulin resistance |
| title_sort | obesity induced inflammation and insulin resistance |
| topic | RC648-665 R5-920 pattern-recognition receptor innate immunity inflammation Bariatric surgery macrophage Adipose Tissue insulin resistance obesity |
| topic_facet | RC648-665 R5-920 pattern-recognition receptor innate immunity inflammation Bariatric surgery macrophage Adipose Tissue insulin resistance obesity |
| url | 18183 |
| work_keys_str_mv | AT tsuguhitoota obesityinducedinflammationandinsulinresistance |