Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders
Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegene...
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| Format: | Online |
| Jezik: | angleščina |
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Frontiers Media SA
2021
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| Online dostop: | 31973 |
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Brez oznak, prvi označite!
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| _version_ | 1869528456033730560 |
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| author | Aasef G. Shaikh Alessandra Rufa |
| author_browse | Aasef G. Shaikh Alessandra Rufa |
| author_facet | Aasef G. Shaikh Alessandra Rufa |
| author_sort | Aasef G. Shaikh |
| collection | Directory of Open Access Books |
| description | Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles.</p><p>The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. </p><p>The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: </p><p>1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. </p><p>2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks. |
| format | Online |
| id | doab-20.500.12854ir-55137 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-551372024-03-31T13:09:59Z Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders Aasef G. Shaikh Alessandra Rufa R5-920 RC346-429 genetic tremor immune basal ganglia ataxia nystagmus parkinson degenerative cerebellum thema EDItEUR::M Medicine and Nursing Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles.</p><p>The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. </p><p>The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: </p><p>1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. </p><p>2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks. 2021-02-11T21:34:23Z 2021-02-11T21:34:23Z 2019-01-23 14:53:43 2018 book 31973 16648714 9782889455638 https://directory.doabooks.org/handle/20.500.12854/55137 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5057/ocular-motor-and-vestibular-deficits-in-neurometabolic-neurogenetic-and-neurodegenerative-diseases Frontiers Media SA 10.3389/978-2-88945-563-8 10.3389/978-2-88945-563-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455638 247 open access |
| spellingShingle | R5-920 RC346-429 genetic tremor immune basal ganglia ataxia nystagmus parkinson degenerative cerebellum thema EDItEUR::M Medicine and Nursing Aasef G. Shaikh Alessandra Rufa Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders |
| title | Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders |
| title_full | Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders |
| title_fullStr | Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders |
| title_full_unstemmed | Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders |
| title_short | Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders |
| title_sort | ocular motor and vestibular function in neurometabolic neurogenetic and neurodegenerative disorders |
| topic | R5-920 RC346-429 genetic tremor immune basal ganglia ataxia nystagmus parkinson degenerative cerebellum thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC346-429 genetic tremor immune basal ganglia ataxia nystagmus parkinson degenerative cerebellum thema EDItEUR::M Medicine and Nursing |
| url | 31973 |
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